key: cord-0772133-rzo2ypgv
authors: Ricco, M.; Valente, M.; Marchesi, F.
title: Are symptoms associated with SARS-CoV-2 infections evolving over time?
date: 2022-02-02
journal: Infect Dis Now
DOI: 10.1016/j.idnow.2022.01.006
sha: 69bd17daff60d79d1b01c8c87961025582653dac
doc_id: 772133
cord_uid: rzo2ypgv

nan

J o u r n a l P r e -p r o o f queries [1] . The search can also be focused on a specific geographical area and a specific timeframe, allowing for more accurate comparisons with conventional indicators [1] [2] [3] . For instance, a recent preprint based on a RSV analysis performed on UK data for the month of December 2021 [4] suggested that the recently emerged SARS-CoV-2 variant of concern (VOC) B.1.1.529 (i.e. "Omicron") may have elicited a marked increase in Google searches for symptoms such as conjunctivitis, chills, cough, aches, and fever compared to December 2020. Not coincidentally, there is evidence showing that Omicron may be associated with an increased prevalence of symptoms such as sore throat, fever, and cough with a marked reduction in reporting of loss of smell and taste in PCR-positive individuals [5] .

Following the progressive spread of Omicron to other European countries, including Italy, we performed a GT-based RSV using a series of keywords (Table 1 ) derived from the aforementioned reports, plus the keyword "insomnia" [4] [5] [6] .

To better cope with the background RSVs for symptoms that may be associated with common respiratory disorders, we used country option set to "Italy" ─ the first European country to be heavily impacted by the SARS-CoV-2 pandemic ─ while we opted for a broader search period (January 1, 2017 ─ January 16, 2022).

Corresponding RSVs are reported in Figure 1 . Interestingly enough, symptoms such as anosmia and ageusia, but also conjunctivitis and dyspnea were characterized by a sustained surge in 2020, with a subsequent decrease in the following months. On the contrary, symptoms such as asthenia, coryza, sore throat, cough, diarrhea, headache, and nausea exhibited a sustained increase in 2021 compared to 2020. Despite significant outliers during the first months of the pandemic (i.e. spring 2020), visual inspection suggests that keywords such as cough, sore throat and even conjunctivitis (i.e. very common symptoms of When RSVs were compared with the 7-day mobile average for notification rates for SARS-CoV-2 (https://github.com/pcm-dpc/COVID-19/blob/master/dati-andamentonazionale/dpc-covid19-ita-andamento-nazionale.csv), a positive correlation calculated using Spearman's rank correlation coefficient was identified for all assessed search terms but conjunctivitis, sore throat, cough, and insomnia (Table 1 ). This stresses their substantial independence from the overall trend of the pandemic.

Eventually, RSVs for the timeframe December 1-January 16 were compared between the years 2020 and 2021 by means of Student's t test. An heterogeneous pattern was identified, with increased RSV for shivers/chills (+11.5%, p=0.012), pain/aches (+7.8%, p<0.001) and a substantial decrease for conjunctivitis (-17.7%, p<0.001), and even for sore throat (-10.2%, p=0.005) and headaches (-8.9%, p=0.016). However, no significant difference was scored for ageusia (+5.0%, p=0.358) and anosmia (-6.5%, p=0.254) as the Omicron VOC modified these clinical presentations compared to previous variants.

Our results are not only inconsistent with the previous report by Lippi et al. [4] , but they also show limited consistency with available conventional studies on the Omicron VOC [5] . Several explanations may be suggested. First of all, available reports suggest that in Internet search pattern, but a certain delay in RSV should be expected. Second, despite its potential significance, the predictive value of GT-based RSV analyses has been questioned by some studies [1] [2] as they can be influenced by main media [1, 7] . Not coincidentally, Figure 1 suggests that some of the search terms were associated with substantial outliers during the first months of the pandemic. While cough and sore throat were reasonable queries based on the most common symptoms of SARS-CoV-2 infections, more conflicting evidence suggests the association between COVID-19 and specific ophthalmologic manifestations. Even though ocular pain (31.2%) and eye discharge (19.2%) may be quite common features in SARS-CoV-2 cases [8] , redness and conjunctivitis are reported by around 1/10 of all cases, being relatively uncommon and unspecific signs. The sudden surge of new Internet searches may have actually been prompted by earlier claims [8] .

In other words, earlier claims about the specificities of the Omicron VOC, and more specifically the higher occurrence of mild flu-like symptoms, may have prompted similar Internet searches in the UK, eventually impairing the reliability of overall estimates. Furthermore, it should be stressed that 2021 has been characterized by an unprecedented surge of infections sustained by the respiratory syncytial virus, mainly in children, newborns, and institutionalized elderly people [9] [10] . Most search terms were characterized by a substantial seasonal trend, which in turn is reasonably associated with seasonal infectious diseases. We therefore cannot rule out that diseases other than SARS-CoV-2 may have influenced RSV estimates (either directly or indirectly) by interfering with the basal Internet searches. In conclusion, even though our analysis showed interesting differences between RSV for symptoms potentially associated with SARS-CoV-2, GT-based surveys cannot reasonably sustain claims for a progressive evolution of symptoms over time. More extensive, conventional studies are required. 

Reliability of Google Trends: Analysis of the Limits and Potential of Web Infoveillance During COVID-19 Pandemic and for Future Research

Anosmia-related internet search and the course of the first wave of the COVID-19 pandemic in the United States

Modeling the onset of symptoms of COVID-19: Effects of SARS-CoV-2 variant

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Is Google Trends a reliable tool for digital epidemiology? Insights from different clinical settings

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