key: cord-0722896-vx1xnj0t
authors: Hussain, Moosa; Ali, Mohamed; Ismail, Mohamed; Soliman, Mohame; Muhsin, Milza; Nazeer, Aminath; Solih, Maeesha; Arifa, Aminath; Latheef, Ali; Ziyan, Ahmed; Shaheed, Ahmed; Luthufee, Nazla; Rafeeq, Nazla; Shifaly, Aishath; Moosa, Sheena
title: Management of the first severe case of COVID19 in the small islands of Maldives
date: 2020-06-07
journal: Respir Med Case Rep
DOI: 10.1016/j.rmcr.2020.101118
sha: bd41be6c0710c0c4c2303897581005d3708e25d6
doc_id: 722896
cord_uid: vx1xnj0t

The first cases of COVID19 in the Maldives was reported on 7th March 2020 with a total of 13 cases by 27th March from number of resort islands and were confined to the islands in which the cases were detected. This report describes the clinical course and management of the first severe case that required intensive care. Treatment strategy adopted was supportive and patient improved wit timely symptomatic management. This case highlights the importance of epidemiological surveillance and active case finding to detect and diagnose the case at an early stage for appropriate clinical management for positive outcomes in high risk groups.

The novelty of COVID-19 has prompted documentation of clinical observations and experience in the management of COVID-19 cases in different settings. This case describes the clinical course and management of the first hospitalised case of COVID -19 in Maldives, a small island setting with limited medical resources.

The patient, a 69-year-old male, had travelled to Maldives from Italy -this was a high risk country as designated by the Health Protection Agency (HPA), the department leading the COVID -19 response in Maldives. The patient, who presented to the resort doctor within three days of arrival with a history of symptoms suggestive of COVID -19, was identified through the surveillance mechanism instituted as a core feature of the pandemic preparedness and response to COVID -19 in Maldives. He was assessed and taken to an isolation facility as a suspected case of COVID -19. He was tested for SARS-nCOV2 with RT-PCR assay returning a positive result, while tests were negative for Influenza A and B. At the time of detection, the patient had a fever for two days with no history of cough or shortness of breath, had no known comorbidities and was not on any medication. Physical examination recorded a temperature of 100.8 , and other vital signs normal. The case was then reported to the HPA.

The patient's condition rapidly deteriorated with dyspnea, on day five of symptom onset, and was transported to the island of Male' to the designated intensive care unit (ICU) for COVID -19, with the working diagnosis of COVID -19 with bilateral pneumonia. Lung auscultation showed crepitation in the interscapular and infrascapular regions on both lungs. A chest x-ray showed bilateral, peripheral ground glass opacities more evident in both bases, consistent with the changes in respiratory status (Figure 1 ). At this time, the treatment strategy was supportive and management was consistent with the interim guidance of World Health Organization on clinical management of severe acute respiratory infection (SARI) when COVID-19 disease is suspected. 1 Over the first six days of ICU admission, despite increasing oxygenation, maintaining oxygen saturation was difficult and varied between 89 to 94% with oxygenation at 3lit/min. The patient continued to have persistent fever and developed diarrhoea during this period. The patient was at high risk of severe disease, being an elderly person of 69 years, but had no comorbidities. The clinical findings are consistent with those reported in literature, with relatively late onset of dyspnea, on day five of symptom onset, anaemia, dyselectrolytema and cardiac injury. 4, 5 The treatment protocol evolved during the course of the case management. A supportive treatment regimen with a combination of antivirals 6 and antibiotics resulted in rapid improvement clinically and a positive patient outcome. Oxygenation was managed with high flow nasal cannula with the target SpO2 of 94% 7 and was central to the clinical management. The observation of arrhythmias is likely associated with hypocalcemia 8 . During the illness, the patient also developed anemia, which has been reported in some of the more severe COVID-19 cases. 9 In this case, the anemia improved with clinical improvement, without any specific intervention. However, given the high prevalence of thalassemia carriers among the population (16% to 18%), 10 management of anemia will need careful consideration among local patients.

Epidemiological investigation showed travel history from a country with COVID -19 community spread and it is likely that the patient was exposed to infection from their last travel destination. The case was, classified as an imported case of COVID -19 to Maldives. In conclusion, the clinical and biochemical findings of the imported severe case of COVID -19 in Maldives is consistent with other reported findings in the literature. Prompt oxygenation and supportive management proved effective in producing positive clinical outcomes. The surveillance and active case finding measures instituted in the country allowed for early diagnosis that allowed timely treatment and recovery of the case.

Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors

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