key: cord-0724662-5uapxuku
authors: Pawar, Gayatri R.; Ratageri, Vinod H.; R, Udaykumar
title: Meningoencephalitis Associated with SARS-CoV-2 Infection
date: 2021-02-24
journal: Indian J Pediatr
DOI: 10.1007/s12098-021-03705-9
sha: c8d27355a0a5f7b837608f1df6d638979edc38b8
doc_id: 724662
cord_uid: 5uapxuku

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The child was treated with intravenous immunoglobulins (IVIG), mannitol, and other supportive therapy. Rapid recovery was noted with improvement in mentation, meningeal signs, and speech over 48 to 72 h. Steroid was not considered as the child improved with IVIG.

In view of raised inflammatory markers and positive serology and well response to immunoglobulin, PIMS variant was likely in our child. The probable mechanism was immunemediated neuronal damage due to cytokine storm syndrome causing neuronal cell edema, though neuroinvasiveness of coronaviruses is documented in humans [4] . Although seems early, we suggest screening of children presenting with encephalitis for COVID-19.

Distinct clinical and immunological features of SARS-CoV-2-induced multisystem inflammatory syndrome in children

Encephalitis associated with COVID-19 infection in an 11-year-old child

Meningoencephalitis from SARS-CoV-2 infection. ID Cases

Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms

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Conflict of Interest None.