key: cord-0775517-5z203dgk
authors: Yoshida, Masayuki
title: More Than Clean, Sustainable, and Renewable Energy Source: New Therapeutic Role for Hydrogen?
date: 2022-02-28
journal: JACC Basic Transl Sci
DOI: 10.1016/j.jacbts.2021.12.008
sha: ca4244add370727f92235c4fc1cadc99cb61de14
doc_id: 775517
cord_uid: 5z203dgk

[Figure: see text]

Hydrogen has been shown to scavenge the hydroxyl radical (OH) and acts as an antioxidant agent to exert various pathological conditions, including brain ischemia/reperfusion injury, experimental liver injury, and diabetes. Moreover, hydrogen was shown to have beneficial effects on cancer. Although hydroxyl radical scavenging activity has been regarded as the primal action of hydrogen, there are several other potential mechanisms in which hydrogen may play roles, eg, certain enzymes may become activated when they interact with hydrogen, or hydrogen gas may suppress auto-oxidation of lipid mediators and modify downstream signaling. 2 The authors have shown for the first time that hydrogen may suppress NET formation via reduced Ca 2þ -dependent PADI 4 activation through reduction of hypochlorous acid production. 

H2 inhibits the formation of neutrophil extracellular traps

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

High-fat diet enhances neutrophil adhesion in LDLR-null mice via hypercitrullination of histone H3