key: cord-0726615-rja2ages authors: Berná‐Rico, Emilio de Dios; Álvarez‐Pinheiro, Claudia; Burgos‐Blasco, Patricia; Selda‐Enríquez, Gerald; Azcárraga‐Llobet, Carlos; Fernández‐Guarino, Montserrat; Fernández‐Nieto, Diego title: A Gianotti‐Crosti‐like eruption in the setting of SARS‐CoV‐2 infection date: 2021-08-04 journal: Dermatol Ther DOI: 10.1111/dth.15071 sha: 77ae727ad5156077490e606870d8c614790b1a4e doc_id: 726615 cord_uid: rja2ages nan The patient was discharged with oral paracetamol. However, 2 days later she contacted with our department. The fever and the diarrhea had disappeared, but the rash persisted beyond it and had extended symmetrically to her arms, knees, and feet, with papules coalescing into plaques. Due to isolation measures, a teledermatology consultation was performed ( Figure 1B-D) , and a one-week course of methylprednisolone cream was prescribed. The buttocks and proximal thighs were also affected during the next day. Hand, foot, and knee papules progressively resolved in 11 days, along with RT-PCR negativization, Due to the lack of histopathological data and monomorphism in certain locations, we could not establish a definitive diagnosis of Gianotti-Crosti syndrome (GCS). 6 However, given the parainfectious setting and the course, morphology and distribution of the lesions, we consider it was the most probable diagnosis in our patient. Assuming these limitations, the patient was finally diagnosed with a Gianotti-Crosti-like eruption. GCS is a relatively common dermatosis during childhood, primarily affecting children between 3 months and 15 years of age. Conversely, its appearance in adults is much rarer, with few cases reported in the literature. Regarding its etiopathogenesis, viral infections seems to be the main cause of this syndrome, with EBV being the most common causative agent. However, the spectrum of associated infectious agents in GCS is not completely identified. In some cases, the causal agent remains unknown even after a complete study. 7 The first authors who reported an association between GCS and COVID-19 were Brin et al. 8 In their case, the rash appeared 3 weeks after the beginning of the symptoms. In ours, conversely, the onset of the eruption coincided with the initial peak of fever. Its morphology Cutaneous manifestations in COVID-19: a first perspective Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases Cutaneous manifestations in patients with COVID-19: a preliminary review of an emerging issue Maculopapular eruptions associated to COVID-19: a subanalysis of the COVID-Piel study Clinical and histological characterization of vesicular COVID-19 rashes: a prospective study in a tertiary care hospital The diagnostic criteria of pityriasis rosea and Gianotti-Crosti syndrome -a protocol to establish diagnostic criteria of skin diseases Gianotti-Crosti syndrome An isolated peculiar Gianotti-Crosti rash in the course of a COVID-19 episode. Acta Derm Venereol Teledermatology for COVID-19 cutaneous lesions: substitute or supplement?