key: cord-0725643-78lcesey
authors: Ferrari, Davide; Clementi, Nicola; Mancini, Nicasio; Locatelli, Massimo
title: SARS-CoV-2 infection despite high levels of vaccine-induced anti-RBD antibodies: a study on 1110 healthcare professionals from a northern Italian university hospital
date: 2021-10-29
journal: Clin Microbiol Infect
DOI: 10.1016/j.cmi.2021.10.010
sha: c2073517e0d7a10a75631c1450107117714b5707
doc_id: 725643
cord_uid: 78lcesey

nan

To the Editor, 27 SARS-CoV-2 vaccination campaigns are at an advanced stage in many countries, yet little concerns 28 raised about some cases of post-vaccination infection (1). Thus, real world data are needed to guide 29 health policy makers especially now that the implementation of a third dose administration protocol 30 is being discussed.

Thanks to a longitudinal study (Covidiagnostix), funded by the Italian Ministry of Health, we Intervals are calculated from the day of the 2 nd dose to the day of the first positive RT-PCR test. c Time length of negativization was calculated from the day of the first positive RT-PCR test to the day of the first negative RT-PCR test. d COVID-19 was asymptomatic and the HCPs found out about the infection only through the serological test at T3 e Positivity was discovered by an occasional anti-N test performed at T1 f "Close contacts" refers to the presence of a SARS-CoV-2 positive unvaccinated household at the time of infection

Phase I/II study 106 of COVID-19 RNA vaccine BNT162b1 in adults