key: cord-0727515-kqedq6sx
authors: Fu, Q.; Wu, W.; Liu, Y.; Huang, H.; Zhang, P.; Li, X.; Zhang, L.; Yang, H.; Zhang, X.; Zhang, Q.; Huang, C.
title: Epidemiological, Clinical Characteristics and Risk Factors for Severe Condition and ICU Admission of COVID-19 Patients of Early Stage in China: A review
date: 2021-02-17
journal: nan
DOI: 10.1101/2021.02.15.21249676
sha: 85ca283a7c41dfc418a08219556c5b32378942ed
doc_id: 727515
cord_uid: kqedq6sx

Objective: Some retrospective studies reporting epidemiological, clinical characteristics of COVID-19 patients of early stage were published. We aim to provide an overview of epidemiological and clinical characteristics of the COVID-19 patients, and identification, treatment of early stage, especially for the patients with poor prognosis. Data Sources: PubMed, CNKI and Google Scholar. Study Selection: We searched for published retrospective studies that described epidemiological and clinical characteristics of confirmed COVID-19 patients in China by April 14th, 2020 with search terms. Some studies were excluded according to criteria. Finally, 53 studies were included. Data Extraction: Characteristics of the COVID-19 patients available from included articles were extracted, reorganized and recorded into electronic data forms. Data Synthesis: Characteristics of patients in the included studies were summarized and analyzed for median-interquartile ranges and univariable odds ratio. Conclusion: This study summarized, analyzed and compared epidemiological, clinical characteristics and estimated univariable risk factors among confirmed COVID-19 patients either in former epicenter, in severe condition, with ICU admission or not of early stage. Higher proportions of patients were found to have older age and more comorbidities, typical characteristics on admission and complications either in former epicenter, with severe condition or ICU admission. No evidence showed that patients who were male or had smoking history had higher susceptibility, but they were significant risk factors for severe condition. Some self-implementable traditional Chinese medicine therapies conducted for immunity improvement, control of comorbidities and reduction of some medicine intake. Limited evidence revealed that some characteristics of the disease might be changing with human-to-human transmission, and more research, especially international collaboration, is needed.

including ARDS (p<0.05), acute cardiac injury, other acute respiratory injury, acute 3 kidney injury and shock, were reported in the patients in former epicenter. On admission, 4 most radiological and laboratory abnormalities were found in more patients in former 5 epicenter, including significantly (p<0.05) higher proportions of bilateral involvement 6 (chest radiological examination), white blood cell count > 10 × 10⁹/L, lactate 7 dehydrogenase > 240-250 U/L, C-reactive protein > 3-6 mg/L and C-reactive protein > 8 8-10 mg/L (Table S1 ). Invasive/non-invasive mechanical ventilation and ICU care were 9 applied to higher proportions of the patients in former epicenter significantly (p<0.05). is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint middle-aged and older male, with more cases of older people in former epicenter.

Proportions of the male patients in our study were higher than the male population in is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint

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the newly identified coronavirus may boost cross-species transmission from snake to human. J Med 25 . CC-BY-NC 4.0 International license It is made available under a perpetuity.

is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint is the author/funder, who has granted medRxiv a license to display the preprint in (which was not certified by peer review) preprint

The copyright holder for this this version posted February 17, 2021. ;

Outbreak of pneumonia of unknown etiology in Wuhan China: the 21 mystery and the miracle