key: cord-0733200-hhaltaw8
authors: Miyamoto, Katsuichi; Koh, Jinsoo; Takahashi, Maiko; Niwa, Mayako; Ito, Hidefumi
title: A case of anti-MOG antibody-positive ADEM following COVID-19 mRNA vaccination
date: 2022-03-19
journal: Neurol Sci
DOI: 10.1007/s10072-022-06019-6
sha: 46b67cbea767a13533963fd12371c7f538bf91ea
doc_id: 733200
cord_uid: hhaltaw8

nan

interleukin-2 receptor levels. Blood tests were negative for anti-aquaporine-4 antibody and other encephalitis-related auto-antibodies (glutamate receptors, leucine-rich gliomainactivated protein 1, contactin-associated protein 2, and glial fibrillary acidic protein).

Because the level of consciousness did not sufficiently improve, after three courses of steroid pulses, seven plasma exchanges (PE) were conducted upon which the level of consciousness improved, and the patient was able to speak in single sentences. At this point, bilateral abducens nerve palsy, facial paralysis, sluggish movement, and muscle stiffness became apparent, and intravenous immunoglobulin therapy (IVIg; 400 mg/kg/day for 5 days) was administered. As a result, she was able to walk unsteadily but unaided and was transferred to a rehabilitation hospital on the 57th day after her hospitalization. At this point, blood tests revealed anti-MOG antibody positivity. Three months after her discharge from our hospital, she had recovered well without relapse. She was able to perform activities of daily living independently.

Cases of ADEM after COVID-19 vaccination have been reported, although they are considered rare [2] [3] [4] . Many cases of encephalitis following COVID-19 vaccination have a history of immune-mediated disease, and most have a good outcome [5] .

Mumoli's case was mainly spinal cord lesion and was relieved by mPSL, while our case was mainly cerebral lesion and required PE and IVIg in addition to mPSL. Both cases had sequelae: urinary retention in Mumoli's case and higher brain dysfunction in our case. More similar cases need to be analyzed to study and prevent the disease. 

ADEM anti-MOG antibody-positive after SARS-CoV2 vaccination

Acute disseminated encephalomyelitis in a patient vaccinated against SARS-CoV-2

Acute disseminated encephalomyelitis after SARS-CoV-2 vaccination

Postvaccinal encephalitis after ChAdOx1 nCov-19

A systematic review of cases of CNS demyelination following COVID-19 vaccination