key: cord-0763648-3pihg11q
authors: Rossi, Alfredo; Magri, Francesca; Michelini, Simone; Sernicola, Alvise; Muscianese, Marta; Caro, Gemma; Di Fraia, Marco; Chello, Camilla; Fortuna, Maria Caterina; Grieco, Teresa
title: New onset of alopecia areata in a patient with SARS‐CoV‐2 infection: Possible pathogenetic correlations?
date: 2021-03-25
journal: J Cosmet Dermatol
DOI: 10.1111/jocd.14080
sha: 1a6caa106a80ff24a792ce5d223cacf315602d05
doc_id: 763648
cord_uid: 3pihg11q

Coronavirus disease(COVID-19) has spread across the globe from December 2019 determining the current pandemic. It is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), an RNA virus of the betacoronavirus family. Besides COVID-19 respiratory symptoms, skin manifestations have been largely reported, such as chilblain-like lesions, urticaria, maculopapular lesions, and also hair loss(1).

Dear Editor, Coronavirus disease (COVID-19) has spread across the globe from

December 2019 determining the current pandemic. It is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), an RNA virus of the betacoronavirus family. Besides COVID-19 respiratory symptoms, skin manifestations have been largely reported, such as chilblain-like lesions, urticaria, maculopapular lesions, and also hair loss. 1 We report a case of alopecia areata(AA) which occurred after SARS-CoV-2 infection.

In October 2020, a female patient aged 29 was admitted to our post-COVID Dermatology Office, complaining progressive hair loss starting 6 months before our observation. The patient had been diagnosed with SARS-CoV-2 infection in March 2020, following positive naso-oropharyngeal swab test. Reported symptoms were fever and dry cough, treated with paracetamol and azithromycin and requiring no hospitalization.

The patient recalled that hair loss started 1 month after the onset of COVID-19, firstly on vertex and parietal regions, with patchy distribution, then involving the total scalp surface.

A trichological evaluation showed a generalized hair loss of the scalp, with regrowing hairs of different lengths ( Figure 1A 

SARS-CoV-2-induced telogen effluvium: a multicentric study

COVID-19: association with rapidly progressive forms of alopecia areata

Alopecia areata in a patient with SARS-Cov-2 infection

Evaluation of the relationship between alopecia areata and viral antigen exposure

Serum concentrations of IL-2, IL-6, IL-12 and TNF-α in patients with alopecia areata

Stress-induced premature senescence of dermal papilla cells compromises hair follicle epithelialmesenchymal interaction