key: cord-0717952-xmjj1s5s
authors: Dash, S.; Sirka, C.S.; Mishra, S.; Viswan, P.
title: Covid‐19 vaccine induced Steven‐Johnson syndrome: a case report
date: 2021-06-03
journal: Clin Exp Dermatol
DOI: 10.1111/ced.14784
sha: 2cd007ed8b6b5066bceac84990d1aecfbf0b3f77
doc_id: 717952
cord_uid: xmjj1s5s

Steven‐Johnson syndrome (SJS) is a severe cutaneous adverse drug reaction. Its occurrence due to vaccines is scant.(1) We report a case of SJS caused by COVID‐19 vaccine in an adult. A 60‐year‐old male presented with complaints of fever, oral ulceration and skin rash three days after the first dose of COVID‐19 vaccine, for which he visited a local physician and was prescribed paracetamol and levocetrizine, inspite of which the symptoms were not controlled and gradually the rashes became generalised in distribution.

This article is protected by copyright. All rights reserved A 60-year-old male presented with complaints of fever, oral ulceration and skin rash three days after the first dose of COVID-19 vaccine, for which he visited a local physician and was prescribed paracetamol and levocetrizine, inspite of which the symptoms were not controlled and gradually the rashes became generalised in distribution. The patient presented to the emergency department after seven days of development of lesions, throughout which the fever was persisting.

On cutaneous examination, there were multiple purpuric macules present all over the body with peri-lesional erythema. The lesions coalesced to form large sheets of necrosed skin over front and back of trunk, with few areas showing bullae. Mucosal involvement was present in the form of oral erosions, hemorrhagic crusting over the lips, eye congestion and erosions over the glans ( Fig.1) . Based on the course and morphology, SJS was suspected and a detailed drug history was elicited, which revealed the patient was on teneligliptin, metformin and amlodipine for diabetes and hypertension respectively since last six months. Rest of the drugs were prescribed after the patient developed fever and skin rash and the patient denied any other drug intake before 

Vaccine-induced toxic epidermal necrolysis: A case and systematic review

A study of agreement between the Naranjo algorithm and WHO-UMC criteria for causality assessment of adverse drug reactions. Indian journal of pharmacology

Immune-mediated adverse reactions to vaccines

Vaccine-induced toxic epidermal necrolysis: A case and systematic review

Accepted Article This article is protected by copyright. All rights reserved

Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial