key: cord-0772822-z9qd3x8c authors: Martins-Filho, Paulo Ricardo; Antunes de Souza Araújo, Adriano; Pereira, Luciana Xavier; Quintans-Júnior, Lucindo José; de Souza Barboza, Waneska; Cavalcante, Taise Ferreira; Feitosa de Souza, Mércia; de Oliveira Góes, Marco Aurélio; Santos, Victor Santana title: Factors Associated with Mortality among Hospitalized Patients with COVID-19: A Retrospective Cohort Study date: 2020-11-17 journal: Am J Trop Med Hyg DOI: 10.4269/ajtmh.20-1170 sha: 9f9f2772370f058b09e0f0888bd8cddd1f95dc8f doc_id: 772822 cord_uid: z9qd3x8c Information on the risk factors for COVID-19 mortality in low- and middle-income countries is still scarce. In this retrospective cohort study, we analyzed the factors associated with COVID-19 mortality in hospitalized patients in a poor area of Brazil. Logistic regression was used to identify factors independently associated with mortality, including gender, age, and the presence of underlying medical conditions. A total of 1,207 patients were included in the analysis, and a 1.5-fold increase in COVID-19 mortality was found among patients aged > 65 years with hypertension and diabetes (odds ratio [OR]: 1.50, 95% CI: 1.02–2.19). Moreover, infectious disease (OR: 4.31, 95% CI: 1.39–13.39), kidney disease (OR: 2.59, 95% CI: 1.27–5.27), and heart disease (OR: 2.00, 95% CI: 1.31–3.04) were also predictive for COVID-19 in-hospital death. This large cohort provides important data on potential factors associated with COVID-19 mortality in Brazil. SARS-CoV-2 is an emerging RNA virus associated with a severe acute respiratory disease known as COVID-19. Globally, SARS-CoV-2 infected more than 50 million people and caused more than 1.2 million deaths until November 9, 2020. In high-income countries, COVID-19 mortality has been higher in men, older people, and those with some comorbidity, including hypertension, diabetes, and cardiovascular disease. 1 However, information on the risk factors in low-and middleincome countries is still scarce. Herein, we report the factors associated with COVID-19 mortality in hospitalized patients in a poor area of Brazil. This retrospective cohort study enrolled all adults with PCRconfirmed COVID-19 who were consecutively admitted to public and private hospitals in Aracaju, Sergipe state, Northeast Brazil, from March 17 to July 14, 2020. Aracaju is a coastal city located in the poorest region in a country marked by large regional disparities. This city has an estimated population of 657,053 inhabitants and a high proportion of low-income households (42.9%). Recently, it was found that neighborhoods with poor living conditions in Aracaju are more likely to have higher COVID-19 fatality rates. 2 Data on COVID-19 cases and deaths were extracted from the microdata catalog and official bulletin of the Municipal Secretariat of Health. We excluded patients with incomplete information, pregnant women, patients aged 18 years and younger, and those treated in hospital outside of Aracaju. Data collected included the outcome of interest (death) and potential factors associated with COVID-19 mortality: gender, age, and the presence of underlying medical conditions (gastrointestinal disease, chronic pulmonary disease, asthma, neurodegenerative disease, stroke, hypothyroidism, cancer, non-HIV immunosuppressive disease, obesity, infectious disease, kidney disease, heart disease, hypertension, and diabetes). Data were presented as absolute and relative frequencies, and comparisons between survivors and non-survivors were expressed as odds ratio (OR) with 95% CIs. Logistic regression was used to identify factors independently associated with mortality. First, a univariate model was performed. Afterward, interaction was checked to control the relationship between covariates and their effect on the outcome. Finally, we included in multivariate analyses with backward selection all factors that have shown a relaxed P-value £ 0.30. Two multivariate models were developed. Model 1 included a standard logistic regression, and model 2 incorporated interaction for age, hypertension, and diabetes. P-values < 0.05 were considered statistically significant. All data were deidentified, and analyzes were performed using JASP software version 0.13 (JASP Team, Amsterdam, Netherlands). A total of 1,207 of 1,632 patients initially considered met the eligibility criteria and were included in the analysis. The median (IIQ) age was 60 (46-73) years. Seven hundred twenty-four (60.0%) were men, and 708 (58.7%) patients had at least one coexisting condition (Table 1) COVID-19 mortality has been high among critically ill patients and varies widely according to country; population characteristics including biological, environmental, and socioeconomic factors; social isolation policies; and healthsystem capacity. As other reports, older age and people with kidney and heart diseases were at a higher risk of death. 1, 3, 4 In addition, this cohort identified some novel patient-level factors associated with COVID-19 mortality, including infectious diseases coinfection and the interaction between older age and combined hypertension and diabetes. In Brazil, one in five Brazilian adults has two or more comorbidities 5 which may increase the susceptibility to COVID-19 mortality. The pivotal link between SARS-CoV-2 and downregulation of angiotensin-converting enzyme-2 in people with multiple comorbidities especially diabetes and hypertension may be a critical role in the overproduction of pro-inflammatory cytokines and COVID-19 severity. 6 In addition to the relationship between older age and comorbidities, people in poor communities are less likely to have access to health care and social protection, and live in crowded homes with inadequate sanitation and hygiene, which increase the risk for COVID-19 transmission and death. 2 Although only 1.0% of patients were coinfected with some infectious disease and COVID-19, there was an increased risk of death. Some infectious diseases can cause increased levels of inflammatory cytokines. 7 The dysregulated immune response in individuals with severe COVID-19 seems to be associated with a cytokine storm. However, the interaction between COVID-19 and other infectious diseases is highly complex, and further epidemiological and immunological studies should be performed. Although we could not assess effects of other important variables, such as laboratory findings, respiratory support, chronic medications, and acute organ injuries during hospitalization, this large cohort provides data on potential factors associated with COVID-19 mortality from a poor area in Brazil. As risk factors may vary across populational groups, further studies in low-and middle-income cities should be performed to better understand what factors are associated with COVID-19 mortality. Factors associated with mortality in patients with COVID-19. A quantitative evidence synthesis of clinical and laboratory data COVID-19 fatality rates related to social inequality in Northeast Brazil: a neighborhood-level analysis Risk factors associated with mortality among patients with COVID-19 in intensive care units in Lombardy, Italy Factors associated with death in critically ill patients with coronavirus disease 2019 in the US Contextual and individual inequalities of multimorbidity in Brazilian adults: a cross-sectional national-based study The pivotal link between ACE2 deficiency and SARS-CoV-2 infection Clinical characteristics and outcomes in patients with COVID-2019 and leprosy FACTORS ASSOCIATED WITH COVID-19 MORTALITY This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.