key: cord-0724877-2o3agh35
authors: Xiong, Xiaoli; Chua, Gilbert T.; Chi, Shuiqing; Kwan, Mike Yat Wah; Wong, Wilfred Hing Sang; Zhou, Aifen; Shek, Chi Chiu; Tung, Keith T.S.; Qin, Huan; Wong, Rosa S.; Li, Xue; Chen, Peng; Li, Shuai; Chui, Celine S.; Tso, Winnie W.Y.; Ho, Marco H.K.; Wong, Ian C.K.; Chan, Godfrey C.F.; Lau, Yu Lung; Wong, Kenneth K.Y.; Chung, Patrick H.Y.; Li, Hui; Tam, Paul K.H.; Tang, Shao-Tao; lp, Patrick
title: Haematological and Immunological Data of Chinese Children Infected with Coronavirus Disease 2019
date: 2020-06-30
journal: Data Brief
DOI: 10.1016/j.dib.2020.105953
sha: d9535af8a8c374ff341667d01acc39c6edb25bd0
doc_id: 724877
cord_uid: 2o3agh35

Haematological and immunological data of children with COVID-19 infection is lacking. Between 21(st) January and 20(th) March 2020, 244 children who were confirmed to have COVID-19 infection and admitted to the Wuhan Children's Hospital, China were retrospectively reviewed. 193 children were considered as symptomatic, which was defined as having either the presence of clinical symptoms or the presence of CT thorax abnormalities. Their haematological and immunological profiles, including complete blood counts, lymphocyte subsets (T, B and NK cell counts), immunoglobulin (Ig) profiles (IgG, IgA and IgM) and cytokine profiles were analysed and compared between the symptomatic and asymptomatic groups. The median values and the interquartile ranges were calculated. Comparison was made using the Mann–Whitney U test. Children with symptomatic COVID-19 infection had significantly lower haemoglobin levels, but higher absolute lymphocyte and monocyte counts, IgG and IgA levels, as well as interleukin 6 (IL-6), IL-10, tumour necrosis factor alpha and interferon gamma levels. The obtained data will be utilized for further studies in comparing children and adults with COVID-19 infections in other parts of the world and with different severity.

Children with COVID-19 infection confirmed by nasopharyngeal aspirate (NPA) SARS-CoV-2 reversetranscriptase polymerase chain reaction (RT-PCR) were admitted to the Wuhan Children's Hospital between 21 st January and 20 th March 2020. Laboratory data were retrospectively retrieved from the patients' hospital record. The age and gender, as well as their haematological and immunological profiles were recorded (supplementary file), including their complete blood counts (total white cell count, haemoglobin concentration, platelet counts, absolute neutrophil, lymphocyte and monocyte counts), lymphocyte subset profiles (total CD3 T cell count, CD3CD4 helper T cell count, CD3CD8 cytotoxic T cell count, CD19 B cell count and CD16CD56 natural killer cell count), immunoglobulin profiles (IgG, IgA and IgM) and cytokine profiles (interleukin 2 (IL-2), IL-4. IL-6, IL-10, tumour necrosis factor alpha and interferon gamma levels). Table 1 compared the haematological and immunological profiles between children with symptomatic and asymptomatic COVID-19 infection. Children with symptomatic COVID-19 infection had significantly lower haemoglobin levels, but higher absolute lymphocyte and monocyte counts, IgG and IgA levels, as well as interleukin 6 (IL-6), IL-10, tumour necrosis factor alpha and interferon gamma levels.

Data were analysed using Microsoft Excel® (Redmond, Washington, USA) and GraphPad® Prism 8 (San Diego, California, USA). The median values and interquartile ranges were calculated. For comparison of data between the symptomatic and asymptomatic groups, the Mann-Whitney U test was used for continuous variables. A p-value of <0.05 is considered as statistically significant.

This study is approved by the Research Ethics Board of the Wuhan Children's Hospital (Reference number: WHCH 2020022). 

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We thank all the staff members of the Wuhan Children's Hospital for their dedication in caring for sick children, which can be a very difficult time for both patients and their families.

The authors declare that they have no known competing financial interests or personal relationships which have, or could be perceived to have, influenced the work reported in this article.