key: cord-0762579-awxfolfy
authors: Driggin, Elissa; Morris, Alanna A.; Maddox, Thomas M.; Mullen, J. Brendan; Ferdinand, Keith C.; Parikh, Sahil A.; Kirkpatrick, James N.; Philbin, Daniel M.; Ky, Bonnie; Vaduganathan, Muthiah; Gluckman, Ty J.; Gulati, Chair Martha; Aggarwal, Niti R.; Kumbhani, Dharam J.; Bhave, Nicole M.; Krittanawong, Chayakrit; Dehmer, Gregory J.; Sala-Mercado, Javier A.; Gilbert, Olivia N.; Winchester, David W.
title: ACC Health Policy Statement on Cardiovascular Disease Considerations for COVID-19 Vaccine Prioritization
date: 2021-02-12
journal: J Am Coll Cardiol
DOI: 10.1016/j.jacc.2021.02.017
sha: 1fccce94896bd88afd4cf4a0a14a66d1043596ef
doc_id: 762579
cord_uid: awxfolfy

nan

The American College of Cardiology (ACC) has a long history of developing documents (e.g., decision pathways, health policy statements, appropriate use criteria) to provide members with guidance on both clinical and non-clinical topics relevant to cardiovascular care. In most circumstances, these documents have been created to complement clinical practice guidelines and to inform clinicians about areas where evidence may be new and evolving or where sufficient data may be more limited.

Despite this, numerous care gaps continue to exist, highlighting the need for more streamlined and efficient processes to implement best practices in service to improved patient care.

Central to the ACC's strategic plan is the generation of "actionable knowledge"-a concept that places emphasis on making clinical information easier to consume, share, integrate, and update. To this end, the ACC has evolved from developing isolated documents to developing integrated "solution sets".

Solution sets are groups of closely related activities, policy, mobile applications, decision support, and other tools necessary to transform care and/or improve heart health. Solution sets address key questions facing care teams and attempt to provide practical guidance to be applied at the point of care.

They use both established and emerging methods to disseminate information for cardiovascular conditions and their related management. The success of the solutions sets rests firmly on their ability to have a measurable impact on the delivery of care. Because solutions sets reflect current evidence and ongoing gaps in care, the associated tools will be refined over time to best match changing evidence and member needs.

Health Policy Statements (HPS) represent a key component of solution sets. The methodology for HPS is grounded in assembling a group of experts to develop content that addresses key policy issues facing our members. Topics selected for HPS vary widely, but connect to scientific, quality and/or advocacy efforts within the ACC. HPS are not written to provide clinical guidance; rather, they are J o u r n a l P r e -p r o o f As the largest professional society of cardiovascular (CV) professionals in the United States, the American College of Cardiology aims to offer specific guidance about how CV conditions contribute to the risk for adverse outcomes with COVID-19 infection to inform its membership and the patients they serve. In this policy document, we: 1) outline the overall considerations of both exposure and clinical risk needed for vaccine allocation efforts; 2) present the specific evidence and risk considerations related to CVD and COVID-19; and 3)

propose a schema of CV risk to incorporate into vaccine allocation decisions.

To provide this policy document, the American College of Cardiology convened a writing group with expertise in CVD, epidemiology, and risk assessment. We conducted a literature review of published reports relating to CVD and COVID-19. Where the literature was absent, we achieved consensus among the writing group. However, in some cases, there was insufficient evidence and/or experience to present an informed opinion, which needs to be considered in the interpretation of this document.

We attempted to include data from geographically diverse areas, when available, recognizing that variability in COVID-19 testing, treatment strategies, and in the prevalence of CV conditions can affect estimates of prevalence. It is also noteworthy that most published data have been retrospective in nature and have been conducted at various timepoints during the pandemic. As such, we attempted to emphasize data from larger meta-analyses, when available. It should be noted that our recommendations are based on limited data collected since the pandemic onset. Future recommendations may change over time with higher-quality data.

J o u r n a l P r e -p r o o f

Although the focus of this document is the specific clinical risk associated with CV risk factors and disease in COVID-19, it is important to place these recommendations into the broader context of vaccine allocation decisions (Central Illustration). These decisions should incorporate both the exposure risk for COVID-19 infection and the clinical risk of experiencing severe COVID-19-related health outcomes. In addition, there are glaring disparities in COVID outcomes between racial/ethnic groups and different socioeconomic status levels, partly due to differential exposures and clinical risks and partly due to overall inequities in health care access and social determinants of health. All of these factors warrant consideration in vaccine allocation decisions.

Exposure risk for COVID-19 correlates with the amount of time spent interacting closely with others and on the number of these interactions. As such, exposure risk is higher among health care workers, first responders, public transportation employees, and other "essential" workers. Evidence suggests that this risk can be reduced by adherence to CDC recommendations for mask-wearing and social distancing (3). Frequency of health care system interaction is another factor that may be considered to influence exposure risk among patients.

For example, patients with advanced CVD may require long-term stays in nursing homes or rehabilitation centers. As such, their risk of COVID-19 exposure may increase. Finally, the local prevalence rates of COVID-19 infection, which vary by community, also influence exposure risk.

Clinical risk for severe COVID-19 infection appears to correlate with both advanced age and preexisting medical conditions. Advanced age in itself, with its decreased physiological J o u r n a l P r e -p r o o f reserve, leads to a higher susceptibility to contracting COVID-19 and experiencing its complications (4, 5) . Additionally, advanced age is a surrogate for more numerous comorbidities, resulting in greater risk and worse outcomes. Reports by the CDC demonstrate that compared with patients 18-29 years of age with COVID-19, those over 75 years of age have an 8-fold higher risk of hospitalization and 220-fold higher risk of death (6) . As such, the current CDC phased allocation model prioritizes patients with advanced age for early vaccination, which is in accordance with the CV-related risk related to advanced age.

Preexisting medical conditions, particularly when 2 or more co-occur, also significantly increase the risk for severe COVID-19 outcomes. In a large systemic review of the literature including 202,005 patients with COVID-19, the case fatality rate (CFR) rose incrementally with the number of comorbidities: whereas patients with 1 medical comorbidity experienced a CFR of 6%, patients with 6 or more comorbidities experienced a CFR of 21% (7) . In addition to multimorbidity, there are data demonstrating the adverse effects of frailty in patients with COVID-19. A multicenter European study of 1,564 adult subjects assessed using the clinical frailty scale (1-2 = fit; 3-4 = vulnerable, but not frail; 5-6 = initial signs of frailty but with some degree of independence; and 7-9 = severe or very severe frailty) found that higher levels of frailty were associated with worse adjusted 7-day mortality, independent of age and comorbidity (8) . Given this collective evidence, older patients with multiple comorbidities, including CV conditions, and/or frailty should be considered at high risk and thus prioritized for

Finally, it is imperative to recognize the racial, ethnic, and socioeconomic disparities that may influence the risk for adverse outcomes, including mortality, in COVID-19 (9) (10) (11) . Reports J o u r n a l P r e -p r o o f from the CDC show that compared with age-adjusted standardized mortality rates, the risk of death from COVID-19 increased by nearly 3-fold in Blacks, non-Black Hispanics/Latinos, and American Indians/Alaskan Natives (12) . The reasons behind these disparities are multifactorial.

First, the exposure risk among these populations tends to be higher, given the higher prevalence of multigenerational households and "essential" jobs necessitating more frequent contact with the public. Second, patients in racial and ethnic minority populations have a higher prevalence of CV risk factors and disease and therefore are at higher clinical risk compared with those without comorbidity (13, 14) . Higher transmission rates are also observed among those who experience social inequalities (15) . Third, health care accessibility is another important driver of these disparities. The number of hospitals, intensive care unit (ICU) beds, and other resources important to the care of patients with COVID-19 vary by region of the country and are typically lower in communities of color, settings of poverty, and in rural locations. As such, the demand for resources may outweigh the supply, affecting the triage and management of patients COVID-19 (16) .

A coherent vaccine allocation strategy will consider the exposure risks and clinical risks of given individuals and populations. In addition, it will take into account those demographic populations that, for a variety of reasons, have additional risks that lead to higher rates of COVID-19 infection and severe health outcomes. Finally, the vaccine allocation strategy should balance the use of complex, multifactorial risk stratification with the exigency of operationalizing the most rapid and efficient plan to achieve population immunity and blunt community spread. Poorly controlled hypertension defined as >140/90mmHg. Poorly controlled diabetes defined using A 1c >10%.

Overweight defined as BMI 25-29; obese defined as BMI 30-40, morbidly obese defined as BMI >40.

Obstructive CAD defined using >70% obstruction in major epicardial arteries, >50% in left main coronary artery.

High grade PAD defined using ABI >0.5.

Malignant tachyarrhythmia include atrial fibrillation with poor rate control and/or VT with prior ICD therapy or antiarrhythmic medication.

With the broad context of considerations for COVID-19 vaccine allocation articulated, we now focus on the specific contributions of CV conditions to COVID-19 infection and severity.

Numerous multinational studies have demonstrated that CVD and its related risk factors are associated with high morbidity and mortality in patients with COVID-19 infection. (17) (18) (19) (20) (21) (22) (23) (24) (25) (26) .

Furthermore, the association between CVD and poor outcomes in COVID-19 has been demonstrated to exist independent of potential confounders (27) . In a large meta-analysis of 21 multinational studies inclusive of 11,766 COVID-19 cases, CVD was an independent predictor of severe COVID-19, even after controlling for age and sex (relative risk [RR]: 1.8, 95% CI: 1.1-2.7) (28) . Additionally, the presence of CVD is a key risk factor for the CV complications of COVID-19, which are also associated with increased morality (29, 30) . Below, we review the available data regarding the prevalence and association of specific CV conditions and risk factors with outcomes in patients with COVID-19.

Since the earliest cohort studies from China, hypertension has been consistently reported as a common CV comorbidity in patients with COVID-19 (31) (32) (33) (34) . In a large U.S. cohort study using hospital claims data for 11,721 patients across 38 states, pre-existing hypertension was noted in 46.7% of COVID-positive patients (21) . In a critically-ill cohort of 257 patients from New York City, the prevalence of pre-existing hypertension among patients in the ICU was even higher, at 63.0% (35) .

Although the baseline prevalence of hypertension varies significantly by geographic region, multinational data have consistently demonstrated worse outcomes associated with COVID-19

in patients with pre-existing hypertension (23, 33) . In a large meta-analysis from (37) . Although the majority of these studies are from China, we believe that these associations are likely generalizable to other geographic populations, including those in the United States. Therefore, patients with hypertension, and especially those with poorly controlled disease with older age and additional comorbidities, should be considered to have elevated risk of adverse outcomes associated with COVID-19.

Diabetes Diabetes mellitus is a highly prevalent CV risk factor among patients with COVID-19. In a large cohort study using medical record data including 31,461 patients from 24 U.S. health care systems, diabetes was present in 15% of patients with COVID-19 (9) . In this analysis, diabetes was the second most common medical comorbidity overall, aside from pre-existing pulmonary disease, which was prevalent in 17.5% of patients (9) . Among hospitalized patients, large cohort studies from different areas of the United States demonstrate even higher prevalence, ranging from 25.2% to 35.8% (21, 35, 38, 39) . Although the prevalence of diabetes at baseline varies significantly by country, cohort studies from various nations around the world all demonstrate diabetes to be a prevalent comorbidity in patients with COVID-19 (33, 34, 40, 41) .

Limited data demonstrate an association between diabetes and adverse outcomes in (42) . Similar associations were observed in a population-based study from Scotland (43) .

The severity of diabetes is also related to adverse outcomes in COVID-19 (44) . In a population-based study among over 16,000 patients with diabetes in England, those with a J o u r n a l P r e -p r o o f glycosylated hemoglobin (HbA 1c ) level greater than 10% had higher mortality compared with those with an HbA 1c level between 6.5% and 7.0% (HR: 2.23; 95% CI: 1.50-3.30) (45) . Patients with insulin dependence, poor glycemic control, and/or microvascular and macrovascular complications from diabetes should be considered at especially high risk for adverse outcomes associated with COVID-19.

Obesity is a highly prevalent CV risk factor in the United States and, as such, much of the data for adverse outcomes in patients with obesity and COVID-19 come from cohort studies in the United States. Among 11,721 patients hospitalized for COVID-19 across 38 states, 16% of patients were obese (body mass index [BMI] ≥30) (21) . However, in certain regions, obesity is even more prevalent. Two New York City cohort studies demonstrated obesity in approximately one-third of inpatients admitted with COVID-19 (38, 39) . In a cohort study of critically-ill patients admitted to the ICU in New York City, 46% of patients were obese (26) .

Small studies have demonstrated that pre-existing obesity has been consistently associated with adverse outcomes in COVID-19. Among 393 patients hospitalized for COVID-19

in New York City, patients with obesity were more likely to be intubated compared with patients without obesity (43.4% vs 31.9%) (38) . Even among a cohort of young adults with COVID-19, morbid obesity (BMI >40) was independently associated with death or mechanical ventilation during hospitalization (46) . A larger national study using hospital claims data from the majority of states also showed this association of obesity with a greater need for mechanical ventilation (18.3% vs 15.7%) (21) . Interestingly, in a cohort study of 6,916 patients J o u r n a l P r e -p r o o f from Kaiser Permanente hospitals in California, the association between BMI and mortality related to COVID-19 was J-shaped, with higher risks in patients with either low or elevated BMIs (47) . Specifically, low BMI (<18.5 kg/m 2 ) was associated with worse outcomes (RR: 1.81; 95% CI: 0.99-3.30), likely due to frailty or cachexia related to comorbid conditions (47) . In addition, hospitalization with increasing BMI (48), thus supporting the U.S. data. Accordingly, we recognize obesity as an important CV risk factor and postulate the risk of obesity to be incremental, such that patients with morbid obesity are at the highest risk for poor outcomes associated with COVID-19. Furthermore, it is important to recognize that obesity contributes to other risks such as hypertension, diabetes, sleep apnea, and secondary pulmonary hypertension.

Although the data from China demonstrated pre-existing atherosclerotic cardiovascular disease (ASCVD) in a only small minority of patients with COVID-19, studies from the United States demonstrate ASCVD to be a more common CV comorbidity, likely due to higher baseline prevalence (40) . Data from inpatients and outpatients with COVID-19 in a large New York City health system reported an 8.6% prevalence of pre-existing coronary artery disease (CAD) and an 8.1% prevalence of peripheral artery disease (PAD) (49) . In another New York City cohort of 393 patients hospitalized with COVID-19, the prevalence of pre-existing CAD was even higher, at 13.7% (38) .

The presence of ASCVD has been shown in multiple analyses to be associated with adverse outcomes with COVID-19 infection. In a federated electronic medical record analysis of multiple U.S. centers, prior myocardial infarction was associated with higher odds of death from (50) . At the present time, data supporting a connection between cerebrovascular disease and adverse COVID-19 outcomes are lacking. Nonetheless, the presence of ASCVD appears to be a clear risk factor for poor outcomes in COVID-19. Furthermore, we believe that patients with extensive, high-risk ASCVD are the most susceptible to adverse outcomes. Interestingly, an association between atrial fibrillation (AF) and elevated angiotensin-converting enzyme 2 (ACE2) levels has led to speculation that patients with known AF may have a higher risk for morbidity and mortality associated with COVID-19 (51) (52) (53) . Certain populations with AF have a higher risk for morbidity and mortality from arrhythmia recurrence, which COVID-19 seems to provoke (54, 55) . For example, patients with a known history of a tachycardia-induced cardiomyopathy or diastolic heart failure exacerbation related to AF should be considered at high risk. Those patients in persistent or permanent AF or flutter with marginal rate control should also be considered at higher risk than those who are well rate-controlled and prioritized appropriately. Data regarding other supraventricular tachycardias are less clear. Notably, despite the known thrombotic complications of COVID-19, anticoagulant therapy before admission, commonly used to prevent stroke in patients with AF, does not appear to have an impact on mortality in hospitalized patients (56, 57) .

The effect of COVID-related illness on patients with preexisting ventricular arrhythmias has not been reported in large series. Clinical experience suggests that pulmonary decompensation from any cause can be associated with recurrent ventricular arrhythmias including ventricular tachycardia and ventricular fibrillation (VT or VF) and therapy from implanted cardioverter-defibrillators (ICDs) (54, 58) . Markers that might reasonably be expected to confer increased risk include a history of appropriate ICD therapy for VT or VF or a requirement for longitudinal treatment with an antiarrhythmic medication to achieve clinical J o u r n a l P r e -p r o o f suppression. Patients in those categories should reasonably be considered at high risk for adverse outcomes with COVID-19.

In distinction to many other CVDs, there is robust evidence for poor outcomes in COVID-19

in the presence of preexisting heart failure. Among a cohort of 31,461 patients with COVID-19 across the United States, 7.3% had a history of heart failure (9) . Compared with those who survived, those who died had a significantly higher proportion of preexisting heart failure (30.8% vs 6.3%). In a multivariable model controlling for relevant demographic and CV risk factors, preexisting heart failure was independently associated with death in this cohort (OR:

1.42: 95% CI: 1.21-1.67). These findings have been replicated in 2 large New York City cohorts as well (49, 59) . In an analysis of 1,212,153 patients with heart failure who were included in the Premier health care database, patients with heart failure who were hospitalized for COVID-19 had markedly greater risk for in-hospital mortality in multivariable analysis (OR: 14.48: 95% CI:

12.23-17.12) (60). In multivariable models for the outcomes of death or mechanical ventilation, preexisting heart failure was also a significant independent risk factor (OR: 8.04: 95% CI: 7.10-9.12). Notably, these associations were persistent over 2 distinct time periods in the pandemic, though overall mortality was lower later in the pandemic. Therefore, heart failure is a clear, established risk factor for poor outcomes, and patients who are decompensated and/or with poor functional status should be considered at the highest risk. Among 13 patients with a history of heart transplantation in Michigan, 6 required ICU admission and 2 died (63) . In a slightly larger New York City cohort of 28 patients with prior heart transplants and COVID-19, 22 required hospitalization, of whom 7 required mechanical ventilation and 7 died (64) . Given these data and the immunosuppressed status of these patients, patients with a history of heart transplantation are at especially high risk for COVID- 19 . Patients who are actively listed for heart transplants in the hospital or at home should also be presumed to be at high risk. Furthermore, those patients with durable mechanical support, such as left ventricular assist devices, should also be presumed to be at high risk, regardless of transplant candidacy.

Patients with pulmonary hypertension (PH) have an increased risk of death with COVID-19 infection, though the data are limited. One group surveyed 77 U.S. PH comprehensive care centers, noting that although the incidence of COVID-19 infection in patients with PH was J o u r n a l P r e -p r o o f similar to that of the general U.S. population (2.9 per 1,000 patients), their rates of hospitalization were higher, at 30% (65) . Furthermore, mortality was significantly higher compared with the general population, at 12%. The authors allude to the important point that in addition to the potential direct harm associated with COVID-19, patients with PH had fewer clinic visits and limited diagnostic testing during the pandemic, indicating potential indirect effects on disease progression and monitoring. Although there are no studies that examine the impact of PH severity on disease outcomes, it is likely that those patients with advanced disease and/or those undergoing lung transplant evaluation are at especially high risk for poor outcomes with COVID-19.

There are very limited data thus far on the association between adult congenital heart disease (ACHD) and outcomes in patients with COVID-19. Given the variable anatomy and functional status associated with different forms of ACHD, the risk for poor outcomes in COVID-19 is heterogeneous within this population. A single-center New York City cohort study examined outcomes among 53 patients with congenital heart disease, 43 (81%) of whom were adults (66) . Seven patients (5.7%) died of COVID-19 in this cohort. Patients classified as physiological stages C or D, indicating more clinically severe disease, had significantly higher mortality than those with better clinical status (OR: 19.4) . Notably 36% of patients with ACHD had associated heart failure (40% of adults), 11% had PH, and 17% were obese, all of which significantly increased the risk for death in this cohort, whereas lesion type and lesion complexity were not associated with outcomes. Although larger multicenter studies are J o u r n a l P r e -p r o o f needed, patients with ACHD, especially those with concomitant heart failure and/or PH and those with poor physiological stage, are at the highest risk with COVID-19 infection.

There are many patients with preexisting CVD who have important coexisting medical conditions that together likely influence the risk for morbidity and mortality in COVID-19. For example, patients with CVD and comorbid pulmonary disease are likely to have poor outcomes with COVID-19, given the severe impact of the virus on both organ systems. Similarly, patients with CVD and comorbid chronic kidney disease are likely to experience poor outcomes.

Furthermore, patients with CVD and active and prior malignancies likely represent a high-risk group, given their poor performance status, immunocompromised status, and/or hypercoagulability, which may portend CV complications associated with COVID-19 (67) .

Pregnant women with CVD should also be considered high risk, given the potential for pregnancy to decompensate certain CVDs, such as heart failure, that may be exacerbated in the setting of COVID-19 infection. In addition to other non-CV comorbidities, other behaviors may amplify CV risk, such as smoking, medical noncompliance, and alcohol or substance abuse.

Although these interactions are all important to consider, more data are needed to make recommendations for these specific populations.

Based on epidemiological evidence to date defining the morbidity and mortality of COVID-19 and the expert consensus of the writing group, we outline a proposed vaccine allocation schema with regard to CV risk (Central Illustration). Our proposed vaccine allocation schema outlines key CV clinical risk considerations within the broader context of key overall risk J o u r n a l P r e -p r o o f considerations including exposure, disparities, health care access, advanced age, and multimorbidity. Individual risk should be determined by their highest-risk CV condition.

Importantly, this schema does not suggest that individuals with lower-risk CV conditions should delay or avoid receiving the vaccine. Rather, its intent is to emphasize that those with relatively higher-risk CV conditions should prioritize their receipt of the vaccine. Accordingly, their care teams should encourage prompt vaccination and proactively address any barriers or hesitancy that the patient may be facing.

Patients with CV risk factors and disease are at variable risk for adverse outcomes in COVID-19 based on the severity of their comorbidities. Patients with more advanced CVD are at higher risk compared with those with well-controlled CV conditions (36, 66) . For example, those patients with poorly controlled hypertension, insulin-dependent diabetes, or diabetes with microvascular and/or macrovascular complications as a result of poor glycemic control should be considered higher risk compared with patients who are medically optimized. Similarly, patients with morbid obesity should be considered higher risk compared with patients who are overweight. Patients with high-risk or symptomatic ASCVD, including CAD or PAD, should be considered at higher risk compared with patients with asymptomatic or fully revascularized disease. In patients with a history of cardiac dysrhythmia, those with poorly controlled or poorly tolerated AF/flutter should be considered at higher risk. Furthermore, those patients with a history of VT or VF previously requiring ICD therapy and/or longitudinal treatment with an antiarrhythmic medication should be considered at higher risk as well. Among patients with heart failure, those with worse functional status (ie, New York Heart Association class III/IV) and those requiring recent hospitalization or an urgent visit for worsening heart failure should be J o u r n a l P r e -p r o o f considered higher risk compared with those patients who are well-compensated on medical therapy and infrequently hospitalized. Patients with heart failure who are being considered for or are already listed for a heart transplant should be considered at especially high risk, given their advanced, decompensated disease. Additionally, patients with a history of a heart transplant should be considered higher risk, given their immunosuppressed status, especially those in the immediate post-operative state and at the highest intensity of immunosuppression. Although there are less data in the PH population, patients with moderate-severe PH should be considered higher risk, especially those who are decompensated and being considered or listed for lung transplant. Patients with ACHD with advanced physiological stage, indicating more advanced disease, should be prioritized. We hope that this document can be used to guide COVID-19 vaccine allocation and patient outreach in the context of prolonged demand-supply mismatch as we enter Phase 1c.

J o u r n a l P r e -p r o o f

Centers for Disease Control and Prevention. Evidence Table for COVID-19 Vaccines Allocation in Phases 1b and 1c of the Vaccination Program

Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy

Comorbidities, clinical signs and symptoms, laboratory findings, imaging features, treatment strategies, and outcomes in adult and pediatric patients with COVID-19: A systematic review and meta-analysis

COVID-19 Hospitalization and Death by Age

The epidemiological burden and overall distribution of chronic comorbidities in coronavirus disease-2019 among 202,005 infected patients: evidence from a systematic review and meta-analysis

The effect of frailty on survival in patients with COVID-19 (COPE): a multicentre, European, observational cohort study

Comorbidities associated with mortality in 31,461 adults with COVID-19 in the United States: A federated electronic medical record analysis

Racial disparities in COVID-19 mortality are driven by unequal infection risks

Disparities in the population at risk of severe illness from COVID-19 by race/ethnicity and income

Cases, Data & Surveillance: COVID-19 Hospitalization and Death by Race/Ethnicity

Association of race and ethnicity with comorbidities and survival among patients with COVID-19 at an urban medical center

Hospitalization and mortality among black patients and white patients with Covid-19

COVID-19 and the impact of social determinants of health

Scarce-resource allocation and patient triage during the COVID-19 pandemic: JACC Review Topic of the Week

Cardiovascular considerations for patients, health care workers, and health systems during the COVID-19 pandemic

COVID-19 and cardiovascular disease

Potential Effects of coronaviruses on the cardiovascular system: a review

COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives

Patient characteristics and outcomes of 11,721 patients with COVID19 hospitalized across the United States

Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19)

Severity and mortality of COVID 19 in patients with diabetes, hypertension and cardiovascular disease: a meta-analysis

Association of cardiovascular disease and 10 other pre-existing comorbidities with COVID-19 mortality: A systematic review and meta-analysis

Risk factors of critical & mortal COVID-19 cases: a systematic literature review and meta-analysis

Study of critically ill patients with COVID-19 in New York City -Authors' reply

Underlying heart diseases and acute COVID-19 outcomes

The relationship of COVID-19 severity with cardiovascular disease an iIts traditional risk factors: a systematic review and metaanalysis

Impact of cardiovascular risk profile on COVID-19 outcome. A meta-analysis

Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China

Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China

Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis

Baseline characteristics and outcomes of 1591 patients infected with SARS-CoV-2 admitted to ICUs of the Lombardy Region

Clinical characteristics of hospitalized individuals dying With COVID-19 by age group in Italy

Epidemiology, clinical course, and outcomes of critically ill adults with COVID-19 in New York City: a prospective cohort study

Association of hypertension and antihypertensive treatment with COVID-19 mortality: a retrospective observational study

Blood pressure control and adverse outcomes of COVID-19 infection in patients with concomitant hypertension in Wuhan, China

Presenting characteristics, comorbidities, and outcomes among 5700 patients hospitalized with COVID-19 in the New York City area

Clinical characteristics of coronavirus disease 2019 in China

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study

Risks of and risk factors for COVID-19 disease in people with diabetes: a cohort study of the total population of Scotland

Assessment of risk, severity, mortality, glycemic control and antidiabetic agents in patients with diabetes and COVID-19: A narrative review

Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study

Clinical outcomes in young US adults hospitalized with COVID-19

Obesity and mortality among patients diagnosed with COVID-19: results from an integrated health care organization

Overweight, obesity, and risk of hospitalization for COVID-19: A community-based cohort study of adults in the United Kingdom

Cardiovascular comorbidities, cardiac injury, and prognosis of COVID-19 in New York City

Risk factors of fatal outcome in hospitalized subjects with Coronavirus Disease 2019 from a nationwide Analysis in China

Angiotensin converting enzyme 2 activity and human atrial fibrillation: increased plasma angiotensin converting enzyme 2 activity is associated with atrial fibrillation and more advanced left atrial structural remodelling

Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation

Should atrial fibrillation be considered a cardiovascular risk factor for a worse prognosis in COVID-19 patients?

Guidance for cardiac electrophysiology during the COVID-19 pandemic from the Heart Rhythm Society COVID-19 Task Force

Electrophysiology Section of the American College of Cardiology; and the Electrocardiography and Arrhythmias Committee of the Council on Clinical Cardiology

COVID-19 associated atrial fibrillation: Incidence, putative mechanisms and potential clinical implications

Impact of anticoagulation prior to COVID-19 infection: a propensity score-matched cohort study

Anticoagulation outcomes in hospitalized Covid-19 patients: A systematic review and meta-analysis of case-control and cohort studies

AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the

Risk factors and outcomes of COVID-19 in New York City; a retrospective cohort study

Clinical outcomes in patients with heart failure hospitalized with COVID-19

COVID-19 in heart transplant recipients: a multicenter analysis of the Northern Italian Outbreak

COVID-19 among heart transplant recipients in Germany: a multicenter survey

Coronavirus Disease-2019 in heart transplant recipients in southeastern Michigan: a case series

Characteristics and outcomes of recipients of heart transplant with coronavirus disease 2019

A Survey-based estimate of COVID-19 incidence and outcomes among patients with pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension and impact on the process of care

Impact of coronavirus disease 2019 (COVID-19) on patients with congenital heart disease across the lifespan: the experience of an academic congenital heart disease center

Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study

KEY WORDS: hypertension, diabetes, obesity, coronary artery disease, cardiac arrhythmias

To avoid actual, potential, or perceived conflicts of interest that may arise as a result of industry relationships or personal interests among the writing committee, all members of the writing committee, as well as peer reviewers of the document, are asked to disclose all current healthcare-related relationships, including those existing 12 months before initiation of the writing effort. The Solution Set Oversight Committee reviews these disclosures to determine what companies make products (on market or in development) that pertain to the document under development. Based on this information, a writing committee is formed to include a majority of members with no relevant relationships with industry (RWI), led by a chair with no relevant RWI. RWI is reviewed on all conference calls and updated as changes occur. Author RWI pertinent to this document is disclosed in the table below and peer reviewer RWI is disclosed in Appendix 2. Additionally, to ensure complete transparency, authors' comprehensive disclosure information-including RWI not pertinent to this document-is available in a Supplemental Appendix. Disclosure information for the ACC Solution Set Oversight Committee is available online at http://www.acc.org/guidelines/about-guidelines-and-clinical-documents/guidelines-and-documents-task-forces, as well as the ACC disclosure policy for document development at http://www.acc.org/guidelines/about-guidelines-and-clinical-documents/relationships-with-industry-policy. 

This