key: cord-0723646-ted8q9hd authors: Panda, Soumya Ranjan title: Alliance of COVID 19 with pandemic of sedentary lifestyle & Physical Inactivity: Impact on Reproductive health date: 2020-07-15 journal: Taiwan J Obstet Gynecol DOI: 10.1016/j.tjog.2020.07.034 sha: 07009db708c82b8063fc29b5b3ad4f9566b587e5 doc_id: 723646 cord_uid: ted8q9hd nan This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Sustained physical inactivity and sedentary behaviour are found to be associated with poor physical and mental health and increased disease-specific morbidity and mortality risk. Even a short period of exposure to such type of life style can be dangerous. It has been seen that reduction in daily steps from ~10,000 to ~1,500 steps for a mere 2-week period is associated with consequences like impaired insulin sensitivity and lipid metabolism, increased visceral fat and decreased fat-free mass and cardiovascular fitness in healthy adults. It is interesting to note that, even episodes of exercises of moderate-intensity cannot counteract the ill effects of 4 days of inactivity. [2] In men, moderate physical activity has been positively associated with semen quality. Moderate physical activity has been found to be associated with increased fecundity parameters and live birth rates, regardless of body mass index (BMI)-even during assisted reproductive treatment. [3, 4] It has been seen that 1.5 hour or more of aerobic physical activity per week resulted in a higher likelihood of live birth in women undergoing IVF compared to inactive women. [5] Palomba et. el performed a retrospective cohort study involving obese infertile women undergoing IVF/ICSI (216 cycles). They found a significantly higher pregnancy rates and live birth rate in the group that was engaged in regular physical activity (41 cycles), with a 3.71 relative risk of live birth. [3] Sedentary behaviour has been associated with the increased secretion of leptin, which can decrease fertility and pregnancy rates through the down regulation of the hypothalamic-pituitary-ovarian (HPO) axis. Interrupting the amount of time spent sitting was related to decrease visceral adiposity and BMI. Attacking the pandemic of physical inactivity: what is holding us back? Inactivity induces resistance to the metabolic benefits following acute exercise Physical activity before IVF and ICSI cycles in infertile obese women: an observational cohort study A prospective cohort study of physical activity and time to pregnancy EARTH Study Team. Maternal physical and sedentary activities in relation to reproductive outcomes following IVF Measures taken to combat COVID19 pandemic may promote sedentary life style and there by exacerbating another established global pandemic known as physical inactivity. With a little awareness of the above fact we can prevent a significant impact of this pandemic on reproductive health. Clinicians can help out their patients in promoting and proposing a lifestyle supportive care.Even if we need to restrict ourselves indoor, care must be taken to spend more time in indoor physical activity and less time in sitting.