key: cord-0749748-blz6hfno
authors: Millones‐Gómez, Pablo Alejandro
title: Mouthwashes in COVID‐19: Benefit or harm to the oral microbiome?
date: 2021-08-03
journal: Oral Dis
DOI: 10.1111/odi.13975
sha: 9317c247578254aa4488ff7eabc9ef6b57a29e60
doc_id: 749748
cord_uid: blz6hfno

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The human oral microbiome (HOM) is the second largest and most complex microbial community after that of the gut in the human body (Caselli et al., 2018) . Dysbiosis of the HOM is often associated with various local and systemic disease conditions (Baghbani et al., 2020) . The microbial component of a eubiotic HOM can inhibit pathogen colonization by competitive exclusion and/or by enhancing the immune response (Soffritti et al., 2021) .

Respiratory viruses, such as SARS-CoV-2 spread by aerosol transmission encounter the oral microbiota, are modulated in their ability to establish infection and are capable of inducing changes in the resident microbiota (Soffritti et al., 2021) . Faced with the potential risk of virus transmission in dental offices international health authorities have suggested the use of antiseptic mouth rinses as an infection control measure prior to dental procedures (Volgenantet al., 2021) . However, there are currently few robust studies on the effect of mouth rinses on SARS-CoV-2 viral load.

The first report on the efficacy of mouth rinses in reducing SARS-CoV-2 viral load in saliva was published in Korea (Yoon et al., 2020) .

Subsequently, (Martínez Lamas et al., 2020) in a case series of four patients suggested that mouthwash with iodopovidone could reduce SARS-CoV-2 viral load in saliva in patients with higher viral loads. Despite these results, further controlled clinical studies with larger populations confirming its efficacy are still recommended (Eduardo et al., 2021) . Although recent findings have been able to demonstrate bacterial taxonomic changes at both the individual and population level, only the tip of an iceberg has been revealed regarding the complexity of host-microbiota interactions (Freire et al., 2021) .

Thus, so far, there are no studies available that measure the impact of the use of mouthwashes on oral microbiomes. The use of these antiseptics for antiviral purposes that have not been reliably demonstrated could be turning them into disruptors of the oral microbiological balance, therefore, they could not be recommended without knowing their real implications. Likewise, if studies in these areas of research are intensified, it will probably be possible to implement the signatures of the host microbiome as a clinical timeline capable of indicating with certainty not only a desired therapeutic effect but also a harmless one for the microbial balance. 

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Reducing healthcare-associated infections incidence by a probiotic-based sanitation system: A multicentre, prospective, intervention study

Salivary SARS-CoV-2 load reduction with mouthwash use: A randomized pilot clinical trial

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Is LETTER TO THE EDITOR povidone iodine mouthwash effective against SARS-CoV-2? First in vivo tests

Oral microbiome dysbiosis is associated with symptoms severity and local immune/inflammatory response in COVID-19 patients: A cross-sectional study

Infection control in dental health care during and after the SARS-CoV-2 outbreak

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