key: cord-0710533-xm222pth
authors: Rajendram, Rajkumar; Kharal, Ghulam Abbas; Mahmood, Naveed; Puri, Rishi; Kharal, Mubashar
title: Rethinking the respiratory paradigm of COVID-19: a ‘hole’ in the argument
date: 2020-06-02
journal: Intensive Care Med
DOI: 10.1007/s00134-020-06102-6
sha: cc65f691d7506313b318e2107babc52794b212bd
doc_id: 710533
cord_uid: xm222pth

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The number of admissions was more than the hospital had ever seen. Patients were dying of respiratory failure. Doctors and nurses were unable to cope. At Blegdam Hospital, Copenhagen in 1952, Bjørn Ibsen's use of invasive positive pressure ventilation, then revolutionary, saved countless lives from polio and initiated the development of intensive care units (ICUs) [1] .

In 2020, ICUs around the world are flooded with coronavirus disease 2019 (COVID-19). The response to this pandemic has focused on increasing availability of intensivists, ICU beds, and ventilators. So, in keeping with Maslow's law of the hammer, these patients are generally being treated as if they have acute respiratory distress syndrome (ARDS).

However, the ' ARDS' caused by COVID-19 is atypical [2, 3] . We therefore read the editorial written by Gattinoni et al. [2] with great interest. They describe two distinct patterns of respiratory COVID-19 (type L, low elastance and type H, high elastance) [2] . However, there is a 'hole' in their argument. A series of patients with COVID-19, also described by Gattinoni's group; had a mean shunt fraction of 0.50 ± 0.11 despite relatively preserved pulmonary compliance (50.2 ± 14.3 ml/cmH 2 O) [3] .

The cause of this shunt is likely to be multifactorial. Further consideration of its aetiology may be important. Right-to-left (RTL) shunt may be extrapulmonary (EPS) and/or intrapulmonary (IPS). A degree of IPS is inevitable. However, EPS may be present in some patients with COVID-19.

Extrapulmonary shunt is often intracardiac (ICS) [4] . Echocardiography with bubble contrast, a minimally invasive bedside test, can be used to detect ICS [4] . This is most commonly due to patent foramen ovale (PFO) [4] . Hypoxia is an uncommon complication of PFO unless a precipitant such as COVID-19 initiates RTLICS. However, because the prevalence of PFO in the general population is 20-30%, EPS may be relevant to many patients with COVID-19 worldwide.

We therefore suggest that respiratory failure should be classified into four dynamic phenotypes based on total shunt (i.e. IPS ± EPS) and lung mechanics:

Type L respiratory failure • due to IPS alone (Subtype LPS) • due to IPS and EPS (Subtype LES)

Type H respiratory failure • due to IPS alone (Subtype HPS) • due to IPS and EPS (Subtype HES)

Worsening pulmonary pathology progresses from Type L to H. Increasing airway pressures could induce HES [5] . There are few data to guide management of patients with EPS. However, the standard approach to refractory hypoxia may exacerbate RTLICS whilst trying to reduce IPS [5] . The patients with RTLICS respond poorly to positive end expiratory pressure are ventilated longer, and stay longer in ICU [5] . Reducing airway pressures may allow reversion to HPS. As the lung injury resolves, both total shunt and lung mechanics may normalise.

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