key: cord-0777672-vgxa7w6a
authors: Madukwe, Jerry
title: Apart, Together: Reflections on the COVID-19 Pandemic
date: 2021-10-20
journal: Trends Pharmacol Sci
DOI: 10.1016/j.tips.2021.10.007
sha: 05de66b711abdb72f4cf218f3cdb4e079cb90dfe
doc_id: 777672
cord_uid: vgxa7w6a

nan

December 2021 marks two years since the first reports of an outbreak were covered by a handful of international media outlets. Few could have envisioned what would transpire over the coming months. None can accurately predict how things will unfold in the years to come. The pandemic continues, diminished in some places, unabated in others, and periodically re-emerging throughout. Though the future remains uncertain, we have chosen to use this anniversary as an opportunity to reflect on the indelible aspects of this uniquely difficult epoch and our hopes for the future.

After learning of the passing of community members, including authors and reviewers with whom we have collaborated on articles for Trends, we were moved to create this reflection, in part, to remember all those whose scientific achievements endure beyond their time with us. The Trends team also recognizes the scientists, researchers, clinicians, and healthcare workers who lost their lives to COVID-19, whether directly or indirectly. These include individuals who succumbed to complications arising from SARS-CoV2 infections, including those whose deaths reflect the growing mental health toll of the pandemic. Still others suffered delayed diagnosis and treatment for chronic illnesses and diseases because of overburdened, nearly broken healthcare systems. These are sobering reminders of the sacrifices that have been made by so many, and the magnitude of the loss endured by our community, and countless others.

As the COVID-19 outbreak rapidly evolved into a global pandemic, phrases based on scientific principles such as flatten the curve, herd immunity, 6-feet apart, and hotspots assumed unprecedented importance in everyday life. The phrase follow the science soon transformed into a trending tagline, with the status of scientists seemingly elevated to that of celebrities. Some medics and frontline workers were even featured on covers of fashion magazines i , an unusual recognition of their vital contributions to the community at large, and rightfully so. Yet, despite the esteem and accomplishments, scientists and clinicians are human and vulnerable to the deadly virus they have led the fight against.

Of all the phrases that have become a part of our collective vocabulary during the pandemic, one became a global rallying cry as we faced a common threat that forced us to distance ourselves from each other: All in this together. The scientific community has embraced this call for collective action, sustaining an unparalleled pace of progress and discovery in the last two years, even in the face of significant setbacks. With lockdowns in place worldwide, laboratory closures and restrictions imperilled research on a global scale. In some institutions, scientists and clinicians were required or encouraged to stop their personal research to help fight Covid-19 instead by processing tests, formulating sanitizers, donating equipment, and/or working on the frontlines [1] ii-iv . Laboratory heads scrambled to sustain their research and keep their teams safe, with some even struggling to obtain basic supplies and keep model organisms alive. In academia, colleges and universities faced J o u r n a l P r e -p r o o f existential threats, as they grappled with plummeting student enrolment and the challenges of remote learning. Under these circumstances, some researchers have lost their jobs. Those who remain face an exceptionally fraught path for navigating even standard career milestones like preparing grants and tenure packages. Increasingly, there is strong evidence that this path is more fraught for women researchers, researchers with children, and early-career researchers [1-5] v-vii . Undeniably, the pandemic has also taken a significant toll on the mental well-being of of us all; individuals have coped and dealt with the severe restrictions and isolation to varying levels of success that frankly depends on the day, month, and season. The wounds inflicted by the pandemic on the scientific community run deep and will certainly take time to heal.

Science continues, despite everything, because of the compassion, sacrifice, and endurance of our communities. Those with access to their laboratories worked grueling hours to advance coronavirus research, while those barred from their space embraced creative approaches to continue their own, still vital, research. Group meetings and departmental visits through virtual platforms ensured that past connections were maintained, while still providing a path forward for forging new ones. Conferences organized by various sections of the scientific community turned virtual, providing access to many who would not have otherwise been able to attend. Institutions and grant agencies stepped in to provide tenure extensions and funding resources to ease the crises. Scientific editors managed unprecedented volumes of manuscripts, accelerating scientific publishing to meet the acute demands of the communities, while maintaining scientific integrity. In addition, relevant COVID-19 research and other materials have also been made freely available to the public ix . As Trends editors, we have worked closely with our communities to address aspects of the pandemic, from how it impacts science and scientists to synthesizing reviews that summarize the explosion of data in an accessible manner x . The pandemic has captured the public's attention and interest, and in response, scientists have used social media to discuss COVID-19 with the public directly. These discussions cover all aspects of the COVID-19 pandemic, such as conspiracies on the origin of the virus, effects and myths of vaccination, basic immunological concepts with easy-to-follow animations, and the science behind the effectiveness of wearing a mask, just to name a few [6, 7] viii . It is our hope that the community continues these successful public outreach efforts, even after we emerge from this pandemic, and that the communication and support of each other experienced during these trying times remain.

Together, these efforts have led, and continue to lead, to astounding achievements. From sequencing the SARS-CoV-2 genome and sharing it with the world, to unearthing host factors involved in viral entry, characterizing methods of transmission and spread of the virus, and continued genomic surveillance of new viral variants, the scientific community is working tirelessly and collaboratively to develop and deploy tools to combat the pandemic. Nations with the means to do so are investing an incredible amount of funding into COVID-19 research, helping streamline clinical trials and expedite approvals for life-saving therapies and vaccines. The collective effort, unity, and collaboration on a global scale renders it possible to move therapies from bench to bedside and is the ultimate reminder that we are all in this together. As the pandemic continues to run its uncertain course, we will prevail by remembering what we have all experienced, witnessed, and endured over these last two years, whether together or apart.

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iii) UKAEA's helping hand for the NHS -GOV.UK (www.gov.uk) https://www.gov.uk/government/news/ukaeas-helping-hand-for-the-nhs iv) How we'll get back to the lab during COVID-19 (acs.org) https://cen.acs.org/safety/labsafety/Getting-back-lab-during-COVID-19/98/i19 v) Pandemic 'threatens research as early career scientists look to leave' | Border x) Trends Collection -Apart, Together: The Pandemic -www.cell.com/trends/collections/aparttogether-pandemic