key: cord-0739342-euxvc41x authors: Alwafi, Hassan; Naser, Abdallah Y; Qanash, Sultan; Brinji, Ahmad S; Ghazawi, Maher A; Alotaibi, Basil; Alghamdi, Ahmad; Alrhmani, Aisha; Fatehaldin, Reham; Alelyani, Ali; Basfar, Abdulrhman; AlBarakati, Abdulaziz; Alsharif, Ghaidaa F; Obaid, Elaf F; Shabrawishi, Mohammed title: Predictors of Length of Hospital Stay, Mortality, and Outcomes Among Hospitalised COVID-19 Patients in Saudi Arabia: A Cross-Sectional Study date: 2021-04-15 journal: J Multidiscip Healthc DOI: 10.2147/jmdh.s304788 sha: e9feacd3ecfe4f6f4031f1a91769bd058a1d5d51 doc_id: 739342 cord_uid: euxvc41x BACKGROUND: COVID-19 pandemic is a major strain on health and economic systems, with rapidly increasing demand for in patients’ facilities. Disease diagnosis and estimating patients at higher risk is important for the optimal management during the pandemic. This study aimed to identify the predictors of mortality and length of hospital stay in COVID-19 patients. METHODS: A retrospective cross-sectional study was conducted between March 2020 and August 2020 at Al-Noor Specialist Hospital in Mecca, Saudi Arabia. All patients who were admitted and had a confirmed COVID-19 diagnosis by a real-time polymerase chain reaction (PCR) were included in the study. Descriptive statistics were used to describe patients’ demographic characteristics, laboratory findings, and clinical outcomes. Multiple logistic/linear regression analysis was used to identify predictors of death and length of stay at the hospital. RESULTS: A total of 706 patients were hospitalised for COVID-19. The mean age was 48.0 years (SD: 15.6 years). More than half of the patients (68.5%; n= 292) were males. The median duration of stay at the hospital was 6.0 days (IQR: 300–10:00). The prevalence rate of venous thromboembolism (VTE) among the patients was 3.0% (n= 21). In the multivariate logistic regression analysis, age (AOR: 1.05; 1.02–1.09), patients with end-stage renal disease (AOR: 6.44; 2.20–18.87), low Oxygen saturation SPO2 (AOR: 9.92; 4.19–23.50), D.dimer >0.5 (AOR: 13.31; 5.45–32.49), ESR>10 mm/h (AOR: 4.08; 1.72–9.68), Ferritin>400mcg/L (AOR: 18.55; 6.89–49.96), and Procalcitonin>0.5ug/L (AOR: 8.23; 1.81– 37.40) were associated with a higher risk of death among patients with COVID-19. Patients with VTE (AOR: 12.86; 3.07– 53.92) were at higher risk of death due to COVID-19. CONCLUSION: Hospitalised COVID-19 patients have multiple negative consequences in terms of their laboratory findings, signs and symptoms. Age and end-stage renal diseases have a significant impact on the mortality rate and the length of hospital stay among COVID-19 patients. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was discovered in China in 2019, is an ongoing pandemic. 1 In March 2021, it was reported that there are more than 117 million confirmed cases in the world, and the total number of deaths in the world is around 2,600,000 in 220 countries, with a mortality rate of around 2%. 2 In Saudi Arabia, there were around 380,000 confirmed infected cases by January 2021, and a mortality rate of around 1.7%. 3 Patients with COVID-19 usually complain of fever, cough, fatigue, anorexia, myalgia, and diarrhoea, 4 but in severe illness, usually dyspnoea is the most common symptom often accompanied by hypoxemia. 4 Mortality rates depend on patients who have severe respiratory failure related to interstitial pneumonia and acute respiratory distress syndrome, 5 but higher mortality is found in association with older age, male sex, pre-existing cardiovascular diseases, uncontrolled diabetes, hypertension, asthma, chronic lung disease, and d-dimer greater than 1 μg/mL at admission. 6 Length of hospital stay due to the COVID-19 depends on patients' clinical situation, however, it also depends on local guidelines in the institution or local health authority and the capacity of hospitals. 7, 8 COVID-19 pandemic is a major strain on health and economic systems, and the demand for inpatients' facilities is increasing with the increase in the number of infected cases. 9 Predicting factors associated with the need for hospitalisation and length of stay can be important to help in aid prioritizing patients, decision-making and contingency planning. 10 This study aimed to identify the predictors of mortality and length hospital of stay in COVID-19 patients. A retrospective cross-sectional study was conducted at Al-Noor Specialist Hospital in Mecca, Saudi Arabia. Al-Noor Specialist Hospital is a tertiary hospital in Mecca, Saudi Arabia, and it is part of the Ministry of Health. The description of the study settings and the hospital has been described previously. 11 All patients had a confirmed COVID-19 diagnosis by a real-time polymerase chain reaction (PCR). The PCR samples were obtained through a nasopharyngeal swap. All patients were admitted between March 15, 2020, and June 15, 2020 and they were followed up for a time to assess the clinical outcome; and the final date of follow-up was August 15, 2020 . Data collection were between March 2020, and August 2020. All patients who were admitted and had a confirmed diagnosis of COVID-19 during the study period were included in the study. Data were collected from patients' files and electronic records using a unique medical record number (MRN) for each patient. All data were collected, reviewed and checked by a medical team, including medical residents and a consultant pulmonologist. Data included the patient's demographics, clinical symptoms, comorbidity, and laboratory findings. Data were collected at the time of admission to the hospital. Patients were classified according to their severity based on the following category: mild, moderate, severe and, critically severe disease. The definition of these categories has been described previously. 11 The primary outcome was predictors of patients' admission to an intensive care unit. Secondary outcomes were to identify predictors of length of hospital stay and mortality. The study protocol and study methodology were approved by the Ministry of Health's Institutional Review Board (IRB), as well as the hospital (No H-02-K-076-0920-386). Patients informed consent were obtained and patients were informed that their clinical data would be used for clinical or research purposes, while keeping all their personal information confidential. The ethical principles of the Declaration of Helsinki were adhered to during collection, handling, and storage of data, and all care was taken to protect patient confidentiality. Descriptive statistics were used to describe patients' demographics, laboratory findings, and clinical outcomes. Independent sample t-test was used to compare the mean value for continuous variables. A Chi-squared test/Fisher test was used to compare proportions for categorical variables. Multiple logistic/linear regression analysis was used to identify predictors of death and length of stay at the hospital, and a confidence interval of 95% (p < 0.05) was applied to represent the statistical significance of the results. All statistical analyses were conducted using SPSS (Statistical Package for the Social Sciences) version 25.0 software (SPSS Inc.). Fever was the most common symptom at presentation (72.4%, n= 511), followed by cough (63.0%, n= 445), and shortness of breath (56.4%, n= 398) ( Table 2) . Fever, cough, shortness of breath, nausea/vomiting, headache, loss of taste and smell, sputum were more common across severe and critical cases compared to others. Around 16.5% (n= 116) of the patients had white blood cell (WBC)> 10,000, 13.9% (n= 98) had WBC< 4000, and 21.0% (n= 148) of them had lymphocyte count <1500. About 12.6% (89) had platelet count < 150 and 29.9% (n= 210) had D.dimer >0.5. The proportion of patients who had WBC >10,000, lymphocyte count <1500, platelet count < 150, and D.dimer >0.5 increase as the severity of the disease increase in a statistically significant pattern (p<0.001). The mean Neutrophil-lymphocyte ratio (NLR) value was 9.9 (SD:33.5). The most common blood groups of COVID-19 patients were A+, O+, and B+ accounting for 35.7%, 28.6%, and 20.5% respectively (Table 3) . Regarding patients' inflammatory measures, around half of the patients had erythrocyte sedimentation rate (ESR)>10 mm/h and C-reactive protein (CRP)>0.3 mg/ dl. One-third of the patients had Ferritin>400mcg/L, and 1.8% of them had Procalcitonin>0.5ug/L. Concerning patients' liver function tests, around one-third of the patients had AST>40 and ALT>40. Additionally, 40.1% of them had lactate dehydrogenase (LDH)>230 U/L, and 6.2% had Bilirubin>18.7 umol/L. Regarding patients' (Table 3) . The median duration of stay at the hospital was 6.0 days (IQR: 300-10:00). The duration of stay in the hospital ranged from one day to 55 days. The prevalence rate of venous thromboembolism (VTE) among the patients was 3.0% (n= 21). More than half of the patients (63.6%; n= 450) pneumonia radiologically. At the end of the followup period, a total of 623 patients (91.6%) recovered. Three patients (0.4%) did not recover at the end of the follow-up, and 7.6% of the patients (n= 54) deceased while the remaining either transferred to other facility or still in the hospital, at last, follow up. The severity of the cases affected the recovery rate and mortality rate in a statistically significant way (p>0.001) ( Several factors were associated with increased risk of the length of stay, including comorbidities such as congestive heart failure, cerebrovascular accident, and COPD, fever, D.dimer value of more than >0.5, WBC>10,000, ESR>10 mm/h, CRP>0.3 mg/dl, ferritin > 400 mcg/L, procalcitonin >0.5 ug/L, LDH>230 U/L, creatinine >115 umol/L, and blood group O (p<0.05), for further details, please refer to Table 5 . In this cross-sectional study, we investigated the predictors of mortality and length of stay in hospital among hospitalised patients with COVID-19. The key findings of this study are that age, patients with chronic comorbidities, patients with VTE and radiological evidence of pneumonia, and higher D-dimer values were important risk factors that were associated with a higher risk of death and increased length of stay in hospital. Our findings revealed the significant impact of age and chronic conditions on the mortality rate and the length of hospital stay. It comes as no surprise that the escalated rate of mortality and prolonged hospital stay was associated with older patients. Thus this study substantiates the previous findings of the literature. 12 This may also be due to their weak immune system and some behavioural responses in the measures taken. 13, 14 Chronic diseases demonstrate a significant influence on the outcomes; diabetes patients were more vulnerable to fatal consequences and longer hospitalisation compared to non-DM patients, which is consistent with results reported from the previous study. 15 Hypertensive patients have a propensity to express high mortality rate and stay hospitalised longer. Likewise, pre-existent cardiovascular and cerebrovascular events carry a high risk of death and a longer duration of hospitalisation. The effect of SARS-COV-2 on the vascular endothelium could be explained by the current understanding that angiotensin-converting enzyme 2 (ACE2) cellular receptors as the entry sites of SARS-COV2 as shown in different studies. 16, 17 There are several explanations for these results, Renin-Angiotensin system (RAAS) and inflammatory cytokines have been mentioned as mediators in severe outcomes among hypertensive patients. 18 Furthermore, the frequent utilisation of angiotensin-converting enzyme inhibitors (ACEIs) can lead to a decrease in angiotensin-converting enzyme (ACE) and an increase in the expression of ACE2 in the lungs which eventually facilitates the invasion of Covid-19 virus, 19,20 nonetheless this still controversial as illustrated by other studies. 21 Further, the severe viral virulence may lead to high oxygen demand, physiological and reflex tachycardia and aggravates the manifestation of coronary artery diseases accompanied by respiratory distress, finally, unfavourable outcomes will present. 22 Patients with chronic liver diseases (CLD) were also more susceptible to fatal consequences either death or a longer hospitalisation period. The confirmed laboratory findings emphasise the negative impact of Covid-19 on liver functions. The previous study elucidated the high mortality rate among CLD patient who they are Covid-19 infected. 23, 24 Our findings also highlighted the high mortality rate and the long period of hospitalisation among cancer patients. The nature of cancer and the antineoplastic agents compromise the immune system. Consequently, it spikes the probability of lethal and severe infection of the Covid-19 virus among these patients. Moreover, the redundant clinical visits for follow up and chemotherapy dose also expose the patients to the infection. 25 The hypercoagulability of Covid-19 patients was observed and confirmed by laboratory findings. Venous thrombus embolism was one of the poor outcomes among covid-19 patients with a significant correlation and high odd ratios. The severe infection and long bed-ridden interval in ICU dysregulate the homeostasis of the cascade system by activating the inflammatory cytokines. 26 Not withstanding, the pathogeneses of VTEinduced by Covid-19 are complex and multifactorial. Our study provides further evidence of Covid-19 pneumonia as a predictor for the high mortality rate and prolonged hospitalisation. These findings support the aggressive preventive measures that be taken to halt the mortality rate among these patients. In our study, we found no significant difference between blood group type and the risk of death. However, we found a significant difference in the duration of hospital stay for patients with blood group O. Previous reports showed a reduced prevalence of Covid-19 27 However, this was later contradicted, as some other published report suggested that there is no link between Covid-19 infection and type of blood group. 28, 29 Future studies on a larger scale and different populations are needed to investigate this association. In our study and similar to published reports, patients with chronic obstructive pulmonary disease (COPD) were found to be at higher risk for a severe outcome, 30 likely due to the fact that these patients usually have reduced lung function along with various comorbidities. 31 Interestingly, on the other hand, patients with pre-existent asthma did not have a risk of worse outcome, 32 and this could be partly explained by the lower expression of ACE2 in asthmatic bronchial epithelium. 33 Obesity is one of the major comorbidities to be considered. Above increasing the risk of different complications such as DM, liver diseases and cardiovascular diseases, we observed obesity also increases the mortality rate and the demand on intensive care facilities among SARS-COV-2 patients, which augments the findings in a previous systematic review. 34 Henceforth, obesity is one of the potential predictors for the study outcomes. However, the underlying mechanism behind the bad prognosis of obese patients still unknown. We believe that our results are similar to the literature, it may help in earlier risk stratification, and triage of COVID-19 patients admitted to the hospital and in reducing the overload on emergency departments visits and intensive care units in order to facilitate COVID-19 cases and other emergency care cases. Some factors identified in this study, such as older age and comorbidities, may help policymakers and guidelines in their recommendations about prioritising patients based on their symptoms and may help to improve the patient's care. Furthermore, the founded risk factors might be helpful in establishing a scoring system that can be applied to predict mortality and appropriate management plan. This study has some limitations. First, the study population only included patients from a single-centre hospital in Saudi Arabia. Second, the cross-sectional study design restricted our ability to identify causality between study variables. Hospitalised COVID-19 patients have multiple negative consequences in term of their laboratory findings, signs and symptoms. Age and chronic conditions have a significant impact on the mortality rate and the length of hospital stay among COVID-19 patients. Earlier risk stratification of the COVID-19 patients admitted to the hospital is recommended. 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Association of respiratory allergy, asthma, and expression of the SARS-CoV-2 receptor ACE2 Obesity is associated with increased severity of disease in COVID-19 pneumonia: a systematic review and meta-analysis Journal of Multidisciplinary Healthcare 2021:14 submit your manuscript | www Alelyani, Abdulrhman Basfar, Abdulaziz Al Barakati, Ghaidaa F Alsharif, Elaf F Obaid, Basil Alotaibi and Hassan Alwafi. All authors contributed to data analysis, drafting or revising the article, have agreed on the journal to which the article will be submitted, gave final approval of the version to be published, and agree to be accountable for all aspects of the work. The authors have stated explicitly that there are no conflicts of interest in connection with this article. The Journal of Multidisciplinary Healthcare is an international, peerreviewed open-access journal that aims to represent and publish research in healthcare areas delivered by practitioners of different disciplines. 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