key: cord-0732189-5mcksa0a
authors: Khan, Zainab Aqeel; Allana, Raheel; Afzal, Irrum; Ali, Akbar Shoukat; Mariam, Omama; Aslam, Reema; Shah, Imran Ali; Allana, Asad; Mohsin Haider, M.; Jandani, Rahim; Khan, Zeeshan; Siddiqui, Athar M; Shah, Junaid Ali; Butt, Umer
title: Assessment of attitude and hesitancy towards vaccine against COVID-19 in a Pakistani population: A mix methods survey
date: 2021-09-07
journal: Vacunas
DOI: 10.1016/j.vacun.2021.08.002
sha: 1c9b1e382aeade8da60e07400e1c587a5f76a3c9
doc_id: 732189
cord_uid: 5mcksa0a

Objective:The objective of this study was to assess the attitude and hesitancy towards vaccine against COVID-19 in a Pakistani Population. Materials and Methods: A mix-method, prospective study was conducted and adults (aged ≥18 years) residing in Pakistan were invited to participate..The questionnaire was prepared, hosted in Google Forms and circulated through electronic platforms and was also available to be done in in-person. Data was compiled from 15th September to 30thNovember 2020. Results: The response rate was 80%. A total of 1003 participants were included in the final analysis. Of them, 75% completed survey questionnaire online, while remaining 25% responded in-person. The mean age of the participants was 29.62±10.47 years. The majority of participants were females; 60.9% (n=611). 57.02% (n=572) of the participants were employed at the time of survey. Overall, 70.68% (n=709) of the participants had previous experience of vaccines such as the flu vaccine Only 4.9% (n=49) participants thought that they will be seriously ill from COVID-19 within six months and 39% (n=392) participants were confident that they will get COVID-19. A total of 71.29% of the participants reported they would consider getting vaccinated once available. There was statistical association between gender and getting vaccinated (P<0.001). Conclusion: This study demonstrated that majority of the participants showed positive attitude towards considering COVID-19 vaccine. However awareness with informed knowledge of efficacy, possible adverse effects and cost would be of added great value to increase the real response of Pakistani population towards COVID-19 vaccination.

J o u r n a l P r e -p r o o f Introduction:

Vaccinationsare one of the most significant advances in public health history, despite widespread anti-vaccination sentiments, behavior, and misinformation [1] . Evidence has suggested that vaccinationsare efficient in protectingindividuals, preventing serious and life threatening diseases. Coronavirus disease 2019 , the highly contagious infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a catastrophic effect on the world's demographics resulting in more than 2.9 million deaths worldwide, emerging as the most consequential global health crisis since the era of the influenza pandemic of 1918. In order to prevent and protectindividualagainst COVID- 19 , there has been an implementation of the Covid-19 vaccination. COVID-19vaccinations are likewise exceedingly safe, with extremely minimal rates of serious side effects [2] .Countries across the world have begun vaccinating their population against COVID-19 in order to mitigate the effects of the pandemic, in addition to social distancing efforts [3] . Similarly, the Pakistani government took this critical step and began immunizing health care personnel first, followed by the general population, beginning with the elderly population and then the young, all while keeping COVID-19's severity in consideration.

In Pakistan, the roll out of the COVID vaccination is underway with 2,310,115 of the population fully vaccinated against COVID-19 [4] .

Despite concrete evidence that vaccinations are effective, there is growing concern about immunizations. Vaccine hesitancy has resulted in a decrease in vaccine uptake and an increase in the prevalence of vaccine-preventable diseases (VPDs) [5] . Surprisingly, the resistance to vaccinations is frequentasa result of their effectiveness because people are less likely to be exposed to VPDs. Hesitancy against the COVID-19vaccination is known all over the world, at a J o u r n a l P r e -p r o o f time when attempts to establish herd immunity through widespread vaccine coverage have been prioritized [6] .

Pakistan is a lower middle income country (LMIC) which has already been under the shadow of a high vaccine hesitancy country. During the COVID-19 outbreak, various conspiracy theories arose on social media against the COVID-19 vaccination. The Pakistani population is particularly vulnerable to such conspiratorial narratives. Among these are the alleged inadequate quality of vaccinations, the questioning of dose standards, religious buy-in, and suspicions about the presence of live virus in vaccines [7] .These beliefs are being heavily contested on social media amongst the Pakistani society. Such narratives are mostly to blame for the country's failure to eliminate polio. In addition, these narratives have created seeds of vulnerability and vaccine hesitancy against the ongoing COVID-19 immunization efforts amongst the Pakistani population.

Vaccine hesitancy is a key obstacle to the control of vaccine-preventable illnesses. A long-term lockdown is not a viable solution in many nations owing to economic instability. The uptake of vaccinations may be the only method to restrict the pandemic's endurance [8] . The tendency for disease transmission in Pakistan is significant due to the weak healthcare system, dense population, and low adherence to hygienic standards. Pakistan has previously faced strong vaccine hesitancy against to polio vaccination; therefore, any poor public impression of COVID-19 vaccinations will lead to disastrous consequences for efforts to stop the pandemic [9] .

The COVID-19 pandemic has shown a greater magnitude in terms of transmissibility and mortality compared to previous influenza pandemics. Countries around the world, including Pakistan, are under enormous pressure to monitor the current pandemic and avoid a potential recurrence of dangerous waves or epidemics in the future through mass vaccination uptake..

Vaccine hesitancy is on the rise, albeit it varies by country. In view of this, we aimed to assess the attitude and hesitancy towards the COVID-19 vaccination in the Pakistani population.

We conducted a mixed-method, prospective, study about COVID-19 amongst adult population in Pakistan in 2020. The aim of study was to explore the determinants of and correlation between the hesitancy of the COVID-19 vaccine and the belief in the sources of the novel coronavirus.

The inclusioncriterion for this study was an age restriction of 18 years old or older and a permanent Pakistani resident.

We used an anonymous online survey that respondents could opt to complete or not. The questionnaire was prepared, circulated and compiled using Google forms, an online tool that produces web-based surveys. Our questionnaire was adopted from a study conducted amongst the American population by Fisher et al. [10] . Our questionnaire was transmitted through social media to adults all over the Pakistan. All participants provided informed consent before data collection. Data was compiled from 15 th September 2020 to 30 th November 2020. A convenient sampling procedure was used for the data collection purpose. The initial aspect of the survey comprised of demographic details of the participants. In the second part of the survey, we evaluated the intent to be vaccinated for the COVID-19 with the question, "Do you want to be vaccinated?". The choices were 'yes,' 'no' and 'not sure.' Participants who replied 'no' or 'not sure' were asked one of the following open-ended questions that formed part of the qualitative analysis: 'What makes you reluctant to get the vaccine? "Or "What leaves you uncertain if you're going to have the vaccine?

We performed two rounds of pilot testing of the key concerns determining the intent to be vaccinated in a convenience survey of more than 100 individuals and did not detect any 

Assuming the Pakistan adult Population to be 113,400,000 [11], with a vaccine acceptance of 57% [10] and margin of error 4% (95% CI: 53% -61%), we calculated a minimum sample size of 600 adult individuals to be included in this. However, a total of 1003 participants were included in this survey. Results from this survey were analysed using SPSS Version 24. The descriptive statistics including frequencies and percentages were calculated for general demographics of participants. An independent Kruskal-Wallis test was undertaken to identify if there was significance in participants age and whether they would consider getting the vaccination AChi-Square test was used to compare demographics with participant's intension to be vaccinated or not. Statistical significance was set at ≤0.05 for both the independent Kruskal-Wallis test and Chi-Square tests.

Of the 1003 participants included in this study, 75% of the participants completed survey questionnaire online through a Google form. Only 25% of all participants responded face to face.

The response rate was 80% as some people refused to participate. The mean age of the participants was 29.62 ± 10.47 years. There were a higher percentage of female participants 60.9% (n=611) included in this survey. 57.02% (n=572) of the participants were employed at time of survey. A total of 63.31% (635) participants were college graduate or above in terms of education level and 71.18% (xx) participants belong to urban part of the country. Approximately 70.68% (n=709) of the participants had previous experience of vaccines for any other diseases like flu, hepatitis, polio etc. Only 4.9% (n=49) participants think that they will be seriously ill from corona virus within 6 months and 39% (n=392) participants were confident that they will get corona virus. In this survey, 51.6% (n=519) participants marked their current state of health as "Good". However, only 1.2% (n=12) participants choose "poor" for their current health status.

Further characteristics of study population are presented in Table 1. A total 71.29% of the population reported they would get the vaccine and 10.47% reported they would not get the vaccination. However, 18.24% reported they were unsure if they would get vaccinated or not. Results from a chi-squared when taking gender into consideration showed there was statistical significance with gender and whether the individual would consider being vaccinated (P<0.001). Results from a Chi-squared test showed there was no statistical significance when taking ethnicity, employment status or income into consideration and if individuals would consider vaccinationwith p-values: 0.008, 0.11 and 0.79 respectively. An independent Kruskal-Wallis test showed there was no statistical significance in participants age and whether they would consider getting the vaccination or not (p=0.118).

All participants, who answered no or not sure to the question, "Do you want to be vaccinated", were given the option to specify their reasons. They were asked if you answer "No" (no/not sure), then please specify your reason why you don't want to be vaccinated against COVID-19?

Of the 105 participants who said they would not have the COVID-19 vaccine, 84 decided to provide a reason as to why they would not have the vaccine. Of the 183 participants who said they were not sure if they would have the COVID-19 vaccine, 102 decided to provide a reason as to why they are unsure. The total of 186 participants who provided a reason for not intending to be vaccinated or being unsure as to whether they would be vaccinated referred to anti-vaccine attitudes, beliefs, or emotions.

The main themes for vaccine hesitancy were financial issues, not trusting entities involved in vaccine development, testing, government or dissemination, anti-vaccine attitudes and the safety and efficacy of the vaccine as reported in Table 2 .

Twentyparticipants said they would not have the vaccine due the vaccine being too expensive and unaffordable. Seven of the 20 participants (38.89%) who reported they would not have vaccine due financial issues subsequently reported they would have the vaccine if available to them free of charge.

One participant reported that:

"I am sure that I would not be able to effort a vaccine. But, I will definitely get a vaccine, if it will be free of cost".

With regards to the vaccine safety and efficacy, participants reported they would like to know the effectiveness of the vaccine prior to being inoculated. In addition, participants reported there were no post surveillance vaccine effectiveness reports and they did not want to be test subjects. Our findings demonstrated that over two-thirds of the study participants showed a positive attitude towards being vaccinated against COVID-19, once available. There are ongoing chains of debates in terms of the concept of herd immunity, lockdowns, adhering to social distancing, wearing facemasks and vaccinations to support the reduction of COVID-19 cases and it serious consequences..It is to be understood that only one preventive measure may not be sufficient to counteract this deadly virus on a global scale [13] . Earlier research study has suggested that high preventive self-care islinked with greater control over widespread epidemic [14] . Thus, this perceived susceptibility to the COVID-19 infection can only be infused with knowledge and awareness.

In our current study, 71.29% of the participants showed intent to consider the COVID-19 vaccination. One reason for this high percentage of vaccination intention in our study population could be a result of an increased number of well-educated participants in this study, highlighting the importance of education.

In contrast to our study, areport from a Southeast Asian country, Malaysia, by Wong et al. found vaccination intent of 94.3% [15] . Our findings were in agreement with a study conducted in USAwhich reported 67% vaccination intent [16, 17] . We were unable to draw an inter-country comparison of the COVID-19 vaccine intent, as no such data is currently available in Pakistan at the moment.

In this study, the majority of the participants were interested to know about vaccine safety and efficacy before being inoculated. They would not want to be treated as test subjects or be the victims of adverse effects associated with the COVID-19 vaccine. Therefore, sufficient knowledge and awareness is necessary through evidence based studies [18] . Some of the participants believed that adhering to standard operating procedures such as washing hands, wearing masks and social distancing could provide enough protection against COVID-19.

Moreover, the anti-vaccine attitude was also prevailing among Pakistani population as many people thought that vaccine would not be beneficial as they believe COVID-19 is similar to flu virus, which is rapidly changing its genetic material. Therefore, they stated that vaccine would not be effective in terms of reducing the spread and the severity of infection. These statements are highly suggestive of inadequate knowledge, word of mouth and myths. These inaccurate concepts were further pronounced with changing statements from World Health Organization (WHO) due to evolving situation of the COVID-19. All these above statementsdemand evidenced based education to the general public [18] . India and South Africa showed a high tendency of vaccine acceptance; there was no data available for LMICs in the survey undertaken by Lazarus et al. [19] .

Pakistan is witnessing a great challenge with respect to acceptability of the Polio vaccine and a large number of the population are unable to gain confidence from this phenomena [20] . In consequence, a number of participants believe that COVID-19 is nothing more than a hoax.

Despite this, our results show a positive attitude and low hesitancy towards COVID-19 vaccine.

The present study was not devoid of limitations. These limitations must be categorically mentioned to avoid any misinterpretation of the findings. First and foremost, given the use electronic platform (Google Forms and Emails) for data collection, sampling bias may have occurred and therefore external validity (generalizability) could have been compromised.

Secondly, of note, there is a slight over-representation of females compared to males in this study. This could be owing to circulation of the questionnaire link to the referred members and that may have resulted in selection bias and eventually non-representativeness of the study sample. In addition,, the study may have fallen to self-reporting bias since responses in the questionnaire were based on self-reporting and completed without the presence of a healthcare professional. In such studies, there is a limitation as participants have a preference to account socially acceptable responses. Of note, this study did not outline any other key factors that could have influenced the willingness of participants to vaccinate like booster vaccines, gaps between doses, duration of immunity offered by new vaccine and most importantly financial implications J o u r n a l P r e -p r o o f on thepotential vaccine eligible population. In fact, the issue of availability of vaccine for a country with varying population dynamics, it is presumed impact on population willingness was not asked. Within our study, we did not report the confidence and preference of the study sample in locally or internationally-designed COVID-19 vaccines. In light of the above limitations,, further research is needed to collate the metadata. This data will be pivotal and will guide health policy makers to devise apposite strategies such as public awareness and campaigns to precisely tackle the limited knowledge barrier and myths that could affect the vaccine acceptability and overall vaccination coverage, especially in areas where the virus is highly prevalent. Nonetheless, our findings for the very first time in Pakistan contribute immensely to project the potential willingness and hesitancy towards COVID-19 vaccination stemming from the thought process and understanding of the general public.

This study demonstrated that majority of the participants showed a positive attitude towards considering COVID-19 vaccine. The vaccine has been implemented in Pakistan effective of March 2021. Initially the vaccine is for the vulnerable population like health care providers and geriatric population. Despite the encouraging results from this study, the final vaccine uptake will very much influenced by the efficiency and cost of vaccine given the low-middle income status of country. If the vaccination remains free of charge from the government then there would be a greater uptake and it would be easier for the general population to be vaccinated.

Moreover, awareness with informed knowledge of efficacy and possible adverse effects would be of great added value to boost the real response of the Pakistani population towardsthe COVID-19 vaccination.

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. 

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