key: cord-0730025-72coz61y authors: Ali, Elrazi; Mohamed, Abdelaziz; Abuodeh, Joud; Albuni, Mhd Kutaiba; Al‐Mannai, Najlaa; Salameh, Sarah; Petkar, Mahir; Habas, Elmukhtar title: SARS‐CoV‐2 and guttate psoriasis: A case report and review of literature date: 2021-07-16 journal: Clin Case Rep DOI: 10.1002/ccr3.4568 sha: 8dae61661ab622691208408af1ea0c31d424a00a doc_id: 730025 cord_uid: 72coz61y Guttate psoriasis is a rare dermatological presentation of SARS‐CoV‐2 infection and is seen mainly in patients with an underlying disease psoriasis. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is an airborne disease with various degrees of severity ranging from asymptomatic to multiorgan failure. It often presents with non-specific symptoms such as fever, headache, and fatigue, accompanied by respiratory symptoms (e.g. cough and dyspnea) and other systemic involvement, including the skin. Several dermatological manifestations were reported to occur with SARS-CoV-2. They include various types of skin rash and worsening of underlying skin disease. However, only a few cases of SARS-CoV-2 infection have been linked to precipitate guttate psoriasis. We report an unusual case of SARS-CoV-2 infection in a 30-year-old lady with no previous medical illness who developed severe psoriasis post-SARS-CoV-2 infection. She responded well to cyclosporine. Psoriasis can be triggered by various infections, including SARS-CoV-2 infection. We are reporting an unusual case of the post-SARS-CoV-2 infection triggering severe psoriasis. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection as a novel coronavirus causes a cluster of pneumonia cases in Wuhan city in China at the end of 2019. The virus causes coronavirus disease 2019 (COVID-19), ranging in severity from mild asymptomatic to fatal disease due to severe acute respiratory distress syndrome and respiratory failure. 1 Hospital admission is more common in the elderly population, and mortality is high among older patients and patients with comorbidities. 2,3 It typically presents with symptoms of fever and upper respiratory symptoms. Non-respiratory presentation of SARS-CoV-2 infection includes gastrointestinal symptoms such as diarrhea, vomiting, and diabetic ketoacidosis. 4, 5 Moreover, SARS-CoV-2 was reported to present as and precipitate heart failure and even fulminant liver failure. 6, 7 Among the various presentation of SARS-CoV-2 infection, the cutaneous manifestations were not uncommon. Psoriasis is an inflammatory skin condition characterized by well-demarcated erythematous plaques with an overlying scale. Commonly, it is a chronic condition, but it may present as an acute eruption in patients with no previous disease or worsening of the chronic rash called guttate psoriasis. We present a young lady with no significant past medical history presented with severe guttate psoriasis after SARS-CoV-2 infection. She developed guttate psoriasis and responded well to treatment. Thirty years female from Nepal with no past medical history presented on March 2021 with a low-grade fever and mild cough. She was diagnosed with SARS-CoV-2 infection using fully automated reverse-transcription polymerase chain reaction (RT-PCR) Cobas ® 6800 (Roche) from nasopharyngeal and throat swabs with CT 15.45. Chest Xray was unremarkable apart from increased bronchovascular marking, and she was classified as mild SARS-CoV-2 disease according to the WHO case definition. 8 She only received vitamin C tablets along with paracetamol during her SARS-CoV-2 infection. She recovered from fever and cough and tested negative 20 days later. Blood investigation is shown in Table 1 . Two days after testing positive for SARS-CoV-2, she noticed a painful scaly rash that progressed to involve most of her skin ( Figure 1 ). The rash was a widespread painful, itchy erythematous skin rash with significant scaling that mainly affects the trunk, the back, upper limbs, and scalp. The rash spares her face, palms, and soles. She first noticed a painless scattered slightly scaly rash with nail changes 6 months ago( Figure 2 ), which she did not seek medical attention. The lesions were stable until the presentation when she noticed a rapid progression of the rash. There were no associated joint pain or swelling; she has no family history of similar conditions, and she did not use any topical creams other than Vaseline. Her vitals showed one episode of Fever spiking to 39 degrees, and blood pressure was on the lower borderline of 100-90 SBP with tachycardia in the range of 90-110 beats per minute. Bodyweight was 45 kg. On examining the patient, scaly, well-demarcated erythematous plaques were noticed over the trunk, limbs, scalp, and ears covering approximately 60% of body surface area. Mouth examination was unremarkable no erythema or congestion. Skin punch biopsy from the abdomen revealed prominent regular acanthosis with elongated rete (psoriasiform hyperplasia), as well as surface hyperkeratosis and parakeratosis. The granular layer was lost. Foci of neutrophilic microabscesses were noted within the stratum corneum (Munro microabscesses). The superficial dermis displayed perivascular predominantly lymphocytic inflammatory infiltrate with scattered neutrophils. Deep dermis was unremarkable. Fungal stain was negative. Histologically, the appearances were in keeping with psoriasis ( Figure 3 ). She was admitted for 5 days during she received generous IV hydration and started on oral Cyclosporine 100 mg twice daily therapy (after SARS-CoV-2 was negative), along with oral minocycline, topical mometasone 1% cream with emollients. The renal function was stable. Her skin rash improved significantly, and she was discharged on cyclosporine and mometasone cream with dermatology follow-up. SARS-CoV-2 is a common infection during the last 18 months. Various presentations are noticed; among these different presentations is the cutaneous manifestation. Dermatological manifestation of SARS-CoV-2 was reported in the case series. Skin involvement in SARS-CoV-2 infection is not uncommon: Approximately 0.2% to 20.4% of SARS-CoV-2 infected patients had skin lesions. 9 The timing of cutaneous manifestations of SARS-CoV-2 is difficult to predict; it was reported at the onset of the illness and event during recovery. 9 There is no clear link between the severity of SARS-CoV-2 and the presence of cutaneous manifestation. 10 Various types of skin rash were reported; the most common was exanthematous (morbilliform) rash. The morbilliform rash predominantly involves the trunk and more frequently reported after hospital discharge or recovery. 9 Other types of skin rash associated with SARS-CoV-2 infection include Pernio (chilblain)-like acral lesions, vesicular (varicella-like) eruptions, urticaria, livedo reticularis-like, and fixed livedo racemosa/retiform purpura. Interestingly, retiform purpura lesions seem to be associated with severe SARS-CoV-2. 11 Psoriasis is not an uncommon skin disease; it has a relatively high prevalence in the general population, estimated to be around 0.6% to 4.8%. 12 The most common form of psoriasis is chronic plaque psoriasis. Guttate psoriasis is a form of psoriasis that presents acutely and is commonly seen in children and young adults under 30, but all age groups can be affected. 13 Typically, guttate psoriasis occurs following acute infections, most commonly streptococcal infection seen in more than 50% of patients. 14 The exact pathophysiology of guttate psoriasis is not well understood. The strong link to streptococcal infection proposed that the underlying mechanism is related to cross-reactivity between streptococcal M-proteins or molecular mimicry. 15 Additional mechanisms include streptococcal super-antigens acting to augment the expression of the skinhoming cutaneous lymphocyte antigen (CLA) on effector T cells, contributing to the migration of T cells into the skin. Addition theory is an innate immune-mediated inflammatory response that occurs as a consequence of the binding of peptidoglycan or other streptococcal antigens to cell receptors. SARS-CoV-2 infection was reported to trigger attacks of psoriasis. However, SARS-CoV-2 infection was rarely reported to trigger guttate psoriasis. A review of the literature showed only one case report who developed guttate psoriasis following SARS-CoV-2. 16 The reported patient 16 had a history of chronic plaque psoriasis, which was not active, and developed the skin rash on day 6 after the fever's onset. The skin lesions were not severe, and the patient was treated with betamethasone 0.025% cream and did not require immunosuppressive medications. Our patient has mild skin changes suggestive of psoriasis, and it was so mild that she did not seek medical evaluation for it. Additionally, there was nail pitting (Figure 2 ) which indicates that the patient had mild chronic plaque psoriasis that was unnoticed and SARS-CoV-2 lead to trigger the flare as guttate psoriasis. The skin rash flared two days after the onset of SARS-CoV-2 and continued to worsen during the recovery from SARS-CoV-2. The respiratory symptoms were mild, the chest X-ray was unremarkable, and she did not develop any thrombotic complications. 17 Despite that, she had severe skin eruption supporting the reported fact that skin rash with SARS-CoV-2 has no relation to the severity of the respiratory symptoms. The SARS-CoV-2 virus may cause the eruption of guttate psoriasis by a similar mechanism to streptococcal infection by molecular mimicry, or the cytokine excess might cause it during the acute infection. 15 Similar findings were observed with other viral infections like 18 SARS-CoV-2 virus is not commonly causing guttate psoriasis compared to other cutaneous manifestations, the reason is mostly related to the genetic predisposition as with psoriasis is known to be higher in people with specific HLA type like HLA-Cw*0602. 19 Furthermore, no cases of guttate psoriasis were reported to occur in patients without pre-existing psoriasis, indicating that the main factor is the genetic predisposition. The patient received cyclosporine with significant improvement in few days ( Figure 1 ); during that time, she was tested negative on RT-PCR. The difficulty in starting treatment in patients with SARS-CoV-2 on immunosuppressive medication is the increased risk of infection and particularly with cyclosporine, which is associated with increased BP, which worsens the outcome from SARS-CoV. 20 In conclusion, SARS-CoV-2 can have various skin manifestations: Of these manifestations, guttate psoriasis is a rare finding. It is seen in patients with the chronic form of psoriasis not reported in patients without previous skin disease. Our patient responded well to cyclosporine therapy, but caution should be taken if the patient is still SARS-CoV-2 positive. The case report was approved by the Medical Research Center with MRC-04-21-358. 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An immunological view of the pathophysiology of psoriasis Clinical course of guttate psoriasis: long-term follow-up study Psoriasis-as an autoimmune disease caused by molecular mimicry Guttate psoriasis secondary to COVID-19 Prevalence of venous thromboembolism in critically Ill COVID-19 patients: systematic review and meta-analysis. Front Cardiovasc Med Respiratory virus infection triggers acute psoriasis flares across different clinical subtypes and genetic backgrounds Comparison of clinical features of HLA-Cw* 0602-positive and-negative psoriasis patients in a Han Chinese population Psoriasis and COVID-19: a narrative review with treatment considerations I would like to thank the Internal Medicine Residency Program, Dr. Ahmed Ali Almohammed, Dr. Dabia Hamad Almohanadi, and Qatar National Library for scientific sup- Written informed consent was obtained from the patient for publication of this case report.