key: cord-0737847-vlmhsinv authors: Torbicki, Adam title: Pulmonary Hypertension: Diagnosis and Management date: 2021-06-09 journal: Diagnostics (Basel) DOI: 10.3390/diagnostics11061066 sha: ef529ce6894acdd20f3dee26b9f60ef264b949ba doc_id: 737847 cord_uid: vlmhsinv With great satisfaction, we now share with you the contents of this Special Issue of Diagnostics dedicated to Diagnosis and Treatment of Pulmonary Hypertension (PH) [...]. With great satisfaction, we now share with you the contents of this Special Issue of Diagnostics dedicated to Diagnosis and Treatment of Pulmonary Hypertension (PH). Our satisfaction is due to the outstanding contributions from leading PH expert centers worldwide. Those contributions include original data as well as excellent reviews of the state of the art and future perspectives covering several critically important problems related to PH. As an introduction, we invite you to a journey across the ages to discover milestones in understanding human pulmonary circulation. I have the pleasure to bring you from ancient China and Egypt through the Middle Ages, Renaissance and modern history, up to the moment when the first successful implementation of a human-made heart-lung machine definitively proved that our concepts of pulmonary circulation finally became correct [1] . The first section contains five papers dedicated to problems related to overlap of vascular and respiratory problems in the lungs-Olschewski's perspective from Ludwig Boltzmann Institute, University of Graz [2] is followed by a review of the state of the art in PAH associated with sclerodermia by Naranjo and Hassoun, from John Hopkins University, Baltimore [3] . The modern approach to thoracic imaging in patients with PH, including machine learning and artificial intelligence, is covered by outstanding reviews from a team from Sheffield University [4] , and Gibbs and Gopalan from Imperial College, London and Cambridge University, respectively [5] , while an attempt to link genetic background with radiological phenotyping in PVOD is reported from Hospital Universitario Doce de Octubre in Madrid [6] . From differential diagnosis, we move to risk stratification in PH with new biomarkers suggested by a group from Rome [7] , and a multiparametric non-invasive approach from Otwock, Poland [8] . An important, unexplored possibility of using an echocardiographically assessed right ventricular reserve as a prognostic factor is suggested from Heidelberg [9] . This part is completed by a comprehensive overview of the role of echocardiography for the assessment of PH in congenital heart disease in the young prepared by an expert group of pediatric cardiologists from Austria, Germany and the UK [10] . The impact of the COVID-19 pandemic on pulmonary hypertension is still unclear. This Special Issue presents two perspectives on its significance-an original report from a large University Hospital in New York City [11] and a review from Spain [12] , which was particularly heavily hit by the first wave of the pandemic, in 2020. Finally, two interventional methods still searching their optimal place within therapeutic strategy in PH are covered by five papers. An interesting report from the Bakoulev National Medical Research Center of Cardiovascular Surgery in Moscow on a large series of stent-protected atrial septostomies [13] is commented on by Prof Sandoval [14] , a global expert in this method from the Instituto Nacional de Cardiologia in Mexico City. Three original contributions deal with chronic thromboembolic pulmonary hypertension (CTEPH). A paper from Madrid addresses the issue of its operability [15] , crucial for the qualification to balloon pulmonary angioplasty (BPA), while Banaszkiewicz et al. from Otwock reports on a new marker associated with early complications of BPA [16] . Finally, a case report from our center, by Darocha et al., points at the possible role of BPA with stenting in cases of CTEPH with proximal stenoses prone to elastic recoil when surgical treatment is impossible due to severe comorbidities or decision of the patient [17] . Please pick your choices but also think about sharing your own data and experience by publishing on the open access pages of Diagnostics. You will be supported by an editorial team which-as the Guest Editor of this Special Issue-I found very friendly and efficient. The author declares no conflict of interest. Milestones in Understanding Pulmonary Circulation: From Antiquity to Heart-Lung Machine The Challenge to Decide between Pulmonary Hypertension Due to Chronic Lung Disease and PAH with Chronic Lung Disease Systemic Sclerosis-Associated Pulmonary Hypertension: Spectrum and Impact. Diagnostics 2021, 11, 911 Pulmonary Hypertension in Association with Lung Disease: Quantitative CT and Artificial Intelligence to the Rescue? State-of-the-Art Review From Early Morphometrics to Machine Learning-What Future for Cardiovascular Imaging of the Pulmonary Circulation? Diagnostics Radiological Findings in Multidetector Computed Tomography (MDCT) of Hereditary and Sporadic Pulmonary Veno-Occlusive Disease: Certainties and Uncertainties. Diagnostics 2021 Oltrona Visconti, L. Galectin-3 Plasma Levels Are Associated with Risk Profiles in Pulmonary Arterial Hypertension. Diagnostics 2020 Prediction of Prognostic Hemodynamic Indices in Pulmonary Hypertension Using Non-Invasive Parameters Right Heart Size and Right Ventricular Reserve in Pulmonary Hypertension: Impact on Management and Prognosis Echocardiography for the Assessment of Pulmonary Hypertension and Congenital Heart Disease in the Young COVID-19 in Pulmonary Artery Hypertension (PAH) Patients: Observations from a Large PAH Center Effect of Coronavirus Disease 2019 in Pulmonary Circulation. The Particular Scenario of Precapillary Pulmonary Hypertension Outcomes of Atrioseptostomy with Stenting in Patients with Pulmonary Arterial Hypertension from a Large Single-Institution Cohort The Long and Winding Road of Atrial Septostomy Feasibility of a Noninvasive Operability Assessment in Chronic Thromboembolic Pulmonary Hypertension under Real-World Practice Soluble ST2 as a Biomarker for Early Complications in Patients with Chronic Thromboembolic Pulmonary Hypertension Treated with Balloon Pulmonary Angioplasty Balloon Pulmonary Angioplasty with Stent Implantation as a Treatment of Proximal Chronic Thromboembolic Pulmonary Hypertension