key: cord-0739834-0nx7nbxr
authors: Gohil, Jaypalsinh; Gowda, Arun; George, Tobin; Easwer, H. V.; George, Alexander; Nair, Prakash
title: Pituitary apoplexy and panhypopituitarism following acute leptospirosis
date: 2021-05-21
journal: Pituitary
DOI: 10.1007/s11102-021-01156-1
sha: 09bbdbf060e2bfed56aaf856fee8df3177a51a20
doc_id: 739834
cord_uid: 0nx7nbxr

Leptospirosis is a common tropical febrile illness which may manifest with the hepatorenal syndrome and systemic hemorrhagic manifestations. Pituitary apoplexy is a rare but life-threatening condition characterized by a hemorrhage within the pituitary gland or a pituitary adenoma. Apoplexy is very rarely associated with some inducing events such as infectious diseases such as dengue hemorrhagic fever, Hantaan virus, Puumala virus have also been reported to cause pituitary apoplexy. We present the first case of pituitary apoplexy in a patient who was being treated for leptospirosis and discuss the possible mechanisms of apoplexy in the scenario presented. We also review other reports of infectious causes that may result in pituitary apoplexy.

Pituitary apoplexy is a rare but life-threatening condition characterized by a hemorrhage within the pituitary gland or a pituitary adenoma. Infectious diseases such as dengue hemorrhagic fever, Hantaan virus, Puumala virus have been reported to rarely cause pituitary apoplexy. Leptospira Interrogans is the causative organism for leptospirosis, which is a common tropical febrile illness that may manifest with the hepatorenal syndrome and systemic hemorrhagic manifestations. We present the first case of pituitary apoplexy in a patient who was being treated for leptospirosis and discuss the possible mechanisms of apoplexy in the scenario presented. We also review other reports of acute pituitary apoplexy in the setting an acute infectious illness.

A 56-year-old male with a medical history of type 2 Diabetes Mellitus was admitted to a general hospital with fever, nausea, vomiting, and abdominal pain for 5 days duration. During hospital evaluation, mild hepatosplenomegaly was noted on abdominal ultrasound. His chest X-ray was unremarkable.Complete blood count (CBC) at the time of admission showed a total white blood cell count (WBC) of 11,700/microl with 90% neutrophils and 10% lymphocytes (shift to left). The erythrocyte sedimentation rate (ESR) was 62 mm/hr. The serum creatine at admission was 1.8 mg/dl and blood urea were 56 mg/dl. The platelet count was 245,000/microl. During the serological evaluation for the etiology of a febrile illness, leptospira ELISA IgM was found to be elevated. Serological investigations for other febrile illnesses including dengue, typhoid and paratyphoid were negative. A clinical diagnosis of leptospirosis with acute kidney injury was established and treatment with intravenous cefoperazone and sulbactam along with oral doxycycline was administered. Over the course of the next few days, he became afebrile and maintained adequate urine output, his WBC count decreased to 6300/microl and his serum creatinine decreased to 1.2 mg/dl. After 5 days of admission he developed sudden onset severe headache, with diplopia, and partial ptosis in the left eye. On neurological evaluation, the left pupil was dilated and non-reactive to light. Visual field examination revealed bitemporal hemianopsia. Cerebrospinal fluid (CSF) examination was non-meningitic (CSF Glucose 85 mg/dl, protein 78 mg/dl, cells-nil). Other blood investigations included WBC 6300/microl, platelets 400,000 /microl and ESR-103 mm/hr. His blood clotting time at this instance was 10 min while the bleeding time was 1 min. The estimated Prothrombin time was 13.5 Seconds (INR-1). An MRI of the brain showed a sellar mass with hemorrhagic component measuring 1.5 × 2 × 2.4 cm in size expanding the sella and extending into the suprasellar cistern. The mass showed T2W hyper intensity and TIW isointensity with hypo intense areas of "blooming" in SWI sequences, which suggested hemorrhage. Plain CT head also showed hemorrhage in the pituitary adenoma. There was Knosp grade 4 involvement of the left cavernous sinus with more than 180° encasement left Internal Carotid Artery (ICA) (Fig. 1) . The MRI was consistent with apoplexy in a pituitary adenoma. On evaluation of anterior pituitary function showed evidence of hypopituitarism [S Cortisol 0.41 microgm/dl, TSH 0.16 mIU/L, Prolactin 3.21 ng/ml (1:100 dilution)]. In view of hypocortisolism, replacement doses of glucocorticoids were initiated. His hospital course was complicated by an acute kidney injury from which he made full recovery. He was then referred to our hospital for further management of the pituitary apoplexy where he was seen two weeks after the occurrence of pituitary apoplexy. On examination, the left-sided third nerve palsy had improved. There was only partial left sided ptosis and a full range of extraocular movements were present in the left eye. Repeat visual field charting showed resolution of the prior bitemporal hemianopsia and a full visual field. The right eye examination was normal. Contrast enhanced CT scan of the head performed during this visit revealed that the adenoma has decreased in size, with resolution of the hemorrhage. We then decided to place the patient on imaging follow up. Two months later, he no longer had ptosis in the left eye, the extra ocular movements were normal, and he had no visual field defects. The MRI performed during this visit showed resolution of the hemorrhagic focus and regression of the pituitary adenoma with a residual 4 mm adenoma in the left side of the Sella adjacent to the left cavernous ICA (Fig. 2) . This residual lesion is being followed up with serial MRI images. He is still on replacement doses of corticosteroid and thyroid hormones and is being monitored for recovery of pituitary function.

Leptospirosis is a zoonotic infectious disease that results in hemorrhagic diathesis, liver dysfunction, and renal failure. The causative organic L. Interrogans is a motile spiralshaped, biflagellate that can burrow into the tissue. Rodents are the most important reservoir of the organism; however, various farm animals and wild animals may also harbor the disease. The organism is excreted in the urine of the infected host [1] . The incidence of leptospirosis in the Indian subcontinent spikes during and soon after the monsoon season, which leads to flooding of agricultural land. Human infection with Leptospira occurs through the skin, which may come in contact with water contaminated with animal urine. Drinking contaminated water may also result in infection through the mucosal surface [2] . In untreated cases, a spirochetemic phase is followed by an immune phase. During this phase of spirochetemia, organisms can be found in the blood, cerebral spinal fluid (CSF), aqueous humor, and most tissues [3] . A more severe manifestation of leptospirosis is the Weil's syndrome characterised by hepatorenal involvement, haemorrhage and septicaemic shock [4, 5] .

Studies from the subcontinent have also shown that jaundice was one of the most common symptoms of leptospirosis followed by oliguric renal failure. The diagnosis of this disease is based on assessment of clinical features and serological tests mainly the ELISA IgM estimation [3] . When leptospirosis involves the central nervous system it causes headache, nuchal rigidity, photophobia and altered sensorium in addition to other less common manifestations like seizures, delirium, encephalopathy and coma [6] . This case is unique in this regard as Leptospirosis associated with pituitary apoplexy has not yet reported.

Pituitary apoplexy is defined as clinical syndrome due to abrupt hemorrhagic and /or infarction of the pituitary gland, generally within a pituitary adenoma [7] The pituitary gland derives its blood supply from the loose capillary networks forming portal circulation supplied by superior and inferior hypophyseal arteries. A pituitary adenoma on the other hand derives its vascularity from direct arterial branches of the SHA or the IHA. This makes adenoma more susceptible to haemorrhage [7] . While uncommon, various other infections also have been reported to cause in pituitary apoplexy (Table 1) . These include apoplexy caused by viral infection including Puumala [8] , dengue [9] , Hanta virus [10] and recently Covid-19 [11] . Tuberculosis and fungal infection associated with apoplexy have also been reported and these cases are treated with antitubercular or antifungal medication after surgery.Possible causative mechanisms that result in pituitary apoplexy in this scenario include thrombocytopenia and coagulation disorder or an autoimmune response leading to hemorrhagic vasculopathy.

With the available clinical information, we can only speculate as to the physiological mechanism that led to pituitary apoplexy, but we review various mechanisms that may result in this phenomenon. One of the proposed mechanisms of haemorrhage in leptospirosis is vasculopathy which mostly involves the capillaries. The postulated mechanism of this vascular insult is non-inflammatory vasculopathy. Disruption of endothelial cell-cell junctions, cell retraction and the consequent opening of intercellular gaps have been demonstrated by VE-cadherin immunohistochemistry [12] . Disruptions in adherens junctions due to protein alterations in VE-cadherins, p120 catenin, alpha and beta catenins has also been demonstrated [13] . This mechanism of increased permeability through cell junctions explains the occurrence of pulmonary oedema and haemorrhage in leptospirosis. Another postulated mechanism of cell surface injury in leptospirosis is the deposition of leptospiral antigen on the host cell membrane [3] . Tunjungputri et al. while investigating platelet dysfunction in leptospirosis, reported that increased VWF-platelet binding resulted in the activation and clearance of platelets leading to an increased severity of bleeding manifestations. Finally, platelet dysfunction may also be a result of uraemia, which occurs in the setting of acute kidney injury. Therefore, unlike many other viral infections like DHF, platelet dysfunction rather that an absolute decrease in platelet counts plays a greater role [14] . Hemorrhagic manifestations include epistaxis, hemoptysis, hematemesis, melena, conjunctival suffusion, skin rashes and other bleeding diatheses. Autopsy studies in have shown evidence of widespread hemorrhagic changes seen in the kidneys, liver, lungs, skeletal and cardiac muscles, serous membranes like the pleura and peritoneum and subarachnoid space [15, 16] . Panidis et al. reported a case of leptospirosis causing hypogonadism and hypopituitarism, they proposed that this could be due to direct hypothalamic pituitary axis injury by the organism or may be secondary due to release of inflammatory substance [17] .

The haemorrhage that occurs within the adenoma also resolves over a period of time, some of the possible mechanisms is presence of inflammatory reaction surrounding hemorrhage which causes resorption of the blood products [18] .

The time for resolution of pituitary apoplexy ranges from 6 week to 3 month [19] . Jackson et al. described 40% reduction in size at end of 1 week and 67.6% reduction at end of 7 weeks [20] . In our case it showed near complete resolution at 1 month.

Leptospirosis is a common tropical febrile illness that may manifest with the hepatorenal syndrome and systemic hemorrhagic manifestations. Leptospirosis leads to a non-inflammatory vasculopathy affecting capillaries 

Leptospira" and leptospirosis

Leptospira and leptospirosis

Leptospirosis in humans

The pathologic anatomy and pathogenesis of fatal human leptospirosis (weil's disease)

Weil's disease (fulminating leptospirosis) complicating as acute respiratory distress syndrome

Uncommon manifestation of leptospirosis: a diagnostic challenge

Pituitary apoplexy

Hypophyseal hemorrhage and panhypopituitarism during puumala virus Infection: magnetic resonance imaging and detection of viral antigen in the hypophysis

Pituitary apoplexy secondary to thrombocytopenia due to dengue hemorrhagic fever: a case report and review of the literature

Pituitary apoplexy case caused by Hanta virus infection

Pituitary apoplexy associated with acute COVID-19 infection and pregnancy

Leptospirosis pulmonary haemorrhage syndrome is associated with linear deposition of immunoglobulin and complement on the alveolar surface

Leptospira interrogans causes quantitative and morphological disturbances in adherens junctions and other biological groups of proteins in human endothelial cells

Platelet dysfunction contributes to bleeding complications in patients with probable leptospirosis

Coagulation disorders in patients with severe leptospirosis are associated with severe bleeding and mortality

A study of sutopsy findings in cases of leptospirosis in a metropolitan city in India

Hypothalamic-pituitary deficiency after Weil's syndrome: a case report

Spontaneous disappearance of the pituitary macroadenoma after apoplexy: a case report and review of the literature

Spontaneous resolution of a non-functioning pituitary adenoma following an apoplexy

Rapid pituitary apoplexy regression: what is the time course of clot resolution

Intrasellar tuberculoma presenting as pituitary apoplexy

Pituitary tuberculosis presenting as pituitary apoplexy

Pituitary apoplexy due to mucormycosis infection in a patient with an ACTH producing pulmonary tumor

Dengue hemorrhagic fever: a rare cause of pituitary tumor hemorrhage and reversible vision loss

Association of dengue hemorrhagic fever with multiple risk factors for pituitary apoplexy

Dengue hemorrhagic fever: a rare cause of pituitary apoplexy

Pituitary aspergillosis presenting as macroadenoma: case report and review of literature

Pituitary macroadenoma apoplexy in a severe acute respiratory syndrome-coronavirus-2-positive testing: causal or casual?

Corticotroph adenoma and pituitary fungal infection: a rare association