key: cord-0750533-fv355ywl authors: Singh, Anurag Kumar; Bhushan, Bharat; Maurya, Anand; Mishra, Gaurav; Singh, Santosh Kumar; Awasthi, Rajendra title: Novel coronavirus disease 2019 (COVID‐19) and neurodegenerative disorders date: 2020-05-26 journal: Dermatol Ther DOI: 10.1111/dth.13591 sha: b8f37c5faba86cac9cf3a50032292bb12c488716 doc_id: 750533 cord_uid: fv355ywl During the last few months, the whole humanity is experiencing largest and most severe sudden influx of COVID‐19 outbreak caused by the novel coronavirus (CoV) originated from Wuhan, China. According to the WHO reports, total 3 862 676 positive cases and 265 961 deaths have been recorded worldwide due to COVID‐19 infection as of May 9, 2020. CoVs are a large family of viruses (enveloped, single‐stranded RNA viruses), which includes severe acute respiratory syndrome coronavirus (SARS‐CoV) and Middle East respiratory syndrome‐related coronavirus (MERS‐CoV). New SARS CoV2 is the members of Betacoronavirus genus. These viruses cause infections in bats, camels and humans, and a few other associated species. Despite many neurologic complications associated with SARS‐CoV‐2 infection, it is still unclear whether these symptoms results from direct neural injury or due to some other reason. Currently, it appears that most of the neurological symptoms of COVID‐19 are nonspecific and secondary to the systemic illness. A single case of acute hemorrhagic necrotizing encephalopathy has been reported. SARS‐CoV‐2 associated Guillain‐Barré syndrome is an atypical case. Till today, no convincing evidence is available to confirm that the SARS‐CoV‐2 virus directly affects nerves system in humans. However, postinfection surveillance will be necessary to identify the possible post‐COVID‐19 neurologic syndromes. During the last few months, the whole humanity is experiencing the largest and most severe sudden influx of COVID-19 outbreak caused by the novel coronavirus (CoV) originated from Wuhan city. Coronavirus was officially announced as the causative pathogen of COVID-19 by the Chinese Center for Disease Control and Prevention on January 8, 2020. The World Health Organization announced coronavirus outbreak as a public health emergency of international concern. It started to expect disturbing extents over the globe as forewarned by the World Health Organization (WHO) reports associated Guillain-Barré syndrome is an atypical case. Till today, no convincing evidence is available to confirm that the SARS-CoV-2 virus directly affects the CNS or PNS in humans. However, postinfection surveillance will be necessary to identify the possible post-COVID-19 neurologic syndromes. WHO Report on Coronavirus Disease (COVID-19) Pandemic The novel coronavirus (SARS-CoV-2) is a one health issue Coronavirus envelope protein: current knowledge Mapping of the coronavirus membrane protein domains involved in interaction with the spike protein Membrane binding proteins of coronaviruses A conserved domain in the coronavirus membrane protein tail is important for virus assembly Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China A pneumonia outbreak associated with a new coronavirus of probable bat origin Nervous system involvement after infection with COVID-19 and other coronaviruses COVID-19: consider cytokine storm syndromes and immunosuppression COVID-19-associated acute hemorrhagic necrotizing encephalopathy: CT and MRI features Guillain-Barré syndrome associated with SARS-CoV-2 infection: causality or coincidence? Neurological implications of COVID-19 infections. Neurocrit Care Neurology in the time of COVID-19 Clinical characteristics of coronavirus disease 2019 in China Neurologic manifestations of hospitalized patients with coronavirus disease Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients Acute Cerebrovascular Disease Following COVID-19: A Single Center How to cite this article The authors declare no potential conflict of interest. https://orcid.org/0000-0003-2125-810XRajendra Awasthi https://orcid.org/0000-0002-1286-1874