key: cord-0758777-c0p33sla authors: Mattioli, Anna V; Farinetti, Alberto title: Comment on “Western Dietary Pattern Antioxidant Intakes and Oxidative Stress: Importance during the SARS-CoV-2/COVID-19 Pandemic” date: 2021-06-01 journal: Adv Nutr DOI: 10.1093/advances/nmab029 sha: 3f1c1799b1851eb4b06505e47b675536ec70520d doc_id: 758777 cord_uid: c0p33sla nan study. Thus, in contrast to the authors' interpretation (1), we deemed the effect to be trivial not in relation to generalized, heuristic definitions, but in relation to expected effect sizes for apparently similar interventions. Moreover, to directly address the authors' query, the unstandardized meta-analytic effect of coaching on weight loss was −1.4 kg [95% credible interval (CrI): −3.0, −0.1]. Considering only the highestquality studies, the effect was −1.1 kg (95% CrI: −3.1, 1.1). Although there is room for discussion about what constitutes meaningful weight loss in different contexts, we believe most would agree that these average effects are, indeed, trivial. The root of the discrepant outcomes found in our study and in the compendium is methodological in nature. While we assessed the quality of studies using a clear systematic approach, and in accordance with GRADE recommendations, their compendium (3) did not use a systematic approach to assess either study quality or effect magnitude. The authors' conclusion that health coaching is beneficial for treating obesity is based on the observation that "A large portion of the studies showed a positive effect on weight reduction" (3). This is not a valid assertion, particularly considering the publication bias identified in our study. This highlights the need for exploring the potential impact of conflicts of interest on health coaching literature, in which objective research by those with no vested interest should be important. To conclude, our findings represent a first attempt to systematically assess the health coaching literature. The main conclusions are that most of the studies present serious methodological flaws and divergent theoretical backgrounds, hampering the clinical use of this technique in an effective, uniform way. This is not to say that health coaching cannot be an effective and well-structured intervention. A few good examples on how this strategy can be a useful co-adjuvant therapy in obesity management do exist (9, 10) . Expanding the number of high-quality studies, with detailed information of their interventions and reporting on all aspects of their study design, is essential to pave the way for a more evidence-based use of health coaching in clinical practice. Simply incorporating any lifestyle behavioral intervention under the obscure umbrella of health coaching will not help build a scientifically oriented body of knowledge. amounts of antioxidants to maintain the immune system during the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/coronavirus disease 2019 (COVID-19) pandemic. Viral infections are characterized by high oxidative stress and an appropriate intake of antioxidants would help to fight against the virus. The authors suggested that lifestyle factors could influence the impact of the disease. With reference to the findings reported in the article, we would like to make the following contribution to the discussion. The review analyzes in depth the potential beneficial effects of a healthy diet, including a Mediterranean Diet, on viral infection. In recent articles we also supported the idea that a healthy lifestyle could contribute to a higher immune response to the virus and would therefore be beneficial in the fight against the pandemic (2, 3). It has been suggested that there would be a synergy among the antioxidant-rich foods that would foster favorable changes in inflammatory pathways (4). Humans do not consume 1 type of food but a wide variety of combinations of different foods forming a dietary pattern. Consequently, in analyzing eating habits it is mandatory to take the interactions between different foods and their components into consideration. Moreover, it is known that plant-derived phenolic compounds could differently influence the health of males and females (5) . The recent COVID-19 pandemic strongly affected women owing to increased psychological distress leading to unhealthy lifestyles, and women were specifically more likely to develop food cravings (2, 6, 7) . Food cravings are characterized by a high intake of fat-and sugar-rich foods and by a low intake of fruit and vegetables. In a previous article (2) we hypothesized that vitamin D prophylaxis can help reduce the severity of the disease caused by SARS-CoV-2, particularly in contexts where hypovitaminosis D is common, i.e., women currently living in Northern countries (8) . Several factors may have contributed to the widespread infection in Italy, despite the strong adherence to the Mediterranean diet. Lifestyle and diet can influence our inflammatory response to the virus and therefore it is important that both are optimized. The review by Trujillo-Mayol et al. (1) emphasizes these aspects of prevention but does not emphasize the potential increased risk in women. Women's health is strongly influenced by lifestyle, which includes dietary pattern and nutritional status, physical activity, and socioeconomic stress. A healthy lifestyle is mandatory to prevent chronic diseases and to fight infections. Women are less likely to adopt a healthy lifestyle owing to the high social pressures that oblige women to play numerous roles in the family, in society, and at work, all of which are debilitating and time consuming (9, 10) . We need educational programs and prevention measures specifically dedicated to women's health. Comment on "Health Coaching: 100 Strategies for Weight Loss: A Systematic Review and Meta-Analysis Health coaching strategies for weight loss: a systematic review and meta-analysis Compendium of health and wellness coaching: 2019 addendum A self-regulation lifestyle program for post-cardiac rehabilitation patients has long-term effects on exercise adherence Effects of telephone-based motivational interviewing in lifestyle modification program on reducing metabolic risks in middleaged and older women with metabolic syndrome: a randomized controlled trial Motivational interviewing with problem drinkers Motivational interviewing: a systematic review and meta-analysis Motivational interviewing to improve weight loss in overweight and/or obese patients: a systematic review and meta-analysis of randomized controlled trials Efficacy of health coaching and a webbased program on physical activity, weight, and distress management among cancer survivors: a multi-centered randomised controlled trial Western dietary pattern antioxidant intakes and oxidative stress: importance during the SARS-CoV-2/COVID-19 pandemic Obesity risk during collective quarantine for the COVID-19 epidemic COVID-19 pandemic: the effects of quarantine on cardiovascular risk Polyphenols are potential nutritional adjuvants for targeting COVID-19 Put "gender glasses" on the effects of phenolic compounds on cardiovascular function and diseases Food craving: new contributions on its assessment, moderators, and consequences Cardiovascular prevention in women: a narrative review from the Italian Society of Cardiology working groups on 'Cardiovascular Prevention, Hypertension and peripheral circulation' and on 'Women Disease A review of the critical role of vitamin D in the functioning of the immune system and the clinical implications of vitamin D deficiency Prevention of cardiovascular risk factors in women: the lifestyle paradox and stereotypes we need to defeat Lifestyle and stress management in women during COVID-19 pandemic: impact on cardiovascular risk burden Western Dietary Pattern Antioxidant Intakes and Oxidative Stress: Importance during the SARS-CoV-2/COVID-19 ) present their argument for increasing dietary antioxidant intake to improve coronavirus disease The authors reported no funding received for this letter. Author disclosures: The authors report no conflicts of interest. All authors read and approved the final manuscript. Author disclosures: The authors report no conflicts of interest. We thank Mrs. Janet Ann Carter for reviewing and editing the letter.