key: cord-0775445-812b4bus
authors: Lai, Jonathan; Romero, Roberto; Tarca, Adi L.; Iliodromiti, Stamatina; Rehal, Anoop; Banerjee, Anita; Yu, Christina; Peeva, Gergana; Palaniappan, Vadivu; Tan, Linda; Mehta, Mahishee; Nicolaides, Kypros H.
title: SARS-COV-2 and the subsequent development of preeclampsia and preterm birth: evidence of a dose response relationship supporting causality
date: 2021-08-26
journal: Am J Obstet Gynecol
DOI: 10.1016/j.ajog.2021.08.020
sha: ebf6c6ea5d63c1cc47f5f53bac70987627687eba
doc_id: 775445
cord_uid: 812b4bus

nan

Reprints will not be available. The prior risk of preeclampsia in a cohort of patients with comparable risk factors as those 140 of the study population was about 1% (Figure 1A) . The observed rate of preeclampsia, 141 after excluding cases diagnosed before SARS-CoV-2 infection, was higher than 142 expected: 1.9% in asymptomatic patients, 2.2% in patients with mild COVID-19, 5.7% 143 with moderate and 11.1% among patients with severe disease (Figure 1A) . This 144 monotonic relationship between the severity of COVID-19 and the risk of developing 145 preeclampsia was statistically significant (chi-square test for trend; p=0.0017). We then 146 compared the risk of preeclampsia between asymptomatic patients (reference group) and 147 those with COVID-19 symptoms while adjusting for differences in the prior risk of 

Pre-eclampsia-like syndrome induced by 210 severe COVID-19: a prospective observational study

Disease Severity and Perinatal Outcomes 212 of Pregnant Patients With Coronavirus Disease 2019 (COVID-19)

SARS-COV-2 infection during pregnancy and risk 215 of preeclampsia: a systematic review and meta-analysis

Competing risks 218 model in screening for preeclampsia by maternal characteristics and medical 219 history

Preeclampsia and COVID-19: 221 results from the INTERCOVID prospective longitudinal study

The 224 association between SARS-CoV-2 infection and preterm delivery: a prospective 225 study with a multivariable analysis