key: cord-0751318-fchg7o0q
authors: Heldman, Madeleine R.; Kates, Olivia S.; Fisher, Cynthia E.; Limaye, Ajit P.
title: Immunosuppression in solid organ transplant recipients with Covid‐19: More data, but still complicated
date: 2021-07-29
journal: Transpl Infect Dis
DOI: 10.1111/tid.13650
sha: cb36ee61c371fc4969cbd6c13a2c1320df88566c
doc_id: 751318
cord_uid: fchg7o0q

“Outcomes of COVID‐19 in solid organ transplant (SOT) recipients: a matched cohort study” by Pereira et al found similar 28 day mortality among hospitalized SOT recipients and comorbidity matched controls, shedding light on the relationship between immunosuppression and Covid‐19 outcomes.

When Covid-19 emerged as a global pandemic, there were concerns that immunosuppression would predispose solid organ transplant (SOT) recipients and other immunocompromised populations to more severe or fatal disease than the general population. These concerns stemmed from past experience with other respiratory viruses and from early reports of high mortality in SOT recipients. 1 Advanced age and comorbidities that are prevalent among SOT recipients have been consistently shown to be associated with mortality in Covid-19, 2 there was no significant difference in mortality between SOT and non-SOT patients. 10 recipients and comorbidity matched cohorts will be necessary to fully understand the relationship between immunosuppression and outcomes during future pandemics.

Covid-19, immunosuppression, solid organ transplantation

Impact of COVID-19 in solid organ transplant recipients

COVID-19 in solid organ transplant: a multi-center cohort study

Outcomes of Coronavirus Infectious Disease -19 (COVID-19) in Solid Organ Transplant Recipients: a Propensity Matched Analysis of a Large Research Network

Outcomes following SARS-CoV-2 infection in liver transplant recipients: an international registry study

Epidemiological pattern, incidence and outcomes of COVID-19 in liver transplant patients

Outcomes of critically Ill solid organ transplant patients with COVID-19 in the United States

COVID-19 in solid organ transplantation: a matched retrospective cohort study and evaluation of immunosuppression management

A retrospective matched cohort single-center study evaluating outcomes of COVID-19 and the impact of immunomodulation on COVID-19-related cytokine release syndrome in solid organ transplant recipients

clinical characteristics, hospitalization, and mortality rates of Coronavirus Disease 2019 among liver transplant patients in the United States: A Multicenter Research Network Study

Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: acute phase cytokines and outcomes in a prospective, matched cohort study

Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review

Impact of SARS-CoV-2 viral load on risk of intubation and mortality among hospitalized patients with coronavirus disease 2019

Symptomatic respiratory virus infection and chronic lung allograft dysfunction

Antibody response to 2-dose SARS-CoV-2 mRNA vaccine series in solid organ transplant recipients

COVID-19 infection in solid organ transplant recipients after SARS-CoV-2 vaccination

The authors have no relevant conflicts of interests to disclose.

This work was supported by the National Institute of Allergy and Infectious Diseases (T32AI118690 to MRH and OSK) and the National Heart, Lung, and Blood Institute (HL143050 to CEF) of the National Institutes of Health. The content is solely the responsibility