key: cord-0758947-wfcf5u3h
authors: Potdar, Shweta; Pal, Nikita; Sharma, Pratibha; Kumar, Ashok
title: The catalytic influence of phosphotungstic acid-functionalized Fe(3)O(4) MNPs blended with TiO(2) on the synthesis of novel spiro-acridines and the evaluation of their medicinal potential through molecular docking studies
date: 2020-12-16
journal: RSC advances
DOI: 10.1039/d0ra06975b
sha: 0a7a67c54901f5affbce10d86beb560c64e0dd73
doc_id: 758947
cord_uid: wfcf5u3h

This manuscript describes an effective and rapid three-component synthesis of a novel series of spiro-acridine derivatives by integrating the pharmacologically dynamic hydantoin–phenytoin as the prime synthetic equivalent. The process was accelerated by Fe(3)O(4)@TiO(2)-PTA magnetic nanoparticles (MNPs), which acted as the heterogeneous catalytic system, under ultrasonic conditions. The reaction was performed in the green PEG-200 solvent under aerophilic conditions to obtain products with excellent yields. The characteristics of the synthesized magnetic nano-catalysts were corroborated through powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDAX), FT-IR, and VSM techniques. In addition, the structures of the synthesized compounds were ascertained on the basis of elemental analyses and spectro-analytical data ((1)H NMR, (13)C NMR, and mass spectrometry). High yields, smaller E-factor, considerable atom economy, easy recovery, and recyclability of the catalyst and solvent are the captivating features of the developed protocol. Moreover, in view of the ongoing global research on COVID-19, herein, we tried to identify the potential sites of the synthesized moiety that can suitably fit the receptor sites of the main protease of SARS-CoV-2 (SARS-CoV-2 M(pro)).

Mass spectrum of (4a) 3,3,6,6-tetramethyl-4',4'-diphenyl-10-(p-tolyl)-3,4,6,7-tetrahydro-1H-spiro[acridine-9,2'imidazolidine]-1,5',8(2H,5H,10H)-trione 

Magnetic Field (Oe)