key: cord-0730045-bs9mcmy9 authors: Alves Barbosa, Orivaldo; Guimarães Andrade, Talita; de Almeida Sousa, Maria Danielly; Correia, José Walter title: COVID-19 in a Patient with Chronic Lymphocytic Leukaemia with Pseudohypoxemia date: 2020-06-11 journal: Eur J Case Rep Intern Med DOI: 10.12890/2020_001763 sha: 20f1137081343b7abd7d02bc025a2b0c17b1973f doc_id: 730045 cord_uid: bs9mcmy9 Infection with SARS-CoV-2 causes critical disease in approximately 5% of affected patients, particularly the elderly, hypertensive, obese and immunocompromised. Patients with haematological cancer, including chronic lymphocytic leukaemia (CLL), are particularly at risk of complications. Very rarely, patients with extreme leukocytosis may develop spurious hypoxemia, or pseudohypoxemia, which confuses the diagnosis of complications and can lead to intervention errors. We report the case of a patient with CLL, severe infection with SARS-CoV-2 and pseudohypoxemia. LEARNING POINTS: Patients with haematological neoplasms are susceptible to viral, bacterial and fungal infections, and are thus at risk of COVID-19. Patients with chronic lymphocytic leukaemia may rarely, due to a high lymphocyte count, present with spurious, or in vitro, hypoxemia. The clinician must identify and properly treat such cases to prevent any unnecessary treatments and their complications. A novel coronavirus was isolated following a series of viral pneumonia cases in late 2019 in Wuhan, China and notified in January 2020. This new virus, now called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes an acute respiratory illness, coronavirus disease 19 (COVID-19) [1] . There are few data on the risk of developing COVID-19 in people hospitalized with haematological cancers. Most such patients are either given anticancer drugs that suppress bone marrow function or have immune-system cancers, and are at high risk of both community-and hospital-acquired infection. A Chinese survey reported a 10% case rate of COVID-19 in 128 people hospitalized with haematological cancer in Wuhan, higher than that recorded in those with solid cancers (<1%) [2] . Chronic lymphocytic leukaemia (CLL), a mature B-cell neoplasm characterized by progressive accumulation of monoclonal B-lymphocytes, is the most common form of leukaemia in adults. The hallmark of this disease is lymphocytosis in peripheral blood, with various types of cytopenia, immunoglobulin deficiency with recurrent infection, splenomegaly and lymphadenopathy. There are only a few reported cases of SARS-CoV-2 infection in this group of patients. A rare complication in these patients is spurious hypoxemia because of the high number of lymphocytes in vitro with elevated dissolved oxygen consumption in blood samples. Blood gas measurement shows deceptively low blood oxygen pressure (PaO 2 ) levels, with normal oxygen saturation (SaO 2 ). This leads potentially to diagnosis and therapeutic errors, such as needless procedures and oxygen-induced toxicity. We report a rare case of pseudohypoxemia in a patient with COVID-19 and CLL. A patient hospitalised with CLL, which had been diagnosed by flow cytometry in 2015, presented in mid-March 2020 with fever, a sore throat, dry cough and dyspnoea. The dyspnoea worsened after 4 days and the patient was admitted to an isolation room in an intensive care unit due to suspicion of COVID-19. Chest tomography showed bilateral ground-glass opacities with multifocal confluent mosaic attenuation areas, involving much of the lung parenchyma ( Fig. 1) . A nasal swab was positive for SARS-CoV-2 on RT-PCR testing. Due to worsening respiratory symptoms, decreased blood oxygenation and enlargement of the infiltrate on radiology (Fig. 2) , orotracheal intubation was performed and methylprednisolone 60 mg/day, antibiotics (piperacillin+tazobactam 18 g/day, azithromycin 500 mg/day and linezolid 1200 mg/day) and hydroxychloroquine 400 mg/day were administered. Lung protective ventilation was initiated, maintaining a plate pressure of <30 mmHg and a distension pressure of <15 mmHg. At initial admission (16 February 2020), the patient had a body temperature of 38.5°C, white blood cell count of 323×10 9 cells/l, lymphocyte percentage of 96%, haemoglobin of 7.6 g/l, platelet count of 150,000 cells/l, C-reactive protein (high sensitivity test) of 27.75 mg/l and lactate dehydrogenase of 321 U/l. Plasma IgG, IgM and IgA concentrations were markedly reduced (0.312, 0.33 and <0.22 g/l, respectively) and human intravenous immunoglobulin (20 g) was administered once daily for 5 days. After 14 days, the patient had markedly improved regarding oxygen saturation, mechanical ventilation and radiological findings. However, there was a striking dissociation between normal pulse oximetry and persistent low oxygen pressure, prolonging weaning of the patient from mechanical ventilation. We suspected pseudohypoxemia and conducted blood gas analysis at 30% and 100% oxygen fractions, with little difference in PaO 2 (60-80 mmHg), suggesting our diagnostic hypothesis was correct. Consequently, the patient was weaned to an oxygen fraction of 30% and maintained an SpO 2 of 98-100%, with no evidence of low tissue perfusion. COVID-19 is caused by a new type of SARS-CoV-2 coronavirus. The elderly and those with underlying conditions are particularly susceptible to the disease. There are few reported cases in the literature of CLL patients with COVID-19, but it can have a major impact on their illness [3] . Patients with CLL often have humoral and cellular immune defects, with a strong predisposition to recurrent infections, especially bacterial infections. T-cells, which are responsible for the immune response against viral infection, are depleted in patients with CLL, in particular if they have received chemotherapy [4] . These patients may be predisposed to severe infection by SARS-CoV-2, as occurred in our patient. Due to the high risk of COVID-19 infection in patients with CLL, therapy in oligosymptomatic patients should perhaps be delayed as well as in patients with non-life-threatening cytopenias or undergoing less intensive chemotherapy regimens [5] . Pseudohypoxemia is rare and secondary to a high number of metabolically active white blood cells with a high consumption of dissolved oxygen in blood samples. The rate of oxygen consumption by white blood cells is clinically insignificant in most patients with normal blood counts, but in patients with white blood cell counts above 50,000/μl or with severe thrombocytosis, pseudohypoxemia may occur. It is important for clinicians to recognise this condition to avoid diagnostic and therapeutic errors induced by a falsely low oxygen reading [6] . During mechanical ventilation, unrecognized spurious hypoxemia can cause an inappropriate rise in the inspiratory oxygen fraction, thus exposing patients who already are prone to respiratory complications to additional pulmonary oxygen toxicity. A study systematically investigated the magnitude of spurious hypoxemia in 45 patients with acute leukaemia and hyperleukocytosis, and found a poor correlation between SaO 2 and SpO 2 in the presence of a white blood cell count above 100,000 mm 3 , grossly proportional to white blood cell count and time to analysis of blood gases [7] . Our patient demonstrated that a high white blood cell count caused false arterial blood gas measurements of oxygen pressure. Physicians should consider a diagnosis of pseudohypoxemia in patients with white blood cell counts >50,000/μl or severe thrombocytosis, high SpO 2 , very low PaO 2 and no alternative aetiology of hypoxemia. As observed in our patient, pulse oximetry in the context of clinical evidence supporting adequate tissue perfusion may be the most reliable method to assess oxygenation in hyperleukocytosis patients. Early diagnosis of pseudohypoxemia may prevent unnecessary testing and prolonged mechanical ventilation. A novel coronavirus outbreak of global health concern COVID-19 in persons with haematological cancers COVID-19 in a patient with chronic lymphocytic leukaemia Viral infections and their management in patients with chronic lymphocytic leukemia How to manage lymphoid malignancies during novel 2019 coronavirus (CoVid-19) outbreak: a Brazilian task force recommendation Pseudohypoxemia in a patient with chronic lymphocytic leukemia Hypoxemia during extreme hyperleukocytosis: how spurious?