key: cord-0711976-04eicck8 authors: Ng, Chris Fook Sheng; Seposo, Xerxes T.; Moi, Meng Ling; Tajudin, Muhammad Abdul Basit Ahmad; Madaniyazi, Lina; Sahani, Mazrura title: Characteristics of COVID-19 epidemic and control measures to curb transmission in Malaysia date: 2020-10-17 journal: Int J Infect Dis DOI: 10.1016/j.ijid.2020.10.027 sha: e290fb42107ba83ac42c748bd2d95ed2c1d6b5ff doc_id: 711976 cord_uid: 04eicck8 The first wave of COVID-19 epidemic began in late January in Malaysia and ended with a very small final size. The second wave of infections broke out in late February and grew rapidly in the first 3 weeks. Authorities in the country responded quickly with a series of control strategies collectively known as the Movement Control Order (MCO) with different levels of intensity matching the progression of the epidemic. We examined the characteristics of the second wave and discussed the key control strategies implemented in the country. In the second wave, the epidemic doubled in size every 3.8 days (95% confidence interval [CI]: 3.3, 4.5) in the first month and decayed slowly after that with a halving time of approximately 3 weeks. The time-varying reproduction number R(t) peaked at 3.1 (95% credible interval: 2.7, 3.5) in the 3rd week, declined sharply thereafter and stayed below 1 in the last 3 weeks of April, indicating low transmissibility approximately 3 weeks after the MCO. Experience of the country suggests that adaptive triggering of distancing policies combined with a population-wide movement control measure can be effective in suppressing transmission and preventing a rebound. The first case of coronavirus disease 2019 was confirmed in Malaysia on January 25, 2020, marking the first wave of infection in the country that lasted for about 3 weeks (MOH, 2020) . The total number of cases was low, with 22 confirmed infections, 20 of which were imported, and no fatality. Here, we describe the characteristics of the second wave of COVID-19 epidemic in the country and recount the major control strategies. Refer to the supplementary material. By the end of August, there were 9340 confirmed cases with a recovery rate of 96.9%. Imported cases made up 8.8% (826), while a total of 127 deaths were reported. The nationwide 14-day delay-adjusted case fatality rate is 1.4% (95% confidence interval: 1.2%, 1.6%) for the current study period. The second wave of the epidemic began on February 27 and grew at a rate of 18% (95% confidence interval: 15%, 21%) per day, with a doubling time of 3.8 the predicted number of daily cases for the second wave based on two exponential models, one for the growth phase starting from February 27 to March 26 (asterisk), and another for the decay phase starting from March 27 to May 3, a day before the CMCO. Dotted lines represent the corresponding 95% confidence interval. Recovery Movement Control Order (RMCO). Our results suggest that the COVID-19 epidemic in Malaysia appears to be under control. Analyses show that approximately 3 weeks after the MCO, disease transmissibility has reduced substantially and remained low for the remaining time period, except for two upswings that occurred in late May and early June due to transmissions among foreigners in detention centers ( Figure 2 ) (MOH, 2020). Decline in transmissibility started a few days before the official MCO measure, likely because of more public awareness and reduced social mixing because of earlier reports of increases in confirmed cases. A mixture of interventions was implemented to curb spread. In the early stages of the second wave, authorities responded with MCO, a strict nationwide order to limit movement and border travel, in addition to ongoing contact tracing and proactive surveillance among individuals with influenza-like illness and severe acute respiratory infection. Communitytargeted mass testing was also implemented selectively to contain epidemic hotspots. Exit strategy was executed in a few stages. The national MCO was replaced by CMCO and J o u r n a l P r e -p r o o f eventually by RMCO, while numerous new social distancing measures were introduced to suppress spread and prevent resurgence (Petersen et al., 2020) . For example, restriction on the number of worshipers to the size of the buildings, staggered reopening of schools prioritizing students who will be taking school leaving examinations, a limitation of 250 people in public events, and access to digital technology to aid contact tracing, interstate travel, and selfevaluation which is useful for those under surveillance or quarantines. These strategies are consistent with the suggestions of some early reports that noted combining multiple measures might offer effective options to minimize the risk of further lockdowns (Chen et al., 2020; Colbourn, 2020; Cowling et al., 2020; Giordano et al., 2020; Prem et al., 2020) . Our observations suggest that intermittent triggering of adaptive measures coupled with population-wide distancing policies and proactive surveillance have provided effective control against the epidemic in the country. Until viable pharmaceutical options become available, the continuous evaluation of non-pharmaceutical strategies and the support for those disproportionately affected will be important. CFSN and XS conceived the study with input from MS, MLM, LM and MABAT. CFSN extracted the data which was validated by MABAT. CFSN led the analysis with inputs from XS and MS. All authors contributed to the interpretation and writing of the final draft. None. None. 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