key: cord-0776946-5xmi7tul
authors: Melo, Thayanara Silva; Beltrão, Renata Cristina; de Mendonça, Andréia de Fátima Trindade; Duarte, Ângela Luzia Branco Pinto; Gueiros, Luiz Alcino
title: Sicca symptoms in post‐acute COVID‐19 syndrome
date: 2022-02-23
journal: Oral Dis
DOI: 10.1111/odi.14159
sha: 21d72f3b262ec640f3c5b54688b7f4837aaa25ab
doc_id: 776946
cord_uid: 5xmi7tul

nan

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first identified in December 2019 and has caused a worldwide pandemic (Zhu et al., 2020) . In addition to the unprecedented global scale morbidity and mortality associated with the acute phase, several conditions have been described in the post-infectious phasethe post-acute COVID-19 syndrome (Nalbandian et al., 2021) . This condition may share similarities to other post-acute viral syndromes described in survivors of other virulent coronavirus epidemics and seems to include symptoms such as dyspnea, chest pain, cognitive disturbances, arthralgia, and decline in quality of life (Carfi et al., 2020; Huang et al., 2021; Tenforde et al., 2020) .

The post-acute COVID-19 syndrome can be classified as subacute or ongoing symptomatic COVID-19, including symptoms 4-12 weeks beyond acute COVID-19. On the other hand, chronic or post-COVID-19 syndrome conditions are observed after 12 weeks of acute onset and are not attributable to alternative diagnoses (Nalbandian et al., 2021) . Symptoms may follow noncritical COVID-19 and affect more than 70% of individuals. Fatigue and sleep difficulties are the most commonly observed conditions (Huang et al., 2021 ). Yet, a better characterization of this syndrome is still lacking.

In this context, oral features of the post-COVID-19 syndrome are yet not described. The rehabilitation unit for survivors of severe COVID-19, located in a tertiary University Hospital in Northeast Brazil, has currently analyzed 22 individuals. The unit admits adult patients who have recovered from critical (PCR-confirmed) COVID-19 and stayed at least three days in the ICU, promoting multi-professional care, including specialists in oral medicine, speech therapy, physical therapy, nutrition, intensive care, pneumology, and infectious diseases. We have observed an intriguing manifestation of this syndrome: sicca symptoms lasting more than six months.

We have evaluated 22 patients,12/22 males with a mean age of 56.4 years old and an average length of stay in the ICU of eight days, and 9/22 required mechanical ventilation. Arterial hypertension (85%) and type II diabetes (6%) were the most commonly observed comorbidities.

The oral medicine specialist consultation was performed after admission to the unit. The mean time since hospital discharge was 155 days (sd = 21 days, ranging from 62-210 days). Schirmer I test Interestingly, a post-COVID-19 syndrome in patients with primary Sjögren's syndrome has a frequency of nearly 60% and is associated with hospitalization, baseline CRP levels, and hydroxychloroquine levels, but worsens sicca symptoms were not reported (Brito-Zerón et al., 2021) . Also, the impact of these features on oral health should be a matter of concern for future prospective cohort studies.

The long-term consequences of COVID-19 are not yet fully understood, and information in the literature is still limited. Our study shows significant changes that should be investigated in this patient profile, highlighting the importance of monitoring these patients after COVID-19.

None to declare. 

The peer review history for this article is available at https://publo ns.com/publo n/10.1111/odi.14159. 

Oral manifestations in patients with COVID-19: A living systematic review

Post-COVID-19 syndrome in patients with primary Sjögren's syndrome after acute SARS-CoV-2 infection

Gemelli against COVID-19 Post-Acute Care Study Group. Persistent symptoms in patients after acute COVID-19

Ocular findings among patients surviving COVID-19

6-month consequences of COVID-19 in patients discharged from hospital: A cohort study

Brazilian oral medicine and oral pathology: We are here during the COVID-19 pandemic

Post-acute COVID-19 syndrome

Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network-United States

From SARS and MERS to COVID-19: a brief summary and comparison of severe acute respiratory infections caused by three highly pathogenic human coronaviruses