key: cord-0729093-nskjiop0 authors: Cubi-Molla, Patricia; Buxton, Martin; Devlin, Nancy title: Allocating Public Spending Efficiently: Is There a Need for a Better Mechanism to Inform Decisions in the UK and Elsewhere? date: 2021-06-09 journal: Appl Health Econ Health Policy DOI: 10.1007/s40258-021-00648-2 sha: f6e4354eb1c6f8bb6b29daab493aa7feef14cd0a doc_id: 729093 cord_uid: nskjiop0 In the UK few if any regular processes explicitly address comparisons of value for money between spending in different government departments, despite the existence of mechanisms that could in principle achieve that. This leaves a very important gap in evidence and means that decisions about public spending allocations are likely to miss opportunities to improve social welfare from existing budgets. Greater attention to the development of methods and evidence to better inform the allocation of public sector spending between departments is therefore urgently needed. We identify a number of possible approaches to this—some of which are being used in different countries—and highlight their strengths and weaknesses. We propose a new, pragmatic approach that incorporates a generic descriptive system to measure the disparate outcomes produced by public sector activities in a commensurate manner. Discrete-choice experiments could be used to generate evidence of the relative importance placed on different aspects of public sector outcomes by members of the general public. The proposed approach would produce evidence on value for money across departments, and the generation of evidence on public preferences to support that. For several decades, considerable effort has gone into mechanisms to achieve more efficient allocation of funds within specific areas of public spending. Nowhere are those efforts more obvious than in the healthcare sector and its systematic use of cost-effectiveness analysis to assess new healthcare technologies. For example, in England, the National Institute for Health and Care Excellence (NICE) assesses the cost effectiveness of health technologies using evidence on the incremental cost-effectiveness ratio (ICER), expressed in terms of the incremental cost per quality-adjusted life year (QALY) gained. The ICER of new technologies is compared against a cost-effectiveness threshold ratio that is intended Current processes for allocating public spending between departments are not informed by appropriate evidence about trade-offs. Greater public good could potentially be achieved by reallocating existing budgets toward activities with higher value to society. We identify a number of ways of measuring the incremental productivity from potential specific projects/ policy changes at the budgetary margin where decisions are being made, and consider the strengths and limitations of each. We suggest an alternative approach, involving the identification of a core set of generic outcome attributes that could be used to systematically measure and compare the outcomes produced from disparate public sector activities in a commensurate manner. The approach could be accompanied by evidence on the preferences of the general public for different types of public sector outcomes, facilitating comparisons of value for money. Further research in this area has the potential to substantially improve the evidence available to inform the allocation of public sector budgets. public sector activity beyond health not only contributes to the challenges of evaluating multi-sectoral interventions, it is also reflected in the lack of an 'all-encompassing' measure of value to inform assessments of value for money across the public sector. This represents a fundamental weakness of the public sector strategy regarding resource allocation. In this paper we aim to stimulate debate and research efforts to improve the evidence available to inform the political process. In particular our aims are threefold: first, to identify what we consider to be a very important gap in the evidence currently being used to allocate budgets between public sector activities in the UK; second, to provide an overview of the main types of approaches that are available and their limitations; and third, to propose a pragmatic approach that could be taken to the measurement and valuation of disparate public sector outputs in a commensurate manner. Within government departments it appears there is a considerable but variable degree of evaluation of major projects or proposals, some of it undertaken internally and some commissioned externally from academic researchers or consultants. These should follow the methods for economic evaluation as set out in the HM Treasury's 'Green Book' [15] . The Green Book strongly advocates for the quantification of the benefits associated with a new policy. Its preference is that this quantification should be in monetary terms via Social Cost Benefit Analysis (CBA), or, where CBA is not possible, using measures of subjective wellbeing, provided that is appropriate to the context/option under appraisal (e.g., community cohesion). This is intended to ensure consistency in the methods used by different Departments. In practice, undertaking a full CBA is not always possible or practicable, and there is considerable variation in the detailed methods and effort that goes into describing, measuring and valuing the myriad of different benefits that proposals provide, reducing the direct comparability of such evaluations. Table 1 illustrates this result. We extracted information from a selection of published Impact Assessments (IAs) in the following areas: Department for Education (DfE), Department of Health and Social Care (DHSC), Ministry of Justice (MoJ), Department for the Environment, Food and Rural Affairs (DEFRA), and Department for Transport (DfT). We observed a lack of consistency in the methods to represent the opportunity cost of marginal spending in the National Health Service (NHS) [1] . In principle, any proposed new spending with an ICER that is higher than NICE's threshold should not be introduced because it is likely to displace more health benefits than it generates [2, 3] . There are considerable challenges to implementing such assessments, not least in estimating the opportunity cost of NHS spending at the margin [1, [4] [5] [6] [7] . Nevertheless, the concept of the QALY [8] [9] [10] [11] is widely accepted as providing a pragmatic, operational measure of value that facilitates comparisons of cost effectiveness between healthcare interventions [12] . The measurement approach is widely used in health technology appraisal (HTA) systems around the world [13] . The QALY focuses on outcomes achieved in terms of improving survival and quality of life, combining these into a single metric that allows comparisons of effectiveness and cost effectiveness of technologies aimed at different conditions and dissimilar outcomes. This generally works well when interventions are relatively small in comparison with the overall health budget, primarily entail resource use within the healthcare sector, and where the outcomes are exclusively or primarily QALY gains. However, occasionally there is a need to evaluate policies that have major effects across the whole healthcare budget, or where there are strong cross-sectoral elements of costs, outcomes or both. An example is the relationship between the health-and social-care sectors-the importance of which has been recognised by the development of an outcomes measure suitable for use across both sets of services that extends the range of services that can be subject to QALY evaluations [14] . More generally, it has occasionally been argued that benefits beyond QALYs-such as increased productivity of workers-should be considered in assessing health technologies, although it remains unclear how to take into consideration such wider factors without significantly departing from the cost-per-QALY framework. A much broader example of the challenges encountered in evaluation of cross-sectoral costs and effects can be found in the difficulty assessing alternative government responses to COVID-19, where there are complex trade-offs between health and wealth and effects on the socio-demographic, socio-economic and generational distributions of costs and effects. Evaluating options where costs and benefits cross the borders of different areas of the public sector pose challenges in part because other areas of the public sector lack a single measure of output and value equivalent to the QALY, even though the measurement of effects on mortality and to a lesser extent on quality of life has also historically been a research focus in non-health sectors such as transport or environment [12] . This lack of outcome metrics in areas of used by different departments. For example, according to the Green Book, the impacts of government proposals on health should always be considered. However, few IAs in non-health departments quantify the impact on health, and the monetisation of health impacts is not consistent across reports. Different areas in the Government are putting much effort into helping local/area-related authorities make evidencebased spending decisions. For instance, Public Health England (PHE) set up a Prioritisation Framework spreadsheet to help local public health teams' decision making [16] . Other departments designed specific toolkits as guidance to local bodies on how to plan and undertake an impact evaluation (see for instance toolkits created by the Department for Business, Energy and Industrial Strategy or the DfT [17, 18] ). However, toolkits generally work as a guideline and fail to provide an explicit list of output measures to be used in the evaluation: CBA is rarely suggested as the recommended form of evaluation. As a consequence, IAs created using these toolkits are not always directly comparable even within the same department. Public Spending Reviews set spending limits for each government department. Each department is then required to prepare an annual departmental business plan setting out how it will deliver agreed objectives and government manifesto commitments within its spending limit. There appears to be no formal process through which comparisons are made across departments in terms of the value of, and priorities between, specific additional spending proposals. In a review carried out by the UK government in 2015 [29] , lack of comprehensive and comparable evidence, as well as difficulties in the measurement of outcomes, were highlighted as some of the main complications of comparing value for money across departments. Recommended actions included the use of multiple outcome measures [30] . A recent review commissioned by the Treasury proposed a Public Value Assessment Process Framework (based on the work of Mark H. Moore defining 'Public value' [31] and 'Public value account' [32] ). However, it largely fails to address the process by which budget allocations are made between departments, and whilst it highlights the need to engage users and citizens, it talks of the need to convince taxpayers of the value being delivered by spending rather than any process that might seek out and incorporate the values of the public to improve the allocative efficiency of the prioritisation process. In structured discussions we undertook with those familiar with the processes, all agreed that few if any procedures, formal or informal, explicitly addressed comparisons of value for money between departments. (See in Attempts to assess and compare value for money across disparate sectors is a challenge, and any rationale underlying a general framework is debatable [33] . The most common approach describes the aim of the decision maker to be the efficient inter-area allocation of a budget, achieved by measuring net benefits (welfare) in order to establish critical cost-benefit ratios [34] . This goal might not be completely unconstrained-for example, it might be subject to some equity or distributional constraints. Whatever the goal of public spending is, we would argue that decisions about allocating public sector budgets are being made anyway, in the absence of evidence, and that improving the evidence base for such decisions would assist by promoting debate and explicit consideration about what the goals of public spending are. There is a disparate literature on this issue, which includes a range of theoretical approaches to this problem and examples of elements of these being operationalised. Most approaches seem to fit within three broad types, as characterised in Fig. 1 . The first approach assesses value for money by establishing the trade-off between sector-specific outcomes (see framework A in Fig. 1 ). The main advantage of this option is that decisions would be informed by sector-specific aggregate measures, which are in turn those measures that better capture the levels of efficiency within a department (such as QALYs for HTA [3] , or Prevented Fatalities for road safety). This approach is probably the most idealistic one, and arguably something to aspire toward. However, this option would constitute a very ambitious and extensive research agenda at present, given that the development and use of QALYs as a health-specific aggregate measure has not been mirrored in other public sector departments. This approach does not therefore provide a pragmatic means of proceeding in the short to medium term. A second approach would require the use of a single measure for depicting policy impacts (see framework B in Fig. 1 ). The most widely used measures are direct (monetary outcomes) or indirect (subjective wellbeing). An example of the direct monetisation of policy impacts and costs is provided by the UK (see Box 1) . This method Table 1 , that in many cases the important intangible outcomes are extremely difficult to value directly, and the danger is that the focus is transferred from the important outcomes to those that can most easily be monetised. In fact, recent research has proved that even similar outcomes (such as 'health' or 'human life') are given inconsistent monetary valuation in different government departments [35] . Our review of IAs demonstrates that in practice it is too difficult to put monetary values directly on many of the key outcomes. This suggests that the current approach, despite being consistent with (and indeed advocated by) the Green Book, is in practice problematic and as a result provides inadequate evidence to ensure that decisions about public sector spending are efficient. The UK's Green Book guidance, which is updated periodically and is firmly grounded on the principles of welfare economics, applies to all government departments as well as public bodies. The appraisal of a new policy intervention is based on Cost-Benefit Analysis, where relevant costs and benefits for UK society overall are valued and "monetised where possible in order to provide a common metric" (paragraph 2.12). The monetisation uses market prices as a reference, but alternative valuation techniques (such as revealed or stated preferences, or wellbeing measures) or specific standard values can be used when market rates are lacking or are inadequate. A second method is to measure the impact of every policy in terms of subjective wellbeing (SWB) [36] . There has been considerable interest in the use of SWB approaches by previous governments as an alternative or complement to Gross Domestic Product (GDP) [37] , and there are strong academic advocates for the use of SWB to evaluate policy [36] . The UK's Office of National Statistics now includes four 'standardised' questions on SWB into national surveys. Measuring outcomes in terms of wellbeing would in principle facilitate direct comparison of outcomes between departments. However, to date, SWB has rarely been used as the principal output measure directly linked to specific decision making. Whilst there are strong theoretical foundations for SWB, there are unresolved issues with the measurement properties of the questions used to measure it [38] . The main drawback of this approach is the lack of consensus about whether any measure of wellbeing could be sufficiently robust, reliable and comprehensive, and yet sensitive to relatively small changes in overall wellbeing, to capture the value of diverse policies across the public sector. Whilst this method may be useful as a tool to assess ex post the effect of substantial policy programmes, we are not aware of any examples of it being successfully used to evaluate ex ante the perceived value of specific policies and programmes. An example of the existing use of SWB can be found in Bhutan (see Box 2). The term "Gross National Happiness" (GNH) index was coined in Bhutan. The GNH index comprises nine domains: psychological wellbeing, time use, community vitality, cultural diversity, ecological resilience, living standard, health, education, and good governance. All domains are equally weighted and are split into 124 variables (in total). New policies are aimed at increasing the GNH index in two possible ways: either increasing the percentage of people who are happy, or improving the living conditions of the "not-yet-happy" part of the population (different thresholds separate both groups). Source: adopted from [35] A third approach is the categorisation of the various outcomes in each case into principal 'outcome types' (see framework C in Fig. 1 ). This method usually relies on predetermined schedules of monetary values (and thus this approach could be seen as the direct monetisation of policy impacts). Examples of this mechanism can be found in the development and use of 'social value banks' in Australia and New Zealand (see Box 3). 1 The NZ Treasury released the cost-benefit analysis crossdepartmental (CBAx) [42] tool in October 2015, with the aim of helping decision makers to compare different options and monetise policy impacts. The CBAx is also used by the Treasury in assessing wellbeing in NZ and developing value for money advice. CBAx contains an 'impacts database' with a list of policy outcomes and a monetary valuation of those. Each policy outcome is categorised into one of 12 'wellbeing domains', based on the domains used by the OECD "better life index" [43] . These domains are: civic engagement and governance; cultural identity; environment; health; housing; income and consumption; jobs and earnings; knowledge and skills; safety; social connections; subjective wellbeing; and time use. The list is open (different users can add new outcomes to the list as long as these are valued in monetary terms). The CBAx impacts database includes outcomes types whose monetary value has been derived through the impact of those outcomes on wellbeing (e.g., gaining a friend or living in a cold house). These wellbeing valuations have been obtained from the Australian Social Value Bank (released in 2016) through a purchased license [44] . Measuring outcomes in a common unit of wellbeing or money would provide the relative value of all of the outcomes. Theoretically, the three methods reviewed in this section would ultimately result in similar 'exchange rates' between public sector outcomes in terms of wellbeing, implying a similar equilibrium for the optimisation process. In practice, limitations of the methods for direct or indirect monetisation and for measuring SWB, and their application, are likely to lead to different conclusions. Given the drawbacks of both direct monetisation and measures of SWB, the indirect monetisation of outcomes (see framework C in Fig. 1) is arguably a more pragmatic approach. However, the specification of the principal outcomes is a complex task, and if these attributes are defined de novo for each individual project, then comparability may be undermined by a lack of transparency and consistency between projects. We propose an alternative approach for assessing public sector outcomes in the UK, in which (a) the outcomes of each policy would be systematically measured using a standardised, pre-defined set of 'outcome types' or attributes to describe the changes resulting from each proposed public policy/good or service; and (b) that facilitates the use of stated preference studies, such as Discrete Choice Experiments (DCEs) [45] to specify the relative weight attached to the achievement of disparate outcomes. DCEs provide a means of identifying the extent to which respondents are willing to trade off an improvement in one attribute (outcome type) against a worsening in another, as a means of identifying the relative value attached to the achievement of different types of outcomes [46] [47] [48] . There is a growing literature on the use of DCEs to generate evidence for public policy [49] , but it tends to be restricted to the one-off evaluation of specific policies. The approach we propose aims to bridge the gap between the direct and indirect monetisation methods, and it may get us closer to the ideal scenario of a political context informed by people's preferences over public wellbeing aspects. The literature provides some indicators of UK societal preferences. For instance, in the UK, health (55%) and education (22%) were chosen as the highest priority for government spending in 2016 by respondents to the British Social Attitudes Survey. However, as highlighted in a report by PHE [16] , new education policies are likely to involve health-related outcomes (e.g., awareness of bad health habits), and new health technologies may also have an impact on education (e.g., pain relief treatments impacting on higher achievements). Therefore, considering attributes that are meaningful across sectors will be of key importance. The feasibility of providing a structured way of measuring public sector outcomes is reinforced by the existence of other outcomes frameworks-for example, the Australian National Development Index, 2 or the Canadian Index of Wellbeing 3 -aimed at providing a complete picture of national wellbeing. Such initiatives, which are part of the wider movement to go beyond GDP [50] , could provide highly relevant inputs to the development of a measure of public sector outcomes. Ultimately, however, a public sector outcomes measure should reflect the attributes of key importance to the taxpayers in the country whose decisions its use may inform. Data extraction from published IAs provided a list of outcomes associated with the UK policy options under consideration. If it were possible to categorise all the outcomes in a set of common attributes, these could then be used systematically to describe, measure, and value, in a commensurate way, the principal outcomes of any governmental activity across departments, whether that activity may be the regulation, funding or provision of goods and services. Table 2 shows the type of attributes found in existing IAs that might provide a starting point for developing a common set of attributes, and examples of policies, in and outside of the NHS, whose outcomes can (in part) be captured by that attribute. Research would be required to develop our suggested approach. First, a systematic review is required to yield a complete list of public services at the margin across different areas of the public sector, characterised in terms of their costs, outputs and outcomes, expressed in as tangible and meaningful a sense as possible. Second, the key attributes of public sector outcomes would need to be extracted from the outcome list. These would form the basis for a generic descriptive system for public sector outcomes, where each attribute is able to be measured in quantitative terms-either on a cardinal scale (e.g., mortality rates) or categorically (high, medium, low) in order to clearly describe the extent of the achievement of that outcome, and changes to outcomes that result from policy options under consideration. These outcome categories could then form the basis for a DCE design, which will seek to elicit the stated preferences of a large sample of the general public with respect to sets of these outcomes. An illustrative example is provided in Fig. 2 . There is an obvious analogy between the proposed approach to measuring and valuing public sector outcomes, and approaches widely used to measure and value attributes of health-related quality of life, such as the EQ-5D, in the healthcare sector [51] . The use of stated preference methods to obtain the values of the general public for generic measure of outcomes has, in that context, been shown to be feasible and to provide a robust and acceptable evidence base for public decisions. The DCE would identify the relative values of the public (or subgroups of beneficiaries of governmental activities) for different types of outcomes and the trade-offs they are willing to make. This could help to inform judgements about value for money across the public sector and this in turn would enable establishment of the marginal value placed on outcomes from different areas of government spending. We recognise of course that assessing budget proposals only based on their expected impact on wellbeing, with the impact measurement reflecting the preferences of the taxpayers, is an ambitious project. Government budget allocation decisions will correctly remain a political decision, which will reflect a variety of considerations and judgements that will go beyond even the broad set of outcomes that would form the basis of our approach; even when developed fully it would be a decision aid to inform and illuminate a complex process. Beyond budget allocations, the generic descriptive system for public sector outputs suggested in this paper could be a valuable tool to inform decision making in any setting that involves the comparison of value for money of interventions whose outcomes have an impact in multiple sectors. A good example of this context is provided by Walker et al. [52] , who propose an extension on the standard 'impact inventory' in health and medicine [53] with the aim of capturing the effects of the intervention in sectors beyond health. A set of attributes representing what is most relevant for the society, such as proposed in this paper, could provide the key dimensions to comprise the impact inventory. In addition, the use of DCE to elicit the relative values of the public for the different attributes could produce a composite measure of value for money across departments, resolving the problems of aggregation related to the impact inventory expansion [54] . The current absence of a formal method to inform the allocation of budgets between departments through public valuation is an important gap in the budgetary allocation methods in the UK. Such a mechanism would be particularly valuable where policies have multiple outcomes that go beyond the main focus of the department in question. In addition, there is considerable interest internationally in methods for capturing benefits other than health gain in the evaluation of new healthcare technologies (e.g., see special ISPOR task force report on US Value Assessment Frameworks [54] ). Whilst there are clearly methods employed to attempt to ensure that, within areas of spending such as health, opportunity costs are identified and considered, there seems little formal consideration in the UK of the opportunity cost at the margin across departments. As no doubt is also the case in many other countries, departmental budgets depend largely on the previous year's budget allocation, adjusted according to broad politically determined priorities rather than on explicit mechanisms that are aimed to achieve allocative efficiency of public spending. However difficult, there is a real need for methods that can provide well-founded comparisons of value for money across departments. This paper has identified a number of possible approaches being tried in different countries. We suggest a way forward for further research to develop a sound yet pragmatic approach for identifying and describing the outcomes from disparate public sector activities in a broad and consistent manner that facilitates making comparisons of public valuations of projects. In the absence of systematic evidence of this kind, it is unclear whether UK taxpayers' resources are being used in a manner that is allocatively efficient. It is potentially the case that the welfare of UK people could be substantially increased without an increase in spending, simply by reallocating budgets toward those activities and policies that produce more of the outcomes that the general public value. The lack of such evidence, or any mechanism to achieve that end, seems like an important wasted opportunity. Searching for a threshold, not setting one: the role of the National Institute for Health and Clinical Excellence Methods for the estimation of the National Institute for Health and Care Excellence cost-effectiveness threshold Estimating the marginal productivity of the English National Health Service from Does NICE have a cost-effectiveness threshold and what other factors influence its decisions? A binary choice analysis Local health care expenditure plans and their opportunity costs The impact of NHS expenditure on health outcomes in England: alternative approaches to identification in all-cause and disease specific models of mortality Issues Surrounding the Estimation of the Opportunity Cost of Adopting a New Health Care Technology: Areas For Further Research Putting the 'Q' in QALYs Economics of coronary artery bypass grafting The NICE cost-effectiveness threshold: what it is and what that means Patient-reported outcome measures in the NHS: new methods for analysing and reporting EQ-5D data Quantifying life: understanding the history of quality-adjusted life-years (QALYs) Are cost-effectiveness thresholds fit for purpose for real-world decision making? Criteria for item selection for a preference-based measure for use in economic evaluation The green book: Central Government guidance on appraisal and evaluation The prioritisation framework: making the most of your budget the-prior itisa tion-frame work-making-the-most-of-your-budget Affordable warmth and health impact evaluation toolkit Department for Transport. Economic insights and social impacts toolkits EMA replacement scheme: 16-19 Bursaries and associated transitional arrangements Evaluation of breakfast clubs in schools with high levels of deprivation Department of Health. Impact assessment-improving outcomes: a strategy for cancer Health impact analysis: shortlisted schemes for airports national policy statement Impact assessment: call out of members of the reserve forces for urgent work of national importance (MOD 0002 Extending permitted development rights for mobile connectivity in England: technical consultation. Validation impact assessment Exten ding_ permi tted_ devel opment_ rights_ for_ mobile_ conne ctivi ty_ in_ Engla nd_-_ Techn ical_ consu ltati on_-_ Impact_ asses sment Impact assessment: the network and information systems regulation 2018 (RPC-4066(2)-DCMS) [Internet] Public Sector Productivity: Measurement Challenges, Performance Information and Prospects for Improvement Challenges in the measurement of public sector productivity in OECD countries Creating public value: strategic management in Government Recognizing public value Modelling the monetary value of a QALY: a new approach based on UK data Critical ratios and efficient allocation Resource allocation in public sector programmes: does the value of a life differ between governmental departments? Measuring subjective wellbeing for public policy: recommendations on measures A study of the relationship between health and subjective well-being in Parkinson's disease patients A short guide to Gross National Happiness Index Public sector efficiency: the roles of political and budgetary institutions, fiscal capacity, and democratic participation CBAx Tool User Guidance: guide for departments and agencies using Treasury's CBAx tool for cost benefit analysis CBAx Spreadsheet Model OECD Better Life Index Australian Social Value Bank Stated choice methods by 74043 20813 0BA57 E9E32 8EAFD CA Deriving welfare measures from discrete choice experiments: inconsistency between current methods and random utility and welfare theory Use of discrete choice experiments to elicit preferences Estimating the monetary value of health care: lessons from environmental economics Discrete choice experiments in health economics: a review of the literature The BRAINPOoL Project Final Report: beyond GDP-from measurement to politics and policy Methods for the economic evaluation of health care programmes Striving for a societal perspective: a framework for economic evaluations when costs and effects fall on multiple sectors and decision makers Recommendations for conduct, methodological practices, and reporting of cost-effectiveness analyses: second panel on cost-effectiveness in health and medicine A health economics approach to US value assessment frameworks-summary and recommendations of the ISPOR special task force We would like to thank (in alphabetic order): Jack Britton, Catherine Connolly, Bronwyn Croxson, Brian Ferguson, Jacque Mallender, Chris Mullin, Luke Sibieta, Clive Smee, Lotte Steuten, and four further anonymous experts, for their valuable insights. However, the views expressed are those of the authors alone. Funding The project is funded by a research grant from the Association of the British Pharmaceutical Industry.Conflict of interest PCM is an employee of the Office of Health Economics, a registered charity, which receives funding from a variety of sources, including the Association of the British Pharmaceutical Industry. MB and ND have no conflicts of interest to report. Views expressed in the paper are those of the authors.Author contributions ND and MB conceived the study. All authors contributed to the study design, interviews and analysis. Data collection was led by PCM, with input from ND and MB. The first draft of the manuscript was written by PCM. All authors worked on previous versions of the manuscript. All authors read and approved the final manuscript.Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by-nc/4. 0/.