key: cord-0718698-66tg39ji
authors: Bakhle, Anish; Sreekumar, Kavita; Baracho, Bonny; Sardessai, Sanjay; Silveira, Maria Piedade
title: Cavitary lung lesions in a neonate: Potential manifestation of COVID‐19 related multisystem inflammatory syndrome
date: 2021-10-29
journal: Pediatr Pulmonol
DOI: 10.1002/ppul.25732
sha: e71f15ada5cf77ed3ad9d1ff3f16f19d7c795916
doc_id: 718698
cord_uid: 66tg39ji

BACKGROUND: The hyperinflammatory state of multisystem inflammatory syndrome in children (MIS‐C) predisposes to thromboembolic complications. We report a neonate with multiple cavitary lesions in lung, which we suspect could be a manifestation of multisystem inflammatory syndrome in neonate (MIS‐N) following maternal COVID‐19 infection during pregnancy. CASE REPORT: Eight‐day‐old neonate was referred with fever and fast breathing. Mother was positive for COVID‐19 in 29th week. COVID‐19 reverse‐transcription polymerase chain reaction was negative, however, antibodies were positive. He had increased leucocyte count, and elevated levels of C‐reactive protein (CRP), procalcitonin, ferritin, lactate dehydrogenase, and d‐dimer along with bilateral reticulonodular opacities on chest radiograph and multiple nodules with evidence of cavitation in both lungs on chest tomography. All cultures were negative. A possible diagnosis of MIS was made. Infant was treated with intravenous immunoglobulin (IVIG) which he responded to with resolution of symptoms. CONCLUSION: Neonates exposed to COVID‐19 should be evaluated for thromboembolic complications and IVIG can be one of the treatment modalities.

). The neonate was initiated on broad-spectrum antibiotics and oxygen via nasal canula. 

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Cavitary lung lesions in a neonate: potential manifestation of COVID-19 related multisystem inflammatory syndrome