key: cord-0718518-x22ngsv4 authors: Mohapatra, Ranjan K.; Kandi, Venkataramana; Tuli, Hardeep S.; Chakraborty, Chiranjib; Dhama, Kuldeep title: The recombinant variants of SARS‐CoV‐2: Concerns continues amid COVID‐19 pandemic date: 2022-04-27 journal: J Med Virol DOI: 10.1002/jmv.27780 sha: 546ef14f76017035d3b3c0e4e190f0634de4b226 doc_id: 718518 cord_uid: x22ngsv4 nan In the beginning of 2022, we have highlighted the proposed concept of simultaneous attack of Delta (most deadly) and Omicron (most mutated) in the immunocompromised people, which is an extremely rare event. 1 strain has the Spike and structural proteins from BA.2 but the 5′ part of its genome is from BA.1. WHO has warned that the new mutant "XE" variant of Omicron may be more transmissible than any strain of SARS-CoV-2/COVID-19 seen before. A community growth rate advantage of~10% has been indicated in early data estimation for XE as compared to BA.2, however, such finding need further explorative investigations for knowing the real magnitude of infection. XE has been reported to belong to Omicron variant until significant differences in transmissibility and disease outcome may be seen. 5 To the surprise of the scientific world, a recent report had increasing in the next two consecutive weeks, followed by new cases declined again but still, there are nearly 1.5 million new cases being added daily to the total tally of COVID-19 cases. 5, 13 As of April 3, 2022, more than 491 million confirmed cases and over 6.1 million deaths have been reported amid the ongoing COVID-19 pandemic. 14 A concern has been raised by the WHO with regard to the recent significant decrease in SARS-CoV-2 testing by many countries, and in such scenario, the collected data to be analyzed are progressively less Twin combination of Omicron and Delta variants triggering a tsunami wave of ever high surges in COVID-19 cases: a challenging global threat with a special focus on the Indian subcontinent Evidence for SARS-CoV-2 delta and omicron-infections and recombination Deltacron: the story of the variant that wasn't The "wolf" is indeed coming: recombinant "deltacron" SARS-CoV-2 detected. China CDC Weekly World Health Organization. COVID-19 Weekly Epidemiological Update Covid-19: what do we know about the delta omicron recombinant variant? Omicron: a chimera of two early SARS-CoV-2 lineages Accurate single nucleotide variant detection in viral populations by combining probabilistic clustering with a statistical test of strand bias Genetic linkage analysis in the age of wholegenome sequencing Detecting SARS-CoV-2 variants with SNP genotyping The threat of the spread of SARS-CoV-2 variants in animals World Health Organization. WHO Coronavirus (COVID-19) Dashboard The mysterious origins of the Omicron variant of SARS-CoV-2. Innovation 529) variant, salient features, high global health concerns and strategies to counter it amid ongoing COVID-19 pandemic Hur har omikron uppstått och varför sprider den sig så snabbt? [How did Omicron evolve and why does this SARS-CoV-2 variant spread so fast? Origin and evolutionary analysis of the SARS-CoV-2 Omicron variant Evidence for a mouse origin of the SARS-CoV-2 Omicron variant SARS-CoV-2 Omicron emergence urges for reinforced One-Health surveillance Omicron (B.1.1.529) variant of SARS-CoV-2: concerns, challenges, and recent updates All authors are thankful to their respective institutes and universities. The authors declare no conflicts of interest. Data Availability Statement is not available.