key: cord-0747313-9rko3toz
authors: Baskaran, Krishoban; Cohen, Adrienne Wai Seung; Weerasinghe, Nethmi; Vilayur, Eswari
title: Report of two cases of minimal change disease following vaccination for COVID ‐19
date: 2021-11-15
journal: Nephrology (Carlton)
DOI: 10.1111/nep.13995
sha: 29afb3878e62cb788bfdfe4a934e652a314be3cd
doc_id: 747313
cord_uid: 9rko3toz

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Minimal change disease (MCD) is a common cause of nephrotic syndrome in children and young adults with foot process effacement being the classical feature seen on electron microscopy. The exact mechanism for MCD is not well understood, though evidence suggests that systemic T cell dysfunction results in the production of a glomerular permeability factor. This induces foot process effacement resulting in severe alteration of the glomerular filtration system and resulting marked proteinuria. 1 MCD following vaccination has been reported in literature, occurring between 4 days and several weeks later. 1,2 Both SARS-CoV-2 mRNA and ChAdOx1 nCoV-19 vaccines have been associated with MCD, with most cases arising within the first week. 2 We report two cases of de novo MCD with nephrotic syndrome following ChAdOx1 nCoV-19 and BNT162b2 mRNA COVID Vaccines.

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