key: cord-0751592-f4gh2mjz authors: Pal, Sanjoy; Chowdhury, Trinath; Paria, Kishalay; Manna, Sounik; Parveen, Sana; Sing, Manjeet; Sharma, Pralay; Islam, Sk Saruk; Abu Imam Saadi, Sk Md; Mandal, Santi M. title: A brief survey of COVID-19 and role of photochemicals to prevent the infection date: 2021-11-06 journal: Journal of the Indian Chemical Society DOI: 10.1016/j.jics.2021.100244 sha: db6e7579febba1dd7aaaccce77a2be2e5f6f8f02 doc_id: 751592 cord_uid: f4gh2mjz Background The recent pandemic by COVID-19 is a global threat to human health. The disease is caused by SARS-CoV-2 and the infection rate is increased more quickly than MERS and SARS as their rapid adaptation to varied climatic conditions through rapid mutations. It becomes more severe due to the lack of proper therapeutic drugs, insufficient diagnostic tool, scarcity of appropriate drug, life supporting medical facility and mostly lack of awareness. Therefore, preventive measure is one of the important strategies to control. In this context, herbal medicinal plants received a noticeable attention to treat COVID-19 in Indian subcontinent. Here, 44 Indian traditional plants have been discussed with their novel phytochemicals that prevent the novel corona virus. The basic of SARS-CoV-2, their common way of transmission including their effect on immune and nervous system have been discussed. We have analysed their mechanism of action against COVID-19 following in-silico analysis. Their probable mechanism and therapeutic approaches behind the activity of phytochemicals to stimulate immune response as well as inhibition of viral multiplication discussed rationally. Thus, mixtures of active secondary metabolites/phytochemicals are the only choice to prevent the disease in countries where vaccination will take long time due to overcrowded population density. for antiviral activity against seven viruses [62] . Twelve extracts were found to have antiviral (Table-360 2). (3), and threo-1-[1-oxo-9(3,4-methylenedioxyphenyl)-8,9-dihydroxy-2E-nonenyl]-piperidine (4) were isolated, besides two new natural products 3b,4a-dihydroxy-2piperidinone (5), 5,6-dihydro-2(1H)-pyridinone (6) (Fig. 1) . Compounds 2-6, together with the isolates previously obtained with a large amount from P. longum involving piperine (7),3,7 1-[1-oxo-5(3-methoxyl-4-hydroxyphenyl)-2E-pentenyl]-piperidine (8),6,10 guineesine (9),3,5 (2E,4E)-N-isobutyleicosa-2,4-dienamide (10) SAC) and diallyl trisulfide (DTS) 4′-trihydroxy-6,8-dimethoxyflavone, βsitosterol, betulin, 4-hydroxybenzoic acid, ethyl gallate, methoxyflavones, apigenin oleic, linoleic, linolenic and stearic acids. flavonoids, iso vitexine and vitexine-2"-O-beta -D-glucopyrunoside 20 Daucus carota p-hydroxybenzoic acid; caffeic acid; chlorogenic acid; and the anthocyanins. phenolics, carotenoids, polyacetylenes, and ascorbic acid 21 Moringa sp Phenolic acids, flavonoids, isothiocyanates, tannins and saponins, N, α-Lrhamnopyranosylvincosamide, 4-(α-L-rhamnopyranosyloxy) phenyl acetonitrile (niazirin), pyrrolemarumine 4′′-O-α-Lrhamnopyranoside, 4′-hydroxy phenylethanamide-α Lrhamnopyranoside (marumoside A) and its 3-O-β-Dglucopyranosyl-derivative (marumoside B) and methyl 4-(α-L-rhamnopyranosyloxy)-benzylcarbamate, 4-O-(α-Lacetylrhamnopyranosyloxy)-benzyl glucosinolates, deoxy-niazimicine 5280805) 39.8640 K261, G265, R490, R498, G527, N529, T262, V263, D264, F528, D530, W531 -118.61 Jatropha curcas 10 Human Furin:A (PDB:4RYD) 5281672) 13.5507 A412, T413, R512, T514, H537, H422 Jatropha curcas 11 Human Furin:A (PDB:4RYD) 5281708) 16.2532 A292, S368, H194, S253, W254, G255, D258 5280443) 20.6339 N310, N529, A532, G307 5280441) 37.1296 G255, N295, W254 Jatropha curcas 14 Human Furin:A (PDB:4RYD) 5280794) 57.5356 S311, I312, G307, N310, N529, W531 Jatropha curcas 15 Human Furin:A (PDB:4RYD) Beta-sitosterol (PubChem CID: 222284) 61.7182 W254, G255, E257, D258 Human Furin:A Quercetin 19.2953 S253, W254, D258, S293, -92.62 Jatropha curcas (PDB:4RYD) Human Furin:A (PDB:4RYD) Benzoic Acid (PubChem CID: 243) 5.1257 S311, I312, Q488, G307 Jatropha curcas 19 Human Furin:A (PDB:4RYD) Salicylic Acid (PubChem CID: 338) 5.9864 R197, R193, H364, H194 Jatropha curcas 20 Human Furin:A (PDB:4RYD) CID: 638024) 22.3105 H405, Q129, D131, N133 9974595) 25.6848 G255, D258, H364, H194, W254 1107) 46.5331 R391, V444, A445, V278, S279, T389 128229) 147.4117 H364, R193, R197, N295, Q346, Q350, T365, G366, W328 (PDB:4RYD) Triterpenoid (PubChem CID: 451674) 83.8831 R268, Q488, P266, E271, G307, S311, Y313, R490, W531, A532 -102.97 Glycyrrhiza glabra 27 Human Furin:A (PDB:4RYD) 5320618) 23.9457 D153, D154, N295, H194, S253 636403) 94.1615 R498, D264, G307, N310, Q488, V263, G265, P266, D526, W531 -106.93 Glycyrrhiza glabra 29 Human Furin:A (PDB:4RYD) 4-hydroxybenzoic Acid (PubChem CID: 6.1428 N295, S368, S253, W254, G255 -68.95 Oxalis corniculata 30 Human Furin:A (PDB:4RYD) Caffeic Acid Daucus carota 31 Human Furin:A (PDB:4RYD) Chlorogenic Acid (PubChem CID: 1794427) 24.4496 D264, G265, P266, E271, N310, Q488 Ascorbic Acid (PubChem CID: 54670067) 10.0206 S253, W254, G255, A292 PDB:4RYD) Ibuprofen (PubChem CID: 3672) 13.1030 R197, H364, T365, D191 PDB:4RYD) Beta-pinene (PubChem CID: 14896) 42.4570 K402, H405 Cinnamomum tamala 36 Human Furin:A (PDB:4RYD) Cinnamomum tamala 37 Human Furin:A (PDB:4RYD) CID: 442793) 13.5860 R490, R498, G527, N529, A532, V263, W531 -81.42 Zingiber officinale 39 Human Furin:A (PDB:4RYD) Citric Acid (PubChem CID: 311) 10.4725 R193, R197, H364, H194, T365 -81.18 Zingiber officinale 41 Human Furin:A (PDB:4RYD) 63 Zingiber officinale 42 Human Furin:A Oxalic Acid 3.4268 R193, R197, H364 4RYD) Succinic Acid (PubChem CID: 1110) 5.5864 R197, R193, H364, T365 4RYD) Tartaric Acid CID: 8103) 4.2305 S302, L515, A517, H422 Terpinen-4-ol (PubChem CID: 11230) 11.9362 N310, A532, G307 PubChem CID: 17100) 10.3419 R512, H537, A412, T413, T511 -60.28 Glycyrrhiza glabra 50 Human Furin:A (PDB:4RYD) Propionic Acid (PubChem CID: 1032) 2.2108 S293 76 Glycyrrhiza glabra 52 Human Furin:A (PDB:4RYD) 2, 3 butanediol (PubChem CID: 262) 2.2703 W254, A292, G255 -54.22 Glycyrrhiza glabra (PDB:4RYD) Furfuryl formate 88 Glycyrrhiza glabra 55 Human Furin:A (PDB:4RYD) Piperonal (PubChem CID: 8438) 14.3266 D258, N295, S253, W254 Human Furin:A (PDB:4RYD) 2, 3, 5 Trimethyl pyrazine (PubChem CID: 26808) 6.2161 W254, A292, G255 Human Furin:A (PDB:4RYD) Methyl piperate (PubChem CID: 9921021) 17.1656 G265, I312, Q488, G307, S311 44453654) 25.5185 S311, Q488, R498, E271 PubChem CID: 44454018) 26.7749 H395, R483, T573, A436, N440, W441 5320621) 5.1772 G126, H405, V127, Q129, D131