key: cord-0738635-mtibnmph
authors: Ojeda, Antonio; Calvo, Andrea; Cuñat, Tomas; Mellado‐Artigas, Ricard; Comino‐Trinidad, Oscar; Aliaga, Jorge; Arias, Marilyn; Ferrando, Carlos; Martinez‐Pallí, Graciela; Dürsteler, Christian
title: Characteristics and influence on quality of life of new‐onset pain in critical COVID‐19 survivors
date: 2021-12-15
journal: Eur J Pain
DOI: 10.1002/ejp.1897
sha: e8bf5c7632d3784cf38509c66775c966f8e0d865
doc_id: 738635
cord_uid: mtibnmph

BACKGROUND: Pain is a clinical feature of COVID‐19, however, data about persistent pain after hospital discharge, especially among ICU survivors is scarce. The aim of this study was to explore the incidence and characteristics of new‐onset pain and its impact on Health‐Related Quality of Life (HRQoL), and to quantify the presence of mood disorders in critically ill COVID‐19 survivors. METHODS: This is a preliminary report of PAIN‐COVID trial (NCT04394169) presenting a descriptive analysis in critically ill COVID‐19 survivors, following in person interview 1 month after hospital discharge. Pain was assessed using the Brief Pain Inventory, the Douleur Neuropathique 4 questionnaire and the Pain Catastrophizing Scale. HRQoL was evaluated with the EQ 5D/5L, and mood disorders with the Hospital Anxiety and Depression Scale (HADS). RESULTS: From 27 May to 19 July 2020, 203 patients were consecutively screened for eligibility, and 65 were included in this analysis. Of these, 50.8% patients reported new‐onset pain; 38.5% clinically significant pain (numerical rating score ≥3 for average pain intensity); 16.9% neuropathic pain; 4.6% pain catastrophizing thoughts, 44.6% pain in ≥2 body sites and 7.7% widespread pain. Patients with new‐onset pain had a worse EQ‐VAS and EQ index value (p < 0.001). Pain intensity was negatively correlated to both the former (Spearman ρ: −0.546, p < 0.001) and the latter (Spearman ρ: −0.387, p = 0.001). HADS anxiety and depression values equal or above eight were obtained in 10.8% and 7.7% of patients, respectively. CONCLUSION: New‐onset pain in critically ill COVID‐19 survivors is frequent, and it is associated with a lower HRQoL. Trial registration No.: NCT04394169. Registered 19 May 2020. https://clinicaltrials.gov/ct2/show/NCT04394169. SIGNIFICANCE: A substantial proportion of severe COVID‐19 survivors may develop clinically significant persistent pain, post‐intensive care syndrome and chronic ICU‐related pain. Given the number of infections worldwide and the unprecedented size of the population of critical illness survivors, providing information about the incidence of new‐onset pain, its characteristics, and its influence on the patients’ quality of life might help establish and improve pain management strategies.

Long-term physical or mental health status problems are common in critically ill patients after discharge from ICU. In 2012, a new medical term,'post-intensive care syndrome' (PICS), was adopted by the Society of Critical Care Medicine to refer to this entity (Elliott et al., 2014) . Currently, survivors 1 year after ICU admission outnumber the deceased by three to one (Brinkman et al., 2013 ). However, this success has come at the cost of increasing disability and decreasing survivors' quality of life (QoL), which also impacts negatively on caregivers Herridge et al., 2003 Herridge et al., , 2016 Torres et al., 2017) . Critical illness survivors display a high prevalence of moderate to extreme chronic pain, with the latter entailing a significant limitation in work and social activity, and becoming a major cause of disability in Europe (Barbaglia et al., 2017; Baumbach et al., 2016; Mäkinen et al., 2020) . Components of the PICS such as depression, anxiety, posttraumatic stress disorder (PTSD) and cognitive impairment are also prevalent in chronic pain. These problems show a bi-directional relationship and have been associated with a worse prognosis (Fishbain et al., 2017; Linton & Bergbom, 2011) .

COVID-19 has led to a large number of hospital admissions. As of 5 October 2021 more than 237 million cases of COVID-19 have been reported worldwide Dashboard, n.d.) , with up to 5% of patients requiring re-admission to the ICU Hozhabri et al., 2020) . Despite this large number of individuals that could be potentially affected by PICS and chronic ICU-related pain, there are no prospective studies to date reporting data on critically ill COVID-19 patients' pain, its characteristics, and its relationship with self-perceived QoL. Moreover, pain is a common symptom after acute COVID-19, and chronic pain could be another consequence of this disease (Carfì et al., 2020; Kemp et al., 2020; Meyer-Frießem et al., 2021) . Although scientific evidence is insufficient, prevention and early pain management could improve medium or long-term outcomes, so it is imperative to call for proper identification and management of this condition (Katz et al., 2015; Mills et al., 2019) .

The hypothesis was that survivors of critical COVID-19 would often present with pain and display a decrease in self-perceived QoL, as well as an increased incidence of anxiety and depression disorders (Inoue et al., 2019) . The aim of the study is to investigate the prevalence and characteristics of new-onset pain in COVID-19 ICU survivors 1 month after hospital discharge. Additional objectives include the assessment of the relationship between newonset pain and pain intensity with QoL via the Healthrelated Quality of Life (HRQoL) questionnaire and the quantification of the presence of mood disorders.

This is a preliminary descriptive report of an ongoing single-centre clinical trial aiming to assess the efficacy of a combined intervention program to mitigate chronic pain in COVID-19 ICU survivors (NCT04394169). The study was approved by the Ethics Committee of the Hospital Clinic of Barcelona (approval number HCB/2020/0549) on 14 May 2020. The study protocol has been submitted for publication (Ojeda et al., 2021) . Participants were enrolled 1 month after hospital discharge after giving their written informed consent. All study procedures were performed following the ethical standards of the Declaration of Helsinki. This study followed the 'Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)' statement guidelines for observational cohort studies (von Elm et al., 2007) .

Adult survivors from critically severe COVID-19 infection-confirmed by polymerase chain reaction-based tests on respiratory tract samples-with at least one of the following inclusion criteria were eligible for participation: (i) an Acute Physiology and Chronic Health Evaluation (APACHE) II score at ICU admission >14; (ii) an ICU length of stay over 10 days; (iii) ICU-acquired Weakness; (iv) delirium during ICU admission. These criteria were in accordance with those previously recommended for critical illness monitoring and rehabilitation program (Busico et al., 2019) ; delirium was added as it has been associated with long-term cognitive and functional deficits in multiple studies (Rengel et al., 2019; Sampson et al., 2020) . The exclusion criteria were the following: (i) central nervous information about the incidence of new-onset pain, its characteristics, and its influence on the patients' quality of life might help establish and improve pain management strategies. system degenerative disease; (ii) terminal illness; (iii) insufficient understanding of the Spanish language; (iv) difficulty in completing follow-up due to a living distance >50 km from the Hospital Clínic of Barcelona; (v) not providing informed consent for the study (for details, see Methods S1).

The site's clinical database allowed identification of all the patients who were discharged from the intensive care units, and those who met the inclusion criteria were recruited.

One month after their discharge from hospital, these patients were contacted via a phone call to check whether they would be interested in participating in this trial and were invited to an introductory interview in which they received information about the study.

After enrolment, a baseline in person interview was conducted by researchers (AC, TC, OC-T, JA, MA) 1 month after hospital discharge. Demographic and socioeconomic data along with medical history-including mental health and chronic pain disorders-were collected. The presence of previous chronic pain was evaluated using the definition proposed by Baumbach et al. (2018) : 'more than occasional pain (e.g. short headache/toothache) in the last 4 weeks before ICU admission' (see Methods S1). Information regarding their recent ICU stay also was included. Finally, questionnaires were self-administered to assess pain, QoL and mood disorders (see Methods S1 for demographic and patient characteristics variables definitions).

2.3.1 | New-onset pain and its characteristics Pain was evaluated via the Brief Pain Inventory short form questionnaire (BPI-SF) (Cs & Km, 1994 ) (see Appendix S1). The definition of new onset-pain was an affirmative answer to the first question of the BPI-SF questionnaire: 'Throughout our lives, most of us have had pain from time to time (such as minor headaches, sprains and toothaches). Have you had pain other than these everyday kinds of pain?'. If the answer was positive, the Investigator confirmed the presence of new-onset pain after verifying that the pain was not present before admission to ICU or prior to Covid-19 infection. The patients were instructed not to consider acute covid symptoms when asked whether they had pain prior to ICU admission.

Pain location, intensity and interference in daily life activities were registered using the specific BPI-SF questionnaire. Following the Initiative on Methods, Measurements, and Pain Assessment in Clinical Trials (IMMPACT) recommendations, clinically meaningful pain was defined by a numerical rating score (NRS) ≥3 for average pain intensity (Gewandter et al., 2015) . Widespread pain was also assessed (see Methods S1.) Every time new-onset pain was detected, neuropathic pain (NP) and pain catastrophizing were screened and assessed with the Douleur Neuropathique 4 interview questionnaire (DN4-interview) (see Appendix S2) and the Pain Catastrophizing Scale (PCS) (see Appendix S3), respectively (Bouhassira et al., 2005; Darnall et al., 2017) . A score ≥30 in the PCS was considered as a clinically relevant level of catastrophizing (Darnall et al., 2017) . Once a positive NP screen was obtained, the affected anatomical area was confirmed by the Investigator.

HRQoL, as assessed by the EQ 5D/5L (Herdman et al., 2011 ) (see Appendix S4), determines the QoL according to a descriptive system, a visual analogic scale (VAS) and an index value. The descriptive system evaluates five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression, each scored according to a scale of 1 (no problems) to 5 (extreme problems). Responses are coded as single-digit numbers expressing the severity level selected for each dimension. The digits for the five dimensions can be combined in a 5digit code that describes the respondent's health state. The VAS measures the patient's perception of their overall current health, from 0-the worst imaginable health-to 100-the best imaginable health. An index value can also be obtained by applying a formula that attaches values (weights) to each of the levels in each dimension. The index is calculated by deducting the appropriate weights from 1, the value for full health (i.e. state 11111) (EuroQol Research Foundation, 2019). The index was obtained by using the EQ 5D/5L Index Value Calculator (Developed by the EuroQol Group Version 2.0.) (Van Hout et al., 2012).

The EQ-VAS and index values between individuals presenting with pain and those without pain were compared. The relationship between pain intensity and HRQoL was also assessed.

The presence of anxiety and/or depression was assessed by the Hospital Anxiety and Depression Scale (HADS) (Bjelland et al., 2002) (see Appendix S5). According to Bjelland's review, values equal or greater than a cut-off point of 8 were considered abnormal anxiety or depression values (Bjelland et al., 2002) . Additionally, the relationship between anxiety, depression, HRQoL, and new-onset pain was also assessed.

No sample size calculation was carried out for this preliminary analysis. Notably, during this descriptive project analysis, no outcomes for the ongoing clinical trial were assessed. Continuous variables were expressed as median (interquartile range), and categorical variables were presented as numbers (percentages). Missing data were minimal (below 0.5%) and missing observations were not imputed. Comparisons between groups were conducted with either the Fisher or the Mann-Whitney test. Correlations between ordinal variables were analysed with Spearman's Rho without accounting for any order interactions. A threshold of 0.05 was used for statistical significance. All reported tests are two-sided. The R software was used for all the analysis (R Foundation for Statistical Computing).

From 27 May to 19 July 2020, 203 critically ill COVID-19 ICU survivors were consecutively screened; 65 patients were finally included in the study and they completed the questionnaires. These cases belong to the first wave of the COVID-19 pandemic in Spain. Patients´ flowchart is shown in Figure 1 . A summary of demographics and characteristics for patients without new-onset pain, patients with newonset pain, and for both groups are presented in Table 1 .

Comparison between 'No pain' and 'New onset pain' patients identified as factors significantly associated with the development of new onset pain among severe COVID-19 survivors: a younger age, a lower Charlson Comobirdity Index Score, a higher SOFA, mechanical ventilation, use of neuromuscular blocking agents and the use of vasopressor therapy (Table 1 ).

Thirty-three (50.8%) patients presented new-onset pain; 25 (38.5%) reported clinically significant pain (NRS ≥3 for average pain intensity); 18 (27.6%) had a BPI-SF intensity score ≥3 and a BPI-SF interference score ≥3; 10 (15.4%) F I G U R E 1 Patient inclusion flowchart. Covid-19 ICU Survivors meeting PAIN-COVID trial inclusion/ exclusion criteria were contacted before 1 month after hospital discharge. A total of 65 patients were included for the analysis. Difficulty in completing followup: home distance over 50 km from the Hospital Clinic of Barcelona patients reported NP, and 3 (4.6%) patients had a clinically relevant level of catastrophizing.

Among those experiencing new-onset pain, median BPI average pain item was 4 (IQR 3-5), median BPI-SF score was 3 (IQR 2-4) for intensity and 3 (IQR 1-5) for interference. Figure 2 shows the BPI average pain item and its self-perceived impact on daily life activities.

Twenty-nine (44.6%) patients reported pain in two or more body locations, and 5 (7.7%) reported widespread pain. Upper extremities were the most affected body location (18 [27.7%] patients), followed by lower extremities (12 [18.5%] patients); 10 (15.4%) patients reported shoulder pain. Figure 3 T A B L E 1 Summary of demographics and characteristics of patients without new onset pain, with new onset pain, and for both groups (all patients)

All patients ( 29 3 No No No No No No No No No No No No No No No shows a body map with the percentage of pain reported in each anatomical area.

Of the 8 (12.3%) patients who reported previous chronic pain, 6 (9.2%) had new-onset pain, and 4 (6.2%) experienced worsening of their previous chronic pain. The main features of these patients are shown in Table 2 .

Ten of 33 (30%) patients with new-onset pain had a positive screen for NP, the affected areas being: Both feet (n = 3), leg and foot (n = 2), foot (n = 1), thigh (n = 1), shoulder girdle (n = 1) and upper limb (n = 1). Table 3 summarizes the characteristics of these patients. It should be noted that 8 of 10 patients with NP presented ICU-acquired weakness.

Only 9 (5.8%) patients reported self-perceived full health status. Median EQ Index Value was 0.8 (IQR 0.57-0.87), and median EQ VAS was 70 (IQR 60-80). (See Table S1 for EQ 5D/5L frequencies and proportions reported for each dimension and level.) 

In 7 (10.8%) patients a HADS anxiety value ≥ of 8 was reported, and 5 (7.7%) patients displayed a HADS depression value ≥8. Anxiety was related to a worse HRQoL in the EQ index value ( New-onset pain occurred in 3 of the 7 patients with a HADS anxiety value ≥8 (p = 0.71), and in 4 of the 5 patients with a HADS depression value ≥8 (p = 0.36).

To the best of our knowledge, this is the first study that prospectively assesses the incidence of new-onset pain, its characteristics, and its influence on the QoL in very severe COVID-19 survivors.

Murat et al. exanimated the characteristics of pain in COVID-19 (Murat et al., 2020) . However, prospective studies evaluating the incidence and characteristics of persistent pain after infection are non-existent (Meyer-Frießem et al., 2021) .

Pain research after COVID-19 is starting, so it is necessary to establish an appropriate terminology. Soares et al. proposed a classification (Pain not related to COVID-19; Pain directly related to COVID-19; and Pain aggravated by COVID-19) (Soares et al., 2021) , that could not be adapted to the current study because it could not be assumed that new-onset pain was related to COVID-19 in all patients since it is also frequent in other critical illness survivors (Baumbach et al., 2016; Koster-Brouwer et al., 2020) .

Most studies assessing pain in ICU survivors, and after COVID-19, use a subdomain of the QoL scales (Kemp et al., 2019; Taboada et al., 2020) . Consensus statement on physical rehabilitation in ICU survivors recommend to assess pain using the VAS (Major et al., 2016) . However, given the multidimensional nature of pain, appropriate management will only be achieved after detailed assessment with specific instruments (Bendinger & Plunkett, 2016) .

Half of the critical COVID-19 survivors reported new pain in the first month after hospital discharge, and that was frequently associated with a significantly worse QoL.

Studies evaluating new-onset pain in ICU survivors reported an incidence between 18% and 44% (Battle et al., 2013; Baumbach et al., 2016; Koster-Brouwer et al., 2020) . In COVID-19 patients, a prevalence of new-onset pain of around 19% had been informed (Caronna et al., 2020; Soares et al., 2021) . Comparison of the current results with the previously reported ones is difficult, due to the impossibility to assess chronic pain according to widely used criteria, also because of the short period of time allocated to pain assessment (Treede et al., 2015) , and due the characteristics of the study population (severe critical illness survivors).

Despite the study limitations and given the large number of patients that can be affected with this problem worldwide, the authors believe it is essential to report these findings, that also include the identification of factors associated with new onset pain (Table 1) .

4.1.1 | Severity 38.5% and 75.8% of patients reported clinically significant pain, and new-onset pain respectively. This is a critical finding, because pain intensity is a risk factor to develop chronic pain (Fletcher et al., 2015; Mills et al., 2019) .

As it has been observed in non COVID-19 ICU survivors' studies, most subjects with new-onset pain (87.9%) reported pain in multiple body areas. Similarly, shoulder pain was frequently reported (30%) (Battle et al., 2013) . The shoulder is susceptible to muscle atrophy resulting from neuromuscular relaxation, corticosteroid therapy, sedation and mechanical ventilation (Koster-Brouwer et al., 2020) , implantation of invasive devices in the area (Battle et al., 2013) and/or manoeuvres used to move the patients, often depending on the pressure exerted on the joint (Yachou et al., 2020) . Brachial plexus injury during prone positioning for mechanical ventilation has been identified as another potential cause (Guérin et al., 2020) . Therefore, a protocol for proning procedures and the identification of pain and functional limitation after patient extubation is desirable (Quick & Brown, 2020) .

Widespread pain was observed in 15.2% of patients reporting new-onset pain. A chronic fibromyalgia-like symptoms after severe acute respiratory syndrome has been described (Moldofsky & Patcai, 2011) , with neuroinflammation being a possible pathophysiological factor. Thus, further studies are needed to demonstrate generalized hyperalgesia (suggesting central sensitization) using quantitative sensory testing (Kemp et al., 2020) .

Thirty percent of patients suffering from new-onset pain had a positive screening for NP. Chronic NP pain has been reported in non-COVID-19 ICU survivors (Baumbach et al., 2017; Koster-Brouwer et al., 2020) . Despite the fact that the DN4 questionnaire is only validated for chronic pain patients (Hansson et al., 2019) , NP in the early stages is linked with chronic NP development, (Beloeil et al., 2017; Martinez et al., 2012; Searle et al., 2009) and this, in turn, with QoL impairment (Colloca et al., 2017) . Thus, early management of this condition is believed to be essential.

Small nerve fiber pathology might present as NP with different patterns (Devigili et al., 2008) and is common in ICU survivors {Citation} (Baumbach et al., 2017; Latronico et al., 2013) . Thirty-three percent of patients with NP presented with allodynia or hyperesthesia in one foot and leg, suggesting peroneal nerve injury. Prolonged immobility, muscle atrophy, and contracture can cause peroneal nerve compression (Rubinos & Ruland, 2016) . To avoid compression neuropathies, proper patient positioning in bed is crucial (Grigoriadis et al., 2009) . Critical F I G U R E 4 New-onset pain and Health Related Quality of Life. (a) Correlation between BPI average pain intensity item and EQ VAS. (b) Correlation between BPI average pain intensity item and EQ Index. BPI-SF, Brief Pain Inventory Short Form; VAS, visual analogue scale illness polyneuropathy has been previously described (Kemp et al., 2020) , and the results of this study showed that 80% of patients with NP had ICU-acquired weakness. Moreover, in our study, 70% of patients with NP reported pain in the lower extremities, suggesting that polyneuropathy may explain a significant proportion of new-onset NP in this population. The presence of unilateral NP in the foot, may suggest the appearance of a mononeuropathy or early stages of a polyneuropathy.

Human coronaviruses are neurotropic, and their association with neuroinflammation and various neurological disorders is well documented (Yachou et al., 2020) . Moreover, the COVID-19 virus can trigger a cytokine storm in specific populations, with immediate-but also probably lasting-effects on the nervous system (Wu et al., 2020) . Although there are no conclusive data about the persistence of neuroinflammation in COVID-19 survivors, NP could be a manifestation of this process.

Seventy-five percent of patients with chronic pain had new-onset pain. This finding is in line with previous reports, with chronic pain in another location being an important risk factor for developing new chronic pain. (Mills et al., 2019) . However, the use in this study of a chronic pain definition based on the work of Baumbach et al. (2016) , which has broader criteria than the IASP definition (Treede et al., 2015) , might lead to an overestimation of previous chronic pain incidence.

A lower prevalence of anxiety and depression was found in this population when compared to previously documented prevalence in non-COVID-19 ICU survivors at 2 and 3 months after hospital discharge (Davydow et al., 2009; Hatch et al., 2018) . Alternatively, patients could develop a post-traumatic growth, defined as positive changes that a person can experience due to struggling with trauma (Tedeschi & Calhoun, 1996) . The Polyanna Syndrome, described as being 'blind optimistic' to a bad situation (Sirgy, 2002) , could also explain the unexpected low incidence of depression given the survival to the pandemic.

The EQ VAS evidenced that they had a better perception of their health status than expected, which could be related to the feeling of being a survivor of the pandemic.

Additionally, there is controversy about the impact of ICU-delirium on QoL after hospital discharge (Abelha et al., 2013; Luz et al., 2020) . In this study, ICU-delirium was included as inclusion criteria, although not a mandatory one and it might have led to the underestimation of HRQoL scores. However, in our results, patients with ICU-delirium did not show a worse EQ index value compared to patients without vs. 0.8 [0.58-0.88], p = 0.55).

Clinically significant pain was correlated with worse HRQoL, and these findings have been described for many pathologies, usually related to an injury as a trigger of pain (Langerud et al., 2018) . This association sheds light on the importance of improving the characterization of physical and mental trajectories after ICU admission to provide the best long-term patient care.

The main limitation of this study is the small size of the cohort from a single centre and the lack of a control group of non-COVID-19 ICU survivors. In addition, this preliminary analysis of the PAIN-COVID cohort trial is purely descriptive and, as sample size was not calculated, some of the results could be unpowered.

Second, PAIN-COVID trial excludes patients with neurodegenerative diseases (Carniglia et al., 2017) , and includes patients with ICU-acquired weakness and delirium, which are related to persistent pain, and could have led to an over-estimation of new-onset pain.

Moreover, data were analysed 1 month after hospital discharge and therefore some components of PICS, such as PTSD and new-onset chronic pain, were left out of the analysis. Also, the chronic pain definition used when collecting basal patient characteristics may limit the comparison of this study findings with other studies', and eventually undiagnosed persistent cognitive impairment after ICU-delirium may lead to error when completing the questionnaires.

In this prospective, observational study, new-onset pain was found to be frequent in critically ill COVID-19 survivors 1 month after hospital discharge. Pain was associated with daily life activity limitations and with a lower HRQoL. Characteristics of this new-onset pain were also described to help determine the best strategies for managing this healthcare problem in future studies.

Outcome and quality of life in patients with postoperative delirium during an ICU stay following major surgery

Health conditions and role limitation in three European Regions: A public-health perspective

Chronic pain in survivors of critical illness: A retrospective analysis of incidence and risk factors

Prevalence and characteristics of chronic intensive care-related pain: The role of severe sepsis and septic shock

Somatosensory functions in survivors of critical illness

Chronic intensive care-related pain: Exploratory analysis on predictors and influence on health-related quality of life

Early postoperative neuropathic pain assessed by the DN4 score predicts an increased risk of persistent postsurgical neuropathic pain

Measurement in pain medicine

The validity of the Hospital Anxiety and Depression Scale. An updated literature review

Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)

Mortality after hospital discharge in ICU patients*

Follow-up program after intensive care unit discharge

One-year outcomes in caregivers of critically ill patients

Gemelli Against COVID-19 Post-Acute Care Study Group

Neuropeptides and microglial activation in inflammation, pain, and neurodegenerative diseases

Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution

Neuropathic pain

Pain assessment: Global use of the Brief Pain Inventory

Development and validation of a daily pain catastrophizing scale

Depression in general intensive care unit survivors: A systematic review

The diagnostic criteria for small fibre neuropathy: From symptoms to neuropathology

Exploring the scope of post-intensive care syndrome therapy and care: Engagement of non-critical care providers and survivors in a second stakeholders meeting

Características, evolución clínica y factores asociados a la mortalidad en UCI de los pacientes críticos infectados por SARS-CoV-2 en España: Estudio prospectivo, de cohorte y multi-céntrico

Chronic pain types differ in their reported prevalence of post -traumatic stress disorder (PTSD) and there is consistent evidence that chronic pain is associated with PTSD: An evidence-based structured systematic review

euCPSP group for the Clinical Trial Network group of the European Society of Anaesthesiology

Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations

Pressure exerted in the peroneal nerve depending on the different positions in the intensive care unit bed

Prone position in ARDS patients: Why, when, how and for whom

Acute neuropathic pain: Equivalent or different to chronic neuropathic pain? A call for gathering of scientifically based information on acute neuropathic pain

Anxiety, Depression and Post Traumatic Stress Disorder after critical illness: A UK-wide prospective cohort study

Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L)

One-year outcomes in survivors of the acute respiratory distress syndrome

The RECOVER program: Disability risk groups and 1-year outcome after 7 or more days of mechanical ventilation

The global emergency of novel coronavirus (SARS-CoV-2): An update of the current status and forecasting

Post-intensive care syndrome: Its pathophysiology, prevention, and future directions

The Toronto General Hospital Transitional Pain Service: Development and implementation of a multidisciplinary program to prevent chronic postsurgical pain

Chronic pain after COVID-19: Implications for rehabilitation

Chronic pain in critical care survivors: A narrative review

Occurrence and risk factors of chronic pain after critical illness

Health-related quality of life in intensive care survivors: Associations with social support, comorbidity, and pain interference

Small nerve fiber pathology in critical illness

Understanding the link between depression and pain

Delirium and quality of life in critically ill patients: A prospective cohort study

Surviving critical illness: What is next? An expert consensus statement on physical rehabilitation after hospital discharge

Persistent pain in intensive care survivors: A systematic review

Risk factors predictive of chronic postsurgical neuropathic pain: The value of the iliac crest bone harvest model

Pain during and after COVID-19 in Germany and worldwide: A narrative review of current knowledge

Chronic pain: A review of its epidemiology and associated factors in population-based studies

Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study

Clinical presentations of pain in patients with COVID-19 infection

Rationale and study design of an early care, therapeutic education, and psychological intervention program for the management of post-intensive care syndrome and chronic pain after COVID-19 infection (PAIN-COVID): Study protocol for a randomized controlled trial

A commentary on Prone Position Plexopathy during the COVID-19 pandemic

Long-term cognitive and functional impairments after critical illness

Neurologic complications in the intensive care unit

Pain and delirium: Mechanisms, assessment, and management

Can chronic neuropathic pain following thoracic surgery be predicted during the postoperative period?

The psychology of quality of life

Prevalence and characteristics of newonset pain in COVID-19 survivours, a controlled study

Quality of life, functional status, and persistent symptoms after intensive care of COVID-19 patients

The Posttraumatic Growth Inventory: Measuring the positive legacy of trauma

The impact of the patient post

A classification of chronic pain for ICD-11

Interim Scoring for the EQ-5D-5L: Mapping the EQ-5D-5L to EQ-5D-3L value sets

Strengthening the reporting of observational studies in epidemiology (STROBE) statement: Guidelines for reporting observational studies

Nervous system involvement after infection with COVID-19 and other coronaviruses

Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: Understanding the neurological manifestations in COVID-19 patients

The authors thank the staff of the Pain Unit and the Surgical Intensive Care Unit.

The authors declare that they have no conflict of interest.

All authors contributed to the study conception and design. The study was designed by Dr Ojeda. Preparation, patient recruitment and data collection were performed by Dr Calvo, Dr Cuñat, Dr Comino-Trinidad, Dr Aliaga and Dr Arias. The first draft of the manuscript was written by Dr Ojeda and Dr Calvo, who share the first authorship of this manuscript; all the authors commented on previous versions of the manuscript. Dr Mellado-Artigas performed the data analysis. Dr Dürsteler, Dr Martinez-Pallí and Dr Ferrando reviewed the different contributions of all the authors and contributed to the structure of this manuscript. All the authors read and approved the final manuscript.ORCID Antonio Ojeda https://orcid.org/0000-0003-4950-1044