key: cord-0724815-96powfoi
authors: Park, Bo Eun; Lee, Jang Hoon; Park, Hyuk Kyoon; Kim, Hong Nyun; Jang, Se Yong; Bae, Myung Hwan; Yang, Dong Heon; Park, Hun Sik; Cho, Yongkeun; Lee, Bong Yul; Nam, Chang Wook; Lee, Jin Bae; Kim, Ung; Chae, Shung Chull
title: Impact of Cardiovascular Risk Factors and Cardiovascular Diseases on Outcomes in Patients Hospitalized with COVID-19 in Daegu Metropolitan City
date: 2020-12-29
journal: J Korean Med Sci
DOI: 10.3346/jkms.2021.36.e15
sha: 6ed2c09566e4cb0c6aaff8a1c5d827fa481528d0
doc_id: 724815
cord_uid: 96powfoi

BACKGROUND: Data regarding the association between preexisting cardiovascular risk factors (CVRFs) and cardiovascular diseases (CVDs) and the outcomes of patients requiring hospitalization for coronavirus disease 2019 (COVID-19) are limited. Therefore, the aim of this study was to investigate the impact of preexisting CVRFs or CVDs on the outcomes of patients with COVID-19 hospitalized in a Korean healthcare system. METHODS: Patients with COVID-19 admitted to 10 hospitals in Daegu Metropolitan City, Korea, were examined. All sequentially hospitalized patients between February 15, 2020, and April 24, 2020, were enrolled in this study. All patients were confirmed to have COVID-19 based on the positive results on the polymerase chain reaction testing of nasopharyngeal samples. Clinical outcomes during hospitalization, such as requiring intensive care and invasive mechanical ventilation (MV) and death, were evaluated. Moreover, data on baseline comorbidities such as a history of diabetes, hypertension, dyslipidemia, current smoking, heart failure, coronary artery disease, cerebrovascular accidents, and other chronic cardiac diseases were obtained. RESULTS: Of all the patients enrolled, 954 (42.0%) had preexisting CVRFs or CVDs. Among the CVRFs, the most common were hypertension (28.8%) and diabetes mellitus (17.0%). The prevalence rates of preexisting CVRFs or CVDs increased with age (P < 0.001). The number of patients requiring intensive care (P < 0.001) and invasive MV (P < 0.001) increased with age. The in-hospital death rate increased with age (P < 0.001). Patients requiring intensive care (5.3% vs. 1.6%; P < 0.001) and invasive MV (4.3% vs. 1.7%; P < 0.001) were significantly greater in patients with preexisting CVRFs or CVDs. In-hospital mortality (12.9% vs. 3.1%; P < 0.001) was significantly higher in patients with preexisting CVRFs or CVDs. Among the CVRFs, diabetes mellitus and hypertension were associated with increased requirement of intensive care and invasive MV and in-hospital death. Among the known CVDs, coronary artery disease and congestive heart failure were associated with invasive MV and in-hospital death. In multivariate analysis, preexisting CVRFs or CVDs (odds ratio [OR], 1.79; 95% confidence interval [CI], 1.07–3.01; P = 0.027) were independent predictors of in-hospital death after adjusting for confounding variables. Among individual preexisting CVRF or CVD components, diabetes mellitus (OR, 2.43; 95% CI, 1.51–3.90; P < 0.001) and congestive heart failure (OR, 2.43; 95% CI, 1.06–5.87; P = 0.049) were independent predictors of in-hospital death. CONCLUSION: Based on the findings of this study, the patients with confirmed COVID-19 with preexisting CVRFs or CVDs had worse clinical outcomes. Caution is required in dealing with these patients at triage.

Since the first report of coronavirus disease 2019 in Hubei Province, China, in December 2019, it has been spreading rapidly worldwide, and the World Health Organization had declared the disease a pandemic on March 11, 2020. 1, 2 Studies on a small sample of patients with COVID-19 in China reported that preexisting cardiovascular risk factors (CVRFs) or cardiovascular diseases (CVDs) increase the risk of COVID-19. 2 -6 However, studies on a large sample of patients with COVID-19 in China presented that the prevalence rate of preexisting CVRFs or CVDs in patients with COVID-19 is not higher than those in the general population. 7 -9 Therefore, it remains unclear whether CVRFs or known CVDs are causally linked to COVID-19. 10 -12 Furthermore, it is uncertain whether patients with preexisting CVRFs or CVDs are more likely to progress to severe disease requiring intensive care and invasive mechanical ventilation (MV). Moreover, although several studies have reported on the association between preexisting CVRFs or CVDs and mortality, 2 -7 a comprehensive analysis considering the demographic characteristics, initial presentation, and multiple comorbidities has not yet been conducted. Therefore, this study investigated the impact of preexisting CVRFs or CVDs on the outcomes of patients with COVID-19 hospitalized in a Korean healthcare system.

The Daegu COVID-19 Research Project is an observational multicenter registry of patients with COVID-19 hospitalized in a Korean healthcare system in Daegu City. All data about the patients and management details were obtained at each hospital.

Between February 15, 2020, and April 24, 2020, 2,269 consecutive patients (814 male; mean age, 55.5 ± 20.2 years) admitted to 10 hospitals (viz., Kyungpook National University daily clinical course, inpatient medications, treatments (including intensive care unit [ICU] admission, invasive MV, hemodialysis, and extracorporeal membrane oxygenation), and outcomes (including the length of stay, readmission, and mortality). All variables were available for all admitted patients except for presenting symptoms and laboratory findings (available in 9 of the 10 hospitals). Baseline comorbidities were available for all patients in the 10 hospitals. Among the comorbidities, CVRF was defined as a history of hypertension, diabetes mellitus, dyslipidemia, and current smoking. Known CVD was defined as a history of coronary artery disease, congestive heart failure, cerebrovascular accidents, and other chronic cardiac diseases. Moreover, chronic cardiac disease was defined as other cardiac conditions excluding coronary artery disease and congestive heart failure.

The data were expressed as mean ± standard deviation for continuous variables and as percentages for categorical variables. Comparisons between the baseline variables were performed using Student's t-test for continuous variables and Pearson's χ 2 test for categorical variables. The patients were categorized into two groups: group with preexisting CVRFs or CVDs and group without preexisting CVRFs or CVDs. Demographics, vital signs at admission, clinical presentation at admission, comorbidities, laboratory findings, treatment, and outcomes were compared between the two groups. Moreover, the prevalence rates of preexisting CVRFs or CVDs in hospitalized patients, treatments, and outcomes were compared by 10-year age intervals. We compared the prevalence rates of diabetes mellitus and hypertension between patients with COVID-19 and general population. The data regarding prevalence rates of diabetes mellitus and hypertension in general population were collected from Korea National Health And Nutrition Examination Survey (KNHANES) 2018. In addition, data regarding prevalence rates of diabetes mellitus and hypertension in general population of Daegu Metropolitan City were collected from Community Health Survey (CHS) 2019. The data are available in Korean Statistical Information Service (https://kosis.kr) and Community Health Survey (https://chs.cdc.go.kr), respectively. To determine the predictors of in-hospital death, multivariate logistic regression models were used to provide adjusted odds ratios (ORs) with 95% confidence intervals (CIs). Variables with P < 0.05 in univariate analyses were included in the multivariate model analysis. For all analyses, a two-sided P < 0.05 was considered statistically significant. Statistical analysis was performed using the Statistical Package for the Social Sciences, version 20.0 (IBM Corp., Armonk, NY, USA).

The Joint Institutional Review Board in Daegu City approved this study (No. 2020-07-003) as minimal-risk research using data collected for routine clinical practice and waived the requirement for informed consent. Table 1 presents the patients' baseline characteristics. Overall, the mean age was 55.5 ± 20.2 years, and 814 patients were male. Of all the patients, 954 (42.0%) had preexisting CVRFs or CVDs upon admission. Patients with preexisting CVRFs or CVDs were older and more likely to be male. Compared with those without preexisting CVRFs or CVDs, body mass index, systolic blood pressure, and respiratory rate were significantly higher in patients with preexisting CVRFs or CVDs, whereas O 2 saturation at admission was significantly lower. Respiratory symptoms such as cough, sputum production, sore throat, and rhinorrhea; discomfort; dysosmia; headache; and diarrhea were less frequent in patients with preexisting CVRFs or CVDs than those without, whereas dyspnea and altered consciousness were more frequent. Among the comorbidities, the most common were hypertension (28.8%) and diabetes mellitus (17.0%). Supplementary Fig. 1 presents the prevalence rates of hypertension and diabetes mellitus among the patients. The prevalence rates of diabetes mellitus and hypertension in patients with COVID-19 were comparable with those in the general population of in the KNHANES 2018. The prevalence rate of diabetes mellitus was numerically higher in COVID-19 patients compared with those in the general population of Daegu Metropolitan City in the CHS 2019. Chronic kidney disease, malignancy, chronic neurologic disorder, dementia, and psychiatric disorders were more frequent in patients with preexisting CVRF or CVD than in those without. known CVDs than those without, whereas hemoglobin and lymphocyte counts at baseline were significantly lower. Moreover, these results were consistent with the laboratory findings during the follow-up. Table 3 shows the univariate analysis for in-hospital death. In total, 164 (7.2%) patients died in the hospital. In the demographic findings, deceased patients were older and more likely to be male and obese. Regarding the vital signs at admission, the deceased patients had higher respiratory rates, lower O 2 saturation, and lower diastolic blood pressures at baseline. Patients with fever upon admission (P < 0.001) and systemic symptoms such as body malaise (P < 0.001) and myalgia (P = 0.001) had higher in-hospital mortality. Among the respiratory symptoms, hemoptysis (P = 0.001) and dyspnea (P < 0.001) were lower in the survivors than in the deceased patients, whereas cough, sore throat, and rhinorrhea were higher. Altered consciousness was higher (P < 0.001) and headache was lower (P < 0.001) in the deceased patients than in the survivors. Among the comorbidities, patients with preexisting CVRFs or CVDs such as diabetes mellitus (P < 0.001), hypertension (P < 0.001), coronary artery disease (P = 0.002), congestive heart failure (P < 0.001), and chronic cardiac disease (P < 0.001) had a higher in-hospital mortality. Among the other comorbidities, patients with bronchial asthma (P = 0.018), chronic obstructive lung disease (P = 0.025), chronic kidney disease (P < 0.001), malignancy (P < 0.001), chronic neurologic disease (P < 0.001), dementia (P < 0.001), and psychiatric disorders (P = 0.038) had higher in-hospital mortality. Among the laboratory findings, the inflammatory markers such as WBC count, CRP, hs-CRP, and pro-calcitonin; hepatic function markers such as aspartate aminotransferase, total bilirubin, and lactate dehydrogenase; renal function markers such as blood urea nitrogen and creatinine; and creatine kinase myocardial band (CK-MB) were higher in patients with in-hospital death at baseline and during follow-up, whereas lymphocyte and platelet counts and hemoglobin were lower ( Table 4) . WBC count, CRP, hs-CRP, and pro-calcitonin were statistically significantly higher in patients requiring intensive care and invasive MV at baseline and during followup (Supplementary Fig. 2) . Pulmonary infiltration on chest X-ray was presented in 44.3% (n = 989) and 55.6% (n = 1,240) of the patients at the time of admission and during hospitalization, respectively. The use of invasive MV was significantly greater in patients with pulmonary infiltration at the time of admission (0.9% vs. 5.2%, P < 0.001) and during hospitalization (0.5% vs. 4.6%, P < 0.001).

The prevalence rates of preexisting CVRFs or CVDs increased with age (P < 0.001) ( Table 5) . Moreover, the number of patients requiring intensive care (P < 0.001) and invasive MV (P < 0.001) increased with age. In-hospital death was significantly higher in the elderly (P < 0.001). During hospitalization, the need for intensive care (5.3% vs. 1.6%; P < 0.001) and invasive MV (4.3% vs. 1.7%; P < 0.001) was significantly greater in patients with preexisting CVRFs or CVDs than those without. Moreover, in-hospital mortality (12.9% vs. 3.1%; P < 0.001) was significantly higher in patients with preexisting CVRFs or CVDs. Among the CVRFs, diabetes mellitus (P < 0.001) and hypertension (P < 0.001) were associated with increased requirement of intensive care and invasive MV and in-hospital death (Fig. 1) . Among the CVDs, coronary artery disease (22.2% vs. 2.7%; P < 0.001) was associated with invasive MV. Coronary artery disease (33.3% vs. 7.1%; P = 0.002) and congestive heart failure (31.8% vs. 6.3%; P < 0.001) were associated with in-hospital death. Based on the multivariate analysis, preexisting CVRFs or CVDs (OR, 1.79; 95% CI, 1.07-3.01; P = 0.027) were independent predictors of in-hospital death after adjusting for confounding variables. were independent predictors of in-hospital death ( Table 6) . Moreover, advanced age, male gender, respiratory rate > 20/min, fever ≥ 37.5°C, altered consciousness, hemoptysis, and chronic neurologic disorders were independent predictors of in-hospital death.

The principal findings of this large observational study are as follows. First, it is uncertain whether diabetes mellitus and hypertension increase the risk of COVID-19 infection. Second, patients with COVID-19 with preexisting CVRFs or CVDs were more likely to have severe disease progression. Third, preexisting CVRFs or CVDs increased the mortality of patients with COVID-19.

Furthermore, three important clinical questions regarding the association between preexisting CVRFs or CVDs and COVID-19 infection should be considered. Our study provided important findings to address these important questions through a comprehensive analysis. 012 Data are presented as mean ± standard deviation. AST = aspartate aminotransferase, ALT = alanine aminotransferase, BUN = blood urea nitrogen, Cr = creatinine, aPTT = activated partial thromboplastin time, PT = prothrombin time, CRP = C-reactive protein, hs-CRP = high-sensitivity CRP, LDH = lactate dehydrogenase, CK-MB = creatine kinase-MB.

The first clinical question is whether diabetes mellitus and hypertension increase the risk of COVID-19 infection. SARS-CoV-2 binds to the angiotensin-converting enzyme 2 (ACE2) receptors in the lungs which are also associated with heart function, high blood pressure, and diabetes mellitus. 13 In animal studies, the expression of ACE2 is markedly increased in patients with diabetes mellitus, hypertension, and failing heart as an adaptive response to counteract the elevated level of angiotensin II. 14 Therefore, theoretically, diabetes mellitus and hypertension could increase the risk of COVID-19 infection. In studies from China that enrolled a small sample of patients with COVID-19 (200 or less), the prevalence rates of hypertension, diabetes, and CVD were comparable to those of the general population in 2018. 2 -6 However, the prevalence rate of CVRFs in patients with COVID-19 was less than that in the general population based on the findings of studies with a large sample of patients with COVID-19 (more than 1,000). 7 -9 However, these results are inconsistent with those in western countries. Based on the data from New York City, patients with COVID-19 had higher prevalence rates of hypertension (56.6% vs. 45%) and diabetes (33.8% vs. 10.5%) than the general population. 15 In the present study, the prevalence rates of hypertension and diabetes mellitus in patients with COVID-19 were comparable to those in the general population in the KNHANES 2018. However, the prevalence rate of diabetes mellitus in patients with COVID-19 showed numerically higher trend compared with those in the general population of Daegu Metropolitan City in the CHS 2019. Therefore, it is still uncertain whether diabetes mellitus and hypertension increase the risk of COVID-19 infection.

The second clinical question is whether patients with COVID-19 with preexisting CVRFs or CVDs are more likely to have severe disease. SARS-CoV-2 infection is a mild disease in most patients, but in some patients, it progresses to a serious respiratory disease causing hyperinflammation, multi-organ failure, and death. 16 Although a study from China reported that in patients with COVID-19, the requirement of invasive MV was greater in those with preexisting CVRFs or CVDs, this result was inconsistent with another study from China. 2,3 However, in the latest study, patients with COVID-19 with preexisting CVRFs or CVDs were more likely to progress to severe disease. 7 In our study, in patients with COVID-19, the requirement for intensive care and invasive MV was significantly greater in those with preexisting CVRFs or CVDs. In particular, preexisting coronary artery disease was associated with the use of and multi-organ failure might be directly or indirectly related with coronary artery disease. 17 COVID-19 is an infectious disease. Therefore, severe inflammatory response is associated with disease progression and poor prognosis. In this study, surrogate markers of severe inflammatory reaction such as WBC count, CRP, hs-CRP, and pro-calcitonin were greater in patients with preexisting CVRFs or CVDs at baseline and during the follow-up. Moreover, these surrogate markers were statistically significantly higher in patients requiring intensive care and invasive MV and in deceased patients. Although multiple possible explanations regarding the clear association between preexisting CVRFs or CVDs and COVID-19 severity exist, the greater inflammatory response in patients with preexisting CVRF or CVD is an important reason why patients with preexisting CVRFs or CVDs are more likely to have severe COVID-19.

The third clinical question is whether preexisting CVRFs or CVDs increase the mortality of patients with COVID-19. Studies from China reported that CVRFs or known CVDs are associated with increased in-hospital mortality. 4 -6 However, a study from a Western country reported that diabetes mellitus was associated with in-hospital death in patients with COVID-19 requiring intensive care and invasive MV, but hypertension was not. 15 It can be assumed that patients with preexisting CVRFs or CVDs are more likely to be older than those without. Advanced age has consistently been shown to be associated with poor prognosis in patients with COVID-19. However, most of the aforementioned studies did not adjust for age. Moreover, some studies showed that female were more resistant to viral infections than male, which is consistent with the results of this study. In animal models, male mice showed a higher susceptibility to SARS-CoV-1 infection. 18 diabetes mellitus, among the CVRFs, and congestive heart failure, among the CVDs, were independent predictors of in-hospital morality after adjusting for all variables.

However, this study has several limitations to consider. First, since the Daegu COVID-19 Research Project was an observational study, we cannot exclude the possibility of having residual confounding factors. Therefore, our results should only be regarded as hypothesis generating. Second, the study population only included patients with COVID-19 hospitalized in a Korean healthcare system in Daegu Metropolitan City. Third, history taking, and laboratory findings were not available in some patients. Moreover, some of the patients had missing laboratory data. Fourth, since this analysis was performed based on chart review without external prospective ascertainment, the results need to be interpreted with caution. Fifth, although the use of invasive MV might be related with the severity of pneumonia, the status of pneumonia was not obtained in our registry. Sixth, the frequency of ICU utilization in patients with coronary artery disease or cerebrovascular accidents was too small to explain the differences between patients with coronary artery disease or cerebrovascular accidents and those without. Further studies are required to clarify these associations. However, the limitations should not undermine the strength of this study including the overall consecutive patients with COVID-19 encountered in day-to-day clinical practice during the COVID-19 pandemic.

In conclusion, it remains uncertain whether patients with diabetes mellitus and hypertension are more causally vulnerable to COVID-19 infection. However, the patients with preexisting CVRFs or CVDs had worse clinical COVID-19 outcomes, mainly driven by a severe inflammatory reaction. Therefore, we should emphasize that appropriate risk stratification at triage for patients with preexisting CVRFs or CVDs is necessary for the patients' survival especially during this COVID-19 pandemic. Comparison of laboratory findings between patients admitted to intensive care units and those not admitted and between patients on invasive mechanical ventilation and those who are not at baseline and during the follow-up. Comparison of white blood cell count, C-reactive protein, high-sensitivity C-reactive protein, and pro-calcitonin between patients admitted to intensive care units and those not admitted (A). Comparison of white blood cell count, C-reactive protein, high-sensitivity C-reactive protein, and pro-calcitonin between patients on invasive mechanical ventilation and those who are not at baseline and during the follow-up (B).

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