key: cord-0754807-55e32uaw
authors: Emani, Venkata R.; Reddy, Raghunath; Goswami, Kartik K.; Nakka, Abirath S.; Emani, Shaila R.; Reddy, Nikhila K.; Maddula, Kailash R.; Nandanoor, Dheeraj; Goswami, Sanjeev
title: Preexisting conditions among the SARS-CoV2 deaths during the SARS-CoV2 B.1.617.2 (Delta variant) outbreak in the United Kingdom
date: 2022-02-25
journal: J Glob Antimicrob Resist
DOI: 10.1016/j.jgar.2022.02.014
sha: 2d77db21fd418c511d3fe42e99ddd5aa1ca4c889
doc_id: 754807
cord_uid: 55e32uaw

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. The relative risk (RR), and 95% confidence interval and P value was calculated to compare these outcomes prior to and during the Delta variant surge. RR is calculated using the formula, p value (<0.05) was considered significant for the differentiation between the groups. Our study demonstrates that the preexisting conditions associated with majority of deaths among elderly over 60 years old population with slight increase in deaths without preexisting conditions especially among younger population during the Delta variant surge. Our study included the detailed analysis of a large sample of 94,624 SARS-CoV2 deaths from the NHS database of UK among various age groups. Limitations of our study is, it is an observational retrospective study of publicly reported data and the generalizability of the findings are limited to the UK population. Additionally, we are unable to analyze the mode of COVID-19 deaths and timing of deaths relative to the onset of symptoms and or hospitalization as that information is not available.

In conclusion, the majority of deaths (93.5%-94.8%) among more than 60 years old age groups during the Delta variant surge were associated with preexisting conditions with a slight, but statistically significant increased proportion of deaths without preexisting conditions (7.7% vs 4.1%) during the Delta variant surge than before with majority of this slight increase seen among 20-39 and 40-59 year age group deaths. 

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

Preexisting Comorbidities Predicting COVID-19 and Mortality in the UK Biobank Community Cohort

Comorbidities associated with mortality in 31,461 adults with COVID-19 in the United States: A federated electronic medical record analysis

SARS-CoV-2 variants of concern and variants under investigation in England: technical briefing 18

COVID-19 Weekly Total Deaths Archive

The authors have no conflict of interest or financial relationships relevant to the submitted review to disclose.Funding source: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sector Ethical Approval statement: None required