key: cord-0720598-acj6n9ba authors: Srinivasan, K. N.; Sathyamurthy, I.; Neelagandan, Manodaya title: Relation between COVID-19 vaccination and myocardial infarction – Casual or coincidental? date: 2021-06-07 journal: IHJ Cardiovascular Case Reports (CVCR) DOI: 10.1016/j.ihjccr.2021.05.003 sha: 0ad12c10003318c9f1884bf104bc407ba3efbadb doc_id: 720598 cord_uid: acj6n9ba nan Increase in rate of cardiovascular disease (CVD) has been evidenced in patients infected with novel coronavirus of 2019 . Corona viruses are "single stranded RNA viruses" that primarily affect the respiratory system in humans and animals. The World Health organization (WHO) declared COVID-19 as an outbreak pandemic after development of pneumonia due to the severe acute respiratory syndrome corona virus-2 1 (SARS-CoV-2). Research has shown high mortality rates due to co-existence of viral pneumonia and cardiac co-morbidities. Many infected individuals presented in the form of myocarditis, acute coronary syndrome (ACS) 2 , stress cardiomyopathy, arrhythmias, Type II myocardial infarction (MI) and silent left ventricular (LV) dysfunction. The disarray of coagulation and fibrinolytic system was found to be the main reason for the increased incidence of arterial and venous thrombi in these patients 3 Further research data can aid to determine direct causal host-vaccine relationship. Until then, an absolute contraindication towards COVID-19 vaccination cannot be implemented to the population. As the benefits overweigh the side effects, it is well understood that immunization is mandatory for the population. Any untoward incidence after vaccination must be dealt as with any other conventional cardiac ailment. No specific post-vaccination cardiac management regimes are recommended till date. For now, therapeutic protocols unique to the individual case is suggested. No funding involved from any source. J o u r n a l P r e -p r o o f Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Pathogen recognition and inflammatory signaling in innate immune defenses COVID-19 for the Cardiologist: Basic Virology, Epidemiology, Cardiac Manifestations, and Potential Therapeutic Strategies COVID-19 in critical care: epidemiology of the first epidemic wave across England, Wales and Northern Ireland Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomized controlled trials in Brazil, South Africa, and the UK Untimely Myocardial Infarction or COVID-19 Vaccine Side Effect Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial