key: cord-0732211-ii2unc72
authors: Schaller, Tina; Märkl, Bruno; Claus, Rainer; Sholl, Lynette; Hornick, Jason L.; Giannetti, Matthew P.; Schweizer, Lisa; Mann, Matthias; Castells, Mariana
title: Mast cells in lung damage of COVID‐19 autopsies: A descriptive study
date: 2022-04-01
journal: Allergy
DOI: 10.1111/all.15293
sha: a86715dc9cd4cc76c9a9e2eea82df5394d110728
doc_id: 732211
cord_uid: ii2unc72

nan

To the editor, Mast cells were counted in low-and high-density areas ( Figure S1 ). While other forms of non-COVID-19-related lung injury showed a 3-5-fold increase in mast cell numbers between low-and high-density areas, acute COVID-19 DAD showed a <2fold increase (Figure 2) , indicating a suppression of mast cell proliferation which might be caused by high interferon levels in the early phase of COVID-19. In contrast, organizing DAD in COVID-19 lungs showed a 3-fold increase in mast cells between low-and highdensity areas. In general, the mast cell density varied considerably between COVID-19 lungs and the controls, as shown in Figure 1B . 

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All authors declare that they have no conflict of interest.