key: cord-0740310-fphpn5we authors: Hamadeh, Anas; Aldujeli, Ali; Briedis, Kasparas; Tecson, Kristen M.; Sánchez, Jorge Sanz; Al dujeili, Montazar; Al-Obeidi, Ammar; Luís, Jose; Žaliūnas, Remigijus; Stoler, Robert C.; McCullough, Peter A. title: Characteristics and Outcomes in Patients Presenting with COVID-19 and ST-Segment Elevation Myocardial Infarction date: 2020-07-03 journal: Am J Cardiol DOI: 10.1016/j.amjcard.2020.06.063 sha: 92205b253d59235effe41e15f028c7109fe813dd doc_id: 740310 cord_uid: fphpn5we There is limited information regarding clinical characteristics and outcomes of patients with SARS-CoV-2 (COVID-19) disease presenting with ST-segment elevation myocardial infarction (STEMI). In this multicenter retrospective study, we reviewed charts of patients admitted with symptomatic COVID-19 infection and STEMI to a total of 4 hospitals spanning Italy, Lithuania, Spain and Iraq from February 1, 2020 to April 15, 2020. A total of 78 patients were included in this study, 49 (63%) of whom were men, with a median age of 65 [58, 71] years, and high comorbidity burden. During hospitalization, 8 (10%) developed acute respiratory distress syndrome, and 14 (18%) required mechanical ventilation. 19 (24%) patients were treated with primary PCI and 59 (76%) were treated with fibrinolytic therapy. 13 (17%) patients required cardiac resuscitation, and 9 (11%) died. For the 19 patients treated with primary PCI, 8 (42%) required intubation and 8 (42%) required cardiac resuscitation; stent thrombosis occurred in 4 patients (21%). A total of 5 patients (26%) died during hospitalization. 50 (85%) of the 59 patients initially treated with fibrinolytic therapy had successful fibrinolysis. The median time to reperfusion was 27 minutes [20, 34]. Hemorrhagic stroke occurred in 5 patients (9%). Six patients (10%) required invasive mechanical ventilation; 5 (9%) required cardiac resuscitation, and 4 (7%) died. In conclusion, this is the largest case series to-date of COVID-19 positive patients presenting with STEMI and spans 4 countries. We found a high rate of stent thrombosis, indicating a possible need to adapt STEMI management for COVID-19 patients. As of May 20, 2020, the total number of confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; COVID-19) infections worldwide had surpassed 4.5 million cases and the associated reported deaths neared 325,000 [1] . Systemic viral infections have been associated with acute myocardial infarction and inflammation [2, 3] , and may indeed be a pathophysiologic trigger for plaque rupture and thrombosis. Despite the burgeoning literature regarding the general COVID-19 positive population, little is known about the specific clinical characteristics and outcomes of patients with active COVID-19 infection presenting with STsegment Elevation myocardial infarction (STEMI). In fact, data thus far have been mostly limited to a small case series of 18 patients in New York City with a reported mortality of 72% [4] , and another of 28 patients from northern Italy with a reported mortality of 39% [5] . This retrospective multicenter, medical chart review of consecutive patients hospitalized between February 1, 2020 and April 15, 2020 with COVID-19 and STEMI was conducted at a total of 4 hospitals in Lithuania, Italy, Spain and Iraq. Patients were confirmed as having COVID-19 infection via positive result on polymerase chain reaction testing of a nasopharyngeal sample. COVID negative patients who treated for STEMI in these centers were excluded from this study. Timing of COVID-19 PCR results as it relates to time of PCI were not available. Data collection was performed by medical doctors at the hospitals where these patients were admitted by reviewing the patients' electronic medical records as well as their paper charts. A 10% random sample from the data set was verified by the same physicians at the collecting sites after data collection was complete to ensure accuracy of the collected information. Data collected 4 included patient demographics, comorbidities, existing medications, laboratory tests, electrocardiogram (ECG) results, echocardiography results, diagnosis during the hospital course, inpatient medication, treatments (fibrinolytic therapy, PCI, vasopressor use, invasive mechanical ventilation), and outcomes (duration of hospitalization, revascularization success, in-hospital reinfarction, and mortality). Home medications were reported based on admission medication reconciliation performed by the admitting physician. Coronary artery disease included prior myocardial infection (MI), coronary artery bypass surgery, prior PCI, angina, and/or abnormal cardiac stress testing. The choice of initial reperfusion strategy of either fibrinolytic therapy or primary PCI was at the discretion of the treating interventional cardiologist at each site according to institutional guidelines, since international management guidelines do not exist for these patients. Generally, patients presenting with COVID-19 and STEMI in Lithuania, Italy, and Iraq without hemodynamic instability or high-risk features, were treated with fibrinolytic therapy. If successful, patients were discharged home and brought back for invasive revascularization after testing negative for COVID-19 at least 14 days after diagnosis. In Spain, most patients with suspected or confirmed COVID-19 who presented with STEMI were treated via primary PCI. Successful fibrinolysis was defined as ST-segment resolution by >50% within 60-90 min of fibrinolytic administration with absence of chest pain and signs of hemodynamic or electrical instability. Thrombolysis in MI (TIMI) flow grade was assessed angiographically by the performing physician [6] . During PCI, door-to-wire crossing time was recorded as a surrogate for reperfusion in accordance with the 2017 European Society of Cardiology guidelines for management of acute MI (AMI) in patients presenting with ST-segment elevation [7] . STEMI and stent thrombosis were defined according to the fourth universal definition of MI [8] . Post fibrinolysis re-infarction was defined as the presence of any two of the following: 1) new ischemic ST segment deviation on ECG; 2) new signs or symptoms suggestive of ongoing ischemia; 3) an increase in cardiac troponin in accordance with the fourth universal definition of MI for post PCI myocardial infarction [8] . COVID-19 presentation was classified according the WHO definitions of clinical syndromes associated with COVID-19 [9] . Chronic kidney disease staging was performed according to the National Kidney Foundation Kidney Disease Outcomes Quality Initiative clinical practice guidelines for chronic kidney disease [10]. Dyslipidemia was defined as an LDL > 70 mg/dL, HDL < 50 mg/dL in women and < 40 mg/dL in men. Continuous variables are presented as median [25 th percentile, 75 th percentile]. Categorical variables are presented as frequency and percentage. As this analysis utilized deidentified data, it was exempt from Institutional Review Board review. A total of 78 patients were included in this review, a majority of whom were men, with a median age of 65 [58, 71] years as shown in Table 1 . Patients carried a high comorbidity load; most (43, 55%) had at least 4 comorbidities. The most common comorbidities were dyslipidemia (72, 92%), hypertension (57, 73%), smoking (41, 53%), and diabetes mellitus (21, 27%). During hospitalization, 34 patients (44%) had mild pneumonia, 2 (3%) had severe pneumonia, 8 (10%) developed acute respiratory distress syndrome, 5 (6%) developed septic shock, and a total of 14 (18%) required mechanical ventilation. Median pain to reperfusion time was 12.6 [8, 15] hours. 19 (24%) patients were treated with primary PCI and 59 (76%) were treated with fibrinolytic therapy as the initial reperfusion strategy. A total of 13 patients (17%) required cardiac resuscitation, 7 (9%) re-infarcted during their hospitalization, and 9 (12%) died. 6 For the 19 patients treated with primary PCI, 1 patient (5%) had no evidence of coronary artery obstruction and was diagnosed with myocarditis. The median door-to-wire time was 128 [90, 210] minutes. The most common culprit artery was the left anterior descending artery (8 patients; 44%). All patients received a drug eluting stent (DES). 8 patients (42%) [40%, 48%]. Hemorrhagic stroke occurred in 5 patients (9%). 6 patients (10%) required invasive mechanical ventilation; 5 (9%) required cardiac resuscitation, and 4 (7%) died (Figure 2 ). Of the 9 patients who failed fibrinolytic therapy; 1 patient (11%) died prior to PCI and the remaining 8 (89%) underwent PCI; 2 patients (25%) died following PCI. Of these 9 patients, 7 (78%) had obstructive coronary artery disease, and underwent PCI with a DES; 1 patient (11%) was diagnosed with myocarditis. Of all 78 STEMI patients positive for COVID-19 infection, 14 (18%) required invasive mechanical ventilation. Their median age was 68 [60, 74] years, and 9 (64%) were men. The most common comorbidities were history of ischemic heart disease (13, 93%) dyslipidemia (13, 93%) , hypertension (11, 79%) , and smoking (9, 64%). Eight (57%) of the patients who required mechanical ventilation underwent primary PCI, and 6 (43%) were treated with fibrinolytic therapy as the initial reperfusion strategy. Two (14%) patients had a hemorrhagic stroke, 11 (79%) required cardiac resuscitation, and 7 (50%) died. The median length of stay was 14 [9, 15] days. The optimal management strategy for patients with STEMI and concurrent COVID-19 may present a greater challenge than for pre-pandemic STEMI patients. The utilization of fibrinolytic therapy has gained attention recently as a viable option for stable patients presenting with COVID-19 disease and STEMI [11] . Experts treating STEMI patients with COVID-19 in China recommend fibrinolytic therapy over primary percutaneous coronary intervention (PCI) in stable patients who present within 12 hours of symptom onset and do not have a contraindication for fibrinolytics [12] . However, many questions remain unanswered about this select population. Hence, this study fills a critical knowledge gap by describing the baseline characteristics and comorbidities, presenting laboratory tests, clinical course, revascularization strategies, and outcomes of patients admitted with COVID-19 disease and STEMI. To our knowledge, this study size of 78 patients represents the largest case series of patients presenting with active COVID-19 and STEMI. The patients in this study were of advanced age and highly comorbid. All patients presented with at least 1 comorbidity, nearly all (75, 96%) had 2 or more comorbidities, and 62 (80%) had 3 or more comorbidities. The overall mortality in this study was 12%, which is lower than what was reported in a smaller case series of 19 patients presenting with COVID-19 and STEMI in New York [4] , and another case series of 28 patients in Italy [5] . However, this study reported mortality rates for patients with definite outcomes (discharge or death), and longer-term studies may report different mortality rates. Our 8 observed mortality rate among mechanically ventilated patients is within range of previously reported rates in critically ill COVID-19 patients in China and the United States [14, 15] . STEMI is a highly morbid condition, and mortality in this disease is influenced by a plethora of patient characteristics. For example, female gender, old age, anterior MI, and prior coronary artery disease are associated with worse outcomes in these patients [16] . Influenza and other viral respiratory infections have been reported to act as triggers for AMI [2] , and influenza may modestly increase the risk for STEMI [3] . Hence, it is plausible that the COVID-19 infection and systemic inflammatory response may have been a trigger for the STEMI event in many cases. The standard of care for patients without COVID-19 presenting with STEMI is invasive revascularization within 90 minutes of hospital presentation. Fibrinolytic therapy is recommended if there is an expected delay of more than 90 minutes to invasive revascularization [7, 17] . However, in the ongoing COVID-19 pandemic, multiple expert statements from the United States and China have recommended initiating fibrinolytic therapy as a first line therapy for these stable patients without high-risk features as an effort to mitigate the spread of the disease [11, 12, 13] . Alarmingly, patients in this study who were treated with PCI had a 21% rate of stent thrombosis, which is much higher than previously reported rates of early stent thrombosis of ~1% [18] . Further, it has been reported that patients in the intensive care unit for COVID-19 have a remarkably high incidence of thrombotic complications (approximately 31%) [19] , and that anticoagulation may improve outcomes in such patients who have elevated Ddimer [20] . These COVID-19-specific observations could explain why patients in our study had a higher-than-expected rate of stent thrombosis. Therefore, it is important to continue to monitor 9 thrombotic events in this population with larger studies in order to guide timing and strategies of invasive revascularization. This study has all the limitations of retrospective studies of prospectively collected data. First, the patient populations, including COVID-19 symptom presentation, were not homogenous across countries. Second, each medical center followed their own institutional guidelines for managing patients presenting with COVID-19 and STEMI. This precluded statistical testing between primary PCI and thrombolysis strategies and may limit the generalizability of our findings. Third, due to small event counts, adjusted analyses were not possible. Fourth, there were missing data points for some procedural characteristics and outcomes. Lastly and most importantly, we did not have a concurrent control group of patients with STEMI at the same centers without concurrent COVID-19 infection. In conclusion, this is the largest case series to-date of COVID-19 positive patients presenting with STEMI and spans 4 countries. We found a high rate of thrombotic complications and a very high mortality rate. Our results suggest a possible need to adapt STEMI management for patients with concurrent COVID-19 infection. D: Supervision, Conceptualization, Data curation, Methodology, Writing-Original Draft preparation, Writing-Reviewing and Editing Sc: Supervision, Conceptualization, Investigation, Validation, Writing-Reviewing and Editing Sc: Conceptualization, Investigation-Data collection, Validation, Writing-Reviewing and Editing Tecson Ph.D: Formal Analysis, Writing-Reviewing and Editing, Visualization, Funding acquisition D: Investigation-Data collection, Validation, Writing-Reviewing and Editing Investigation-Data collection, Validation, Writing-Reviewing and Editing Investigation-Data collection, Validation, Writing-Reviewing and Editing D: Investigation-Data collection, Validation, Writing-Reviewing and Editing Ph.D: Writing-Reviewing and Editing Robert C. Stoler M.D: Writing-Reviewing and Editing Writing-Reviewing and Editing. Acknowledgements: This work was funded, in part, by the Baylor Health Care System Foundation. 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