key: cord-0777109-jfraln5h
authors: Nie, Shao-Fang; Yu, Miao; Xie, Tian; Yang, Fen; Wang, Hong-Bo; Wang, Zhao-Hui; Li, Ming; Gao, Xing-Li; Lv, Bing-Jie; Wang, Shi-Jia; Zhang, Xiao-Bo; He, Shao-Lin; Qiu, Zhi-Hua; Liao, Yu-Hua; Zhou, Zi-Hua; Cheng, Xiang
title: Cardiac Troponin I Is an Independent Predictor for Mortality in Hospitalized Patients With COVID-19
date: 2020-06-15
journal: Circulation
DOI: 10.1161/circulationaha.120.048789
sha: 7ba34306091c4bfc2e15bfc21134779a0e863fad
doc_id: 777109
cord_uid: jfraln5h

nan

thyroid disease. The most common symptoms on admission were fever (77.5%), cough (32.5%), and dyspnea (24.4%). With regard to disease severity on admission, there were 101 patients (32.5%) with moderate-type, 180 (57.9%) with severe-type, and 30 (9.6%) with critical-type COVID-19. One hundred eleven patients died during hospitalization and 200 were discharged. The median time from illness onset to death was 23 days (IQR, 15-32 days). In laboratory findings, the lymphocyte count (0.5×10 9 /L [IQR, 0.4-0.8×10 9 /L] versus 1.2×10 9 /L [IQR, 0.9-1.7×10 9 /L]) was lower in the nonsurvivor group than in the discharged group. (Table) .

Although respiratory symptoms are the primary clinical manifestations of COVID-19, a portion of patients will experience severe cardiovascular injury. 2, 5 cTnI is the most important biomarker of cardiac injury. Our results indicate that the serum cTnI concentration was significantly higher in nonsurviving patients with severe acute respiratory syndrome coronavirus 2 infection than in discharged patients, and the further multivariable logistic regression identified increased cTnI concentration as an independent predictor of mortality in patients with COVID-19.

This study is limited by selection bias based on cTnI measurement. The determination of whether cTnI would be measured in each case was an individual decision by the clinician. The results do not totally represent the epidemiological data of COVID-19.

The data that support the findings of this study are available from the corresponding author upon reasonable request by email.

Xiang Cheng, MD, PhD, or Zi-Hua Zhou, MD, PhD, Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, China. Email nathancx@hotmail.com or zzhua2001@163.com

Clinical characteristics of coronavirus disease 2019 in China

Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China

Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan

None.