key: cord-0747339-opjsk7lp authors: Yamakawa, Makoto; Nakahara, Keiichi; Nakanishi, Toshihito; Nomura, Toshiya; Ueda, Mitsuharu title: Miller Fisher Syndrome Following Vaccination against SARS-CoV-2 date: 2022-04-01 journal: Intern Med DOI: 10.2169/internalmedicine.8851-21 sha: a8d01a9c7be25706799eca86158e55c1ff628960 doc_id: 747339 cord_uid: opjsk7lp After BNT162b2 messenger ribonucleic acid (mRNA) coronavirus disease 2019 (COVID-19) vaccination, a 30-year-old man developed bilateral lateral gaze palsy, diplopia, absent tendon reflexes, and ataxic gait. Serum anti-GQ1b and anti-GT1a immunoglobulin G (IgG) antibodies were strongly positive. Based on those findings, he was diagnosed with Miller Fisher syndrome (MFS). Intravenous immunoglobulin therapy was administered, and his symptoms fully recovered within approximately 3 months. To the best of our knowledge, this is the first report to describe the development of MFS after COVID-19 mRNA vaccination. The coronavirus disease 2019 (COVID-19) pandemic has necessitated large-scale global vaccination campaigns to control the spread of this infection under emergency use authorization. Although the the risks and benefits of vaccination should be considered for the individual, we still do not fully understand the risk of neurologic disorders after COVID-19 vaccine administration. We herein report the case of a patient who developed Miller Fisher syndrome (MFS) after BNT162b2 messenger ribonucleic acid (mRNA) COVID-19 vaccination. To the best of our knowledge, this is the first report to describe the development of MFS after mRNA COVID-19 vaccination. A 30-year-old healthy Japanese man received a second dose of tozinameran (BNT162b2 mRNA COVID-19 vaccine). He reported fever and cough during the first week after the vaccination. On day 7 post-vaccination, he experienced diplopia, dizziness, and difficulty walking. The patient was admitted to our hospital on day 8. A neurological ex-amination revealed multidirectional diplopia, while his eye movement was full and smooth and tandem gait was impossible. A laboratory analysis revealed normal findings. All other clinical findings associated with the cranial, motor, and sensory nerves, as well as reflexes, were normal. Cerebrospinal fluid (CSF) and nerve conduction studies were normal on admission. Respiratory function tests, chest radiography, and contrast-enhanced magnetic resonance imaging of the brain and spine showed normal findings. On day 11, the patient developed bilateral lateral gaze palsy and ataxic gait ( Figure) . The biceps and patella tendon reflexes were absent, whereas the Achilles reflex was present. Serum anti-GQ1b and anti-GT1a immunoglobulin G (IgG) antibodies were strongly positive. Based on those findings, he was diagnosed with MFS. On day 12, intravenous immunoglobulin (IVIg) therapy (400 mg/kg/day for 5 days) was administered. His symptoms fully recovered by day 105. (6), with a higher incidence in Asian countries than in Western countries (7) . It is usually preceded by viral or diarrhoeal illness and is strongly associated with serum anti-GQ1b IgG antibodies (8) . The prog-nosis of MFS is usually good, with a median time to full recovery of 1 month for ataxia and 3 months for ophthalmoplegia (7) . The present patient exhibited the clinical triad of MFS accompanied with serum anti-GQ1b IgG antibody positivity. He was treated with IVIg therapy and fully recovered in approximately 3 months. A score of 5 on the Naranjo adverse drug reaction probability scale (9) suggested an association between the mRNA COVID-19 vaccination and MFS, which was supported by the absence of any other trigger of MFS. Furthermore, the interval between the vaccination and the onset of neurological symptoms was 7 days. Most cases of GBS after mRNA COVID-19 vaccination, as well as that of GBS after influenza vaccination, occurred within 2 weeks of vaccination (10) (Table) . In several reports, mRNA COVID-19 vaccination was not associated with GBS (4, 11, 12) . Whereas, adverse events were more commonly reported among the mRNA COVID-19 vaccination group (13) . The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is provided in the mRNA vaccine, binds to sialic acids linked to host cell surface gangliosides (14) . This affinity of spike proteins for gangliosides may lead to the development of GBS. Although it remains unclear how mRNA COVID-19 vaccination induced MFS in this case, mRNA COVID-19 vaccination could be associated with MFS. In conclusion, mRNA COVID-19 vaccination may rarely induce MFS. Written informed consent was obtained by the patient for use and publication of the facial photographs. 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To view the details of this license We would like to thank Professor Susumu Kusunoki (Department of Neurology, Kinki University School of Medicine, Osaka) for measuring the anti-ganglioside antibodies and all members of the Department of Neurology at Kumamoto University Hospital for helping with the collection of clinical data.