key: cord-0708997-b916qus4
authors: Sanders, David J; Bomman, Shivanand; Krishnamoorthi, Rajesh; Kozarek, Richard A
title: Endoscopic retrograde cholangiopancreatography: Current practice and future research
date: 2021-08-16
journal: World J Gastrointest Endosc
DOI: 10.4253/wjge.v13.i8.260
sha: 7004eae15cad565686d092120e3ebb1fb1f2f369
doc_id: 708997
cord_uid: b916qus4

Endoscopic retrograde cholangiopancreatography (ERCP) has evolved from a primarily diagnostic to therapeutic procedure in hepatobiliary and pancreatic disease. Most commonly, ERCPs are performed for choledocholithiasis with or without cholangitis, but improvements in technology and technique have allowed for management of pancreatic duct stones, benign and malignant strictures, and bile and pancreatic leaks. As an example of necessity driving innovation, the new disposable duodenoscopes have been introduced into practice. With the advantage of eliminating transmissible infections, they represent a paradigm shift in quality improvement within ERCP. With procedures becoming more complicated, the necessity for anesthesia involvement and safety of propofol use and general anesthesia has become better defined. The improvements in endoscopic ultrasound (EUS) have allowed for direct bile duct access and EUS facilitated bile duct access for ERCP. In patients with surgically altered anatomy, selective cannulation can be performed with overtube-assisted enteroscopy, laparoscopic surgery assistance, or the EUS-directed transgastric ERCP. Cholangioscopy and pancreatoscopy use has become ubiquitous with defined indications for large bile duct stones, indeterminate strictures, and hepatobiliary and pancreatic neoplasia. This review summarizes the recent advances in infection prevention, quality improvement, pancreaticobiliary access, and management of hepatobiliary and pancreatic diseases. Where appropriate, future research directions are included in each section.

This coronavirus disease 2019 (COVID-19) pandemic has changed our collective understanding of infection transmission, vaccine development, and the challenges of providing continuity of care in a rapidly evolving health care crisis. The evolution in endoscopic retrograde cholangiopancreatography (ERCP) has been more gradual, but certainly there have been periods of innovation punctuated by rapid change. Given the global pandemic, an area of interest with accelerated focus is the use of disposable duodenoscopes to break the chain of infection in ERCP. With rising concerns over reusable duodenoscopes implicated in nosocomial outbreaks, the trend toward transitioning to disposable components and completely disposable duodenoscopes has begun.

As highlighted in previous reviews, ERCP has moved from a diagnostic to primarily therapeutic procedure [1] . The therapeutic indications for ERCP include stones in the biliary and pancreatic ducts, benign and malignant strictures, and bile and pancreatic leaks [1] . Despite the near ubiquitous access to advanced radiology and endoscopic ultrasound (EUS) in North America, ERCP still has diagnostic indications in patients with a solitary dilated duct, cholangiocarcinoma, primary sclerosing cholangitis, and autoimmune cholangitis. This article will focus on the current state of practice for diagnosing and managing hepatobiliary and pancreatic disease with ERCP in 2021.

As competency-based training programs have evolved to include EUS and ERCP, hybrid procedures have evolved. Any future textbooks will have to include both procedures given their complementary nature. In addition to the advances made in these hybrid procedures, our focus should remain on clinical success and mitigating risk independent of technical success during a single procedure. This article will review the progress made since the last review in this journal [2] and clarify future research directions in the field.

While some practice changes in ERCP have been adopted because of an enthusiasm for technologic advance and the opportunity to treat complex problems, this past year was a somber reminder of our oath to do no harm. At no point in our history has there been a greater focus on infection prevention in health care with the ever-present threat of COVID-19. The prevention of transmissible infections has added cost and complexity to the reprocessing of duodenoscopes. Duodenoscopes have a complex design with intricate moving parts, long working channels, and are heat labile which make them difficult devices to disinfect [3] . Contaminated duodenoscopes have been implicated in the spread of multidrug resistant organisms [4] [5] [6] [7] . Several measures have been taken to improve the disinfection process to mitigate cross contamination [8] . Along with this, the Food and Drug Administration (FDA) recommended a transition to a newer design of duodenoscopes with disposable components which can simplify the disinfection process[9]. This has also led to innovations in duodenoscope design which include disposable parts and the development of a completely disposable duodenoscope.

Development of a single-use duodenoscope began in 2017. The challenge was manufacturing a scope comparable in performance and efficacy to a conventional reusable duodenoscope and eliminate the risk of any cross contamination[10]. Although there have been disposable bronchoscopes, nasopharyngoscopes, and ureteroscopes in clinical use, a disposable scope in gastroenterological clinical practice has been unprecedented[10]. In December 2019, the FDA cleared the first fully disposable duodenoscope -EXALT™ Model D Single-Use Duodenoscope (Figure 1 ), Boston Scientific Corporation (Marlborough, MA, United States) [11] . The endoscope has a 4.2 mm working channel, LED light, and conventional four-way steering. The current model D has a similar elevator lift angle and viewing angle when compared to the available reusable duodenoscopes. Subsequently in July 2020, a second disposable duodenoscope was cleared by the FDA-Duodenoscope model aScope™ Duodeno,

Advantages of a single-use duodenoscope are that they are sterile with no risk of cross contamination between patients. There is no need for disinfection or reprocessing, and it also eliminates the cost of maintenance and repair. Initial studies with the use of disposable duodenoscopes in a bench model, real patients, and a randomized study comparing with conventional duodenoscopes have shown equivalent performance characteristics compared to reusable duodenoscopes[10,12, 13]. The significant disadvantages of the adoption of disposable duodenoscopes are the increased costs and increased environmental waste [14] . Further studies on the safety, efficacy, costs, patient outcomes, and environmental impact will help navigate the transition toward these novel devices.

ERCP has become safer with better equipment, standardized training programs, and better periprocedural care. As ERCP applications have broadened to include other modalities like EUS, there has been a significant increase in the use of involvement of anesthesia services in endoscopy. The safety of anesthesia-directed sedation in endoscopy is complex to analyze, but now better understood.

Safe sedation is a dynamic process that allows for technical and clinical success. In a United Kingdom study of therapeutic procedures, sedation was deemed inappropriate in up to 14% of cases [15] . Prior to Propofol use and general anesthesia, intolerance of sedation with discomfort was noted in one third to one half of ERCPs [16] . Comorbid patients with higher American Society of Anesthesiologist scores are more likely to have anesthesiologist involvement [17] . The safety of anesthesia service in endoscopy was analysed in a large cross-sectional study using the National Anesthesia Clinical Outcomes Registry. A total of 27721 patients had an ERCP performed with 12 deaths and 1052 anesthesia-related complications reported [17] . In the unadjusted model, ERCP was associated with an elevated odds ratio (OR) of 8.83 [95% confidence interval (CI): 7.70-10.12] relative to colonoscopy, that was not significant in the multivariate analysis.

Propofol is a sedative and hypnotic medication with a shorter duration of action compared to midazolam and fentanyl. Benefits of propofol include improvements in patient satisfaction, procedural outcome, and quicker recovery when compared to procedural sedation [18] [19] [20] . Propofol can cause significant hypotension and rapid respiratory depression. Further study was required to clarify propofol's safety in endoscopy. The ProSed 2 study [21] was a large multicenter prospective study reviewing sedation methods and associated complications of which 20967 procedures (6.7%) were ERCPs. The lowest rates of sedation-related complications were in patients receiving propofol monotherapy, and only 5 reported fatalities occurred during these ERCPs. An important point from the study is that their data collection focused on adverse events related to sedation alone, and delayed complications were not included. As with the Lieber study[17], delayed adverse events like post ERCP pancreatitis would not be captured by the author's study design [22] . Respiratory complications are more common in upper endoscopies [17] , and the decision to intubate a patient remains individualized to the nature of the intended procedure and the patient's comorbidities. If anesthesia services are involved at our institution, any decision regarding the patient's anesthesia and intubation is collaborative with shared care decision making. the landmark trial published in the NEJM assessing the benefits indomethacin for post ERCP prophylaxis, more than 80% of patients also received a pancreatic duct stent [27] . The dose of rectal indomethacin used in the study was 100 mg. There was a reduction in post ERCP pancreatitis in both patients who received a stent (16.1% to 9.7% P = 0.04) and those who did not (20.6% to 6.3% P = 0.049). Post hoc analysis of this data suggested that the use of rectal indomethacin alone was better than a stent alone or the combination of stent and rectal indomethacin [29] . Despite data to support rectal indomethacin given before the procedure [30] , and the double wire technique [31], the current state of practice remains individual to the practitioner. Side effects of long-term nonsteroidal anti-inflammatory drug use include renal impairment and peptic ulcer disease. A single dose of indomethacin did not result in a significant risk of acute renal impairment or clinically significant gastrointestinal bleeding [27] . The stent vs indomethacin for preventing post-ERCP pancreatitis (SVI) trial will clarify the value of a prophylactic pancreatic stent when added to rectally administered indomethacin[29] and should help further define standards of practice.

Cannulation techniques have continued to evolve with advances in equipment [32] . Adding the EUS rendezvous may represent the last advance necessary to achieve 100% cannulation success during the index procedure. However, the additional risk of adding an EUS rendezvous to the index procedure needs to be evaluated prospectively in many centers. Failed cannulations are currently managed with a referral to interventional radiology for percutaneous transhepatic cholangiography (PTC). Biliary access and management would take the form of a combined PTC with ERCP, PTC with formation of an established tract, or antegrade stenting and stone removal [ 

Given the burden of obesity and weight loss surgeries, expertise in altered surgical anatomy ERCP is necessary at tertiary referral centers. In a previous systematic review of overtube-assisted enteroscopy (OAE) and ERCP[39], patients with a Roux-en-Y with gastric bypass had a technically successful ERCP in just 70% of cases. Additionally, patients with a Roux-en-Y and either a hepaticojejunostomy (Figure 2 ) or pancreaticoduodenectomy undergoing ERCP had success in 76% of cases. A systematic review and meta-analysis[40] published in 2020 included 10 studies reporting a total of 398 procedures. The pooled rates of technical success of enteroscopy and OAE-ERCP were comparable at 75.3% (95%CI: 64.5-83.6) and 64.8% (95%CI: 53.1-74.9), respectively. The pooled rate of adverse events was 8.0% (95%CI: 5.2-12.2). The pooled rate of enteroscopy success with a double-balloon enteroscope in the 4 available studies was 83.5% (95%CI 68.3-92.2). Importantly, technical success of double-balloon enteroscopy ERCP (DBE-ERCP) was also higher at 72.5% (95%CI: 52.3-86.4) . The pooled rate of adverse events with DBE-ERCP was 9.0% (95%CI: 5.4-14.5) [40] .

Another approach to altered anatomy is the laparoscopic surgery-assisted ERCP [41]. At our institution, this surgery involves 4 Laparoscopic ports placed under direct visualization, formation of a gastrotomy, and placement of a rigid 19 mm sigmoidoscope into the gastrotomy. The duodenoscope is advanced through the sigmoidoscope, pylorus, and into the duodenum [42] . A meta-analysis in 2020 found that laparoscopic assisted surgery is significantly more effective than enteroscopyassisted ERCP [43] . Therapeutic success was defined as completion of the diagnostic or therapeutic indication of the ERCP. The pooled proportion of patients with therapeutic success was higher in the surgery group at 97.9% (95%CI: 96.7-98.7) compared to 73.2% (95%CI: 62.5-82.6) in the enteroscopy-assisted ERCP patients. The benefits were countered by a higher rate of adverse events (19%; 95%CI: 12.6-26.4 vs 6.5%; 95%CI: 3.9-9.6) and a longer procedural time (158.5 min SD ± 20 vs 100.5 min SD ± 19.2 min).

Given the challenges in managing patients with altered anatomy, EUS-directed transgastric ERCP (EDGE) is a novel way to approach patients with Roux-en-Y gastric bypass (RYGB)[44,45] and avoids the previously described laparoscopic-assisted access into the disconnected portion of the stomach. Importantly, the procedure has gained popularity since 2015[46] because of the ability to use conventional cannulation techniques and equipment. A retrospective multicenter review[47] of 178 patients reported a technical success of 98% (175/178) countered by 4 severe adverse events (SAE) (2.2%) and 10% of patients having a documented persistent fistula (9/90). It has been proposed that the EDGE could be used in patients with a RYGB, of which the details like limb length are unknown, and in patients with a surgically absent gallbladder [48] . A meta-analysis showed comparable rates of success to the laparoscopic assisted ERCP [45] . The significantly higher rates of technical success justify future comparative study of OAE and DBE ERCP with the EDGE procedure. The challenge for any prospective multicenter comparison will be that the EDGE can be done in 2 sessions [45] . The EUS placement of a transluminal stent, and then a second procedure at a follow-up interval to perform the ERCP. Although an EDGE procedure can be done at the time of LAMS placement, stent migration and free perforation can occur and most endoscopists wait 4-6 weeks prior to proceeding to ERCP.

The main indication for ERCP is choledocholithiasis[49] which can cause cholangitis, biliary obstruction, and pancreatitis. For routine stones < 1 cm, a sphincterotomy with stone extraction using a balloon or basket is performed. Large bile duct stones present a particular challenge for safe and complete removal [50] . Recent guidelines have suggested performing a sphincterotomy and then a large balloon dilation over a sphincterotomy alone[51] for large stones. In a systematic review and meta-analysis, patients were more likely to have complete clearance of large stones (≥ 1 cm) OR 2.8, 95%CI: 1.4-5.7, I 2 26% if a balloon dilation was performed after a sphincterotomy (Figure 3) .

Cholangioscopy is ideal for complex lithotripsy because of the ability to visualize the stone and introduce either a laser lithotripsy or electrohydraulic lithotripsy August 16, 2021

Volume 13 Issue 8 catheter [52] . Observational studies have reported procedural success in stone cases up to 92% with single operator cholangioscopy [53] . However, prior randomized controlled trials had not shown a significant difference between large balloon sphincteroplasty and cholangioscopy guided lithotripsy [54] . In a randomized comparison of large balloon sphincteroplasty with single-operator cholangioscopy guided lithotripsy, the proportion of ductal clearance was 72 

Cholangioscopy has progressed significantly since the transition from a dual-operator to a single-operator cholangioscope [52] . With the advent and proliferation of access to single-operator cholangioscopy, sensitivity for diagnosis of obstructive biliary pathology has improved. Cohort studies have shown adequate tissue for diagnostic assessment in 88% of patients with a biopsy performed with cholangioscopy [53] . A recent randomized multicenter trial confirmed higher first sample sensitivity with cholangioscopy compared to standard brushings (68.3% vs 21.4% P < 0.01) in patients with indeterminate biliary strictures [56] . Their data showed that the addition of the visual impression by digital single-operator cholangioscopy and direct biopsy had the highest likelihood of diagnosing malignancy in an indeterminate biliary stricture (Figure 4 ). For patients with primary sclerosing cholangitis, additional biopsies for fluorescence in situ hybridization (FISH) has been shown to improve sensitivity of indeterminate biliary strictures [57] . Management of unresectable cholangiocarcinoma has largely been limited to systemic chemotherapy and radiation. Currently, the main role of ERCP in cholangiocarcinoma is treating biliary obstructions with biliary stents. The advent of endoscopic options for unresectable cholangiocarcinoma has provided some hope in this field. Photodynamic therapy (PDT) and radiofrequency ablation (RFA) provide 2 available options for these patients. PDT works to ablate cancer tissue by using a photosensitizer that is activated by laser light. This results in tissue destruction by apoptosis and necrosis [58] . The main adverse event associated with PDT is photosensitivity. A sentinel study showed a survival benefit in patients receiving PDT [59] . A systematic review and meta-analysis published in 2017 by this journal [60] included 10 studies with 402 patients analyzed. The pooled OR for successful biliary drainage, defined as a reduction in bilirubin of 50% or greater at 7 d, was 4.39 (95%CI: 2.35-8.19) when comparing PDT and biliary stenting to biliary stenting alone. Future directions include targeted placement of the photsensitizer. Pullulan acetateconjugated pheophorbide A is a photosensitizer that was successfully incorporated into self-expanding metal stent [61] .

RFA is a local ablative therapy from a bipolar probe using high frequency current. A randomized trial from 2017 compared the outcomes of RFA with biliary stenting or biliary stenting alone [62] . The primary outcome of the study was mean survival time from the first RFA to time of death. In 21 months of follow-up, the mean survival time was significantly higher in the RFA and stent group (13.2 ± 0.6 mo) than if the patient received a biliary stent alone (8.3 ± 0.5 mo, P < 0.001). A previous retrospective comparative trial showed no difference between PDT and RFA in terms of survival rates 

Radiological studies like CT and MRI/MRCP are the primary means of diagnosing chronic pancreatitis and strictures in 2021. However, in the early stages of chronic pancreatitis where the structural changes are limited, a combination of EUS, MRCP with secretin, and pancreatic function tests can be done in patients with high suspicion and risk factors [67] . ERCP is an important treatment option for patients with symptomatic chronic pancreatitis and strictures[68], with main pancreatic duct (MPD) strictures as the most likely to be intervened on. ERCP is recommended in patients with symptomatic, dominant strictures. These are defined as upstream MPD dilatation ≥ 6 mm in diameter, prevention of contrast medium outflow alongside a 6-Fr catheter inserted upstream from the stricture, or abdominal pain during continuous infusion of a nasopancreatic catheter inserted upstream from the stricture with 1 L saline over 12-24 h [69] . Stenting across the pancreatic duct stricture using ERCP decompresses the duct, helps relieve pain, and can result in improvement of exocrine pancreatic function [68] . Multiple studies have shown that stenting in chronic pancreatitis with strictures can improve pain [70] [71] [72] [73] . A large multicenter study of more than 1000 patients followed up for a mean 4.9 years showed long-term success of endotherapy in 86% of August 16, 2021

Volume 13 Issue 8 patients but was lower at 65% in intention to treat analysis [68] . A large meta-analysis involving 16 studies and 1498 patients showed immediate pain relief in 88% and longterm pain relief in 67%. Complication rates for endotherapy were 7.85% [74] . More recently, rendezvous access using transgastric EUS puncture of the pancreatic duct and guidewire placement through a tight stenosis has allowed treatment of previously inaccessible strictures [75] . This is particularly effective in post Whipple patients with a stenotic pancreaticojejunostomy [76] .

Commonly, a single plastic stent is used in pancreatic strictures. Multiple side-byside plastic stents have also been used in treatment refractory strictures which did not respond to a single stent [77] . Newer stents like the fully covered self-expandable metal stents and a biodegradable noncovered self-expandable stents have been evaluated [78, 79] . Preliminary studies with longitudinal follow-up of fully covered self-expanding metal stents (FCSEMSs) in symptomatic main duct pancreatic strictures [79] are promising. In patients with MPD strictures that remained symptomatic after a single plastic stent who were treated with a 6 mm or 8 mm Niti-S Bumpt Stent (Taewoong Medical, Gimpo-SI, South Korea), 89% of patients were asymptomatic after 3 years. Given the technical success of FCSEMS [80] and relative safety [81, 82] , larger studies with long-term data will be performed. An ongoing trial will look at the degree of pain reduction, SAE, and stricture resolution [83] in patients who received a FCSEMS. To date, SEMS in the pancreatic duct in the United States remains investigational.

The indications for pancreatoscopy include direct visualization of strictures, filling defects, and to differentiate benign from malignant intraductal pathology. Pancreatoscopy can be helpful in the management of suspected intraductal papillary mucinous neoplasms as it can diagnose and stage the disease prior to surgical resection [84] [85] [86] . Per oral pancreatoscopy was first demonstrated in 1970s by Kawai et al [87] , but required a second operator, and the technology was limited[88-90]. The first digital SpyGlass™ direct visualization cholangiopancreatoscope (Boston Scientific Corporation, Marlborough, MA, United States) was introduced in 2007. This included a working channel for biopsies and allowed for irrigation [91, 92] . Further iterations had improved digital image quality [93] . The most recent digital version was launched in 2018 and has increased resolution, improved lighting, a retrieval basket, and a retrieval snare. The primary therapeutic indication of pancreatoscopy is direct lithotripsy for pancreatic duct stones [94] . Complication rates post pancreatoscopy have ranged from 3.8% to 12% and mainly include mild pancreatitis [85, [95] [96] [97] .

Chronic calcific pancreatitis is complicated by intraductal pancreatic stones which can be difficult to manage. In symptomatic patients, preprocedure imaging is mandatory to decide on adding extracorporeal shock wave lithotripsy (ESWL) before ERCP ( Figure 5 ). ESWL is indicated if there are larger stones (≥ 5 mm) with ductal obstruction. Previous studies have shown that adding ESWL significantly decreases pain scores, yearly hospitalizations for pancreatitis, and opioid use [98] . A systematic review and meta-analyses of 22 ESWL ERCP studies noted high rates of complete stone fragmentation at 86.3% (95%CI: 76.0-94.0) [99] . The pooled percentage of patients with complete ductal clearance, however was 69.8% (95%CI: 63.8-75.5). This is a August 16, 2021

Volume 13 Issue 8 difficult patient population to manage and overall ESWL resulted in a moderate proportion of patients with complete absence of pain 64.2% (95%CI: 57.5-70.6). At our institution we perform an ESWL and ERCP in the same session ( Figure 5 ). Repeat treatments are arranged based on post treatment symptom burden, interval imaging, and stone burden on repeat pancreatogram. Pancreatic inflammation can cause a pancreatic duct leak with the unfortunate consequences of peripancreatic fluid collection, pseudocyst, walled-off pancreatic necrosis, pancreatic ascites, and fistula formation [100] . Management of pancreatic duct leaks historically involved conservative management including TPN and octreotide as a bridge to surgery. ERCP allows for diagnosis of the leak, transpapillary stent placement, and avoidance of surgery. Fluid collections from a pancreatic leak can be managed with internal luminal drainage and percutaneous drains [101, 102] . Transluminal pigtail stents placed for pancreatic fluid leak in disconnected duct syndrome can be left in indefinitely as removing stents leads to risk of recurrent fluid collection[103].

ERCPs are done for multiple important reasons[1]. Although the most common indication remains choledocholithiasis with or without cholangitis[49], evolving indications include cholangiopancreatoscopy with directed diagnostic and therapeutic procedures. Further training and improvements in practice have allowed for the use of over-tube, laparoscopic surgery-assisted, and EUS-facilitated ERCP[104] in patients who have undergone RYGB for morbid obesity. New developments in technology have allowed for the potential use of SEMS for refractory pancreatic duct strictures and the redesign of a duodenoscopes to include marketing of a disposable scopes to mitigate infectious complications from inadequately reprocessed devices. Despite the tumultuous last year and a half, there continues to be hope in the field of ERCP for managing complex disease.

The Past, Present, and Future of Endoscopic Retrograde Cholangiopancreatography

Single-operator cholangioscopy in patients requiring evaluation of bile duct disease or therapy of biliary stones (with videos)

Complex biliary stones management: cholangioscopy vs papillary large balloon dilation -a randomized controlled trial

Efficacy of Single-Operator Cholangioscopy-Guided Lithotripsy Compared With Large Balloon Sphincteroplasty in Management of Difficult Bile Duct Stones in a Randomized Trial

Digital single-operator peroral cholangioscopy-guided biopsy sampling vs ERCP-guided brushing for indeterminate biliary strictures: a prospective, randomized, multicenter trial (with video)

Advanced cytologic techniques for the detection of malignant pancreatobiliary strictures

Cholangiocarcinoma: endoscopic therapies

Successful photodynamic therapy for nonresectable cholangiocarcinoma: a randomized prospective study

Success of photodynamic therapy in palliating patients with nonresectable cholangiocarcinoma: A systematic review and meta-analysis

Polymeric photosensitizer-embedded self-expanding metal stent for repeatable endoscopic photodynamic therapy of cholangiocarcinoma

Efficacy and safety of endoscopic radiofrequency ablation for unresectable extrahepatic cholangiocarcinoma: a randomized trial

ERCP-directed radiofrequency ablation and photodynamic therapy are associated with comparable survival in the treatment of unresectable cholangiocarcinoma

Vorinostat-eluting poly(DL-lactide-co-glycolide) nanofiber-coated stent for inhibition of cholangiocarcinoma cells

Endoscopic Palliation for Biliary and Pancreatic Malignancies: Recent Advances

Feasibility and efficacy evaluation of metallic biliary stents eluting gemcitabine and cisplatin for extrahepatic cholangiocarcinoma

Chronic pancreatitis

Endoscopic treatment of chronic pancreatitis: a multicenter study of 1000 patients with long-term follow-up

Endoscopic treatment of chronic pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) Guideline -Updated

Endoscopic pancreatic stent drainage in chronic pancreatitis and a dominant stricture: long-term results

Long-term results of pancreatic stents in chronic pancreatitis

Long-term outcome after pancreatic stenting in severe chronic pancreatitis

Stenting in severe chronic pancreatitis: results of medium-term follow-up in seventy-six patients

Efficacy of Endotherapy in the Treatment of Pain Associated With Chronic Pancreatitis: A Systematic Review and Meta-Analysis

EUS-guided pancreatic drainage for pancreatic strictures after failed ERCP: a multicenter international collaborative study

An international multicenter study comparing EUS-guided pancreatic duct drainage with enteroscopy-assisted endoscopic retrograde pancreatography after Whipple surgery

Multiple stenting of refractory pancreatic duct strictures in severe chronic pancreatitis: long-term results

A biodegradable non-covered self-expandable stent to treat pancreatic duct strictures in chronic pancreatitis: a proof of principle

Fully covered self-expandable metal stents to dilate persistent pancreatic strictures in chronic pancreatitis: long-term follow-up from a prospective study

Preliminary study of a modified, nonflared, short, fully covered metal stent for refractory benign pancreatic duct strictures (with videos)

Long-term outcomes of 6-mm diameter fully covered self-expandable metal stents in benign refractory pancreatic ductal stricture

Fully covered self-expanding metal stents for refractory pancreatic duct strictures in symptomatic chronic pancreatitis, US experience

Fully Covered Self Expanding Metal Stents (FCSEMS) for Pancreatic Duct Strictures in Patients With Chronic Pancreatitis

Endoscopic diagnosis of intraductal papillarymucinous neoplasm of the pancreas by means of peroral pancreatoscopy using a small-diameter videoscope and narrow-band imaging

Efficacy of peroral pancreatoscopy in the diagnosis of pancreatic diseases

Digital Pancreaticocholangioscopy for Mapping of Pancreaticobiliary Neoplasia: Can We Alter the Surgical Resection Margin?

Cholangioscopy and pancreatoscopy (with videos)

Endoscopic treatment of pancreatic duct stones using a 10F pancreatoscope and electrohydraulic lithotripsy

Is pancreatoscopy of any benefit in clarifying the diagnosis of pancreatic duct lesions?

SpyGlass single-operator peroral cholangiopancreatoscopy system for the diagnosis and therapy of bile-duct disorders: a clinical feasibility study (with video)

Preclinical characterization of the Spyglass peroral cholangiopancreatoscopy system for direct access, visualization, and biopsy

Digital, single-operator cholangiopancreatoscopy in the diagnosis and management of pancreatobiliary disorders: a multicenter clinical experience

Endoscopic retrograde cholangiopancreatography with per oral pancreatoscopy for calcific chronic pancreatitis using endoscope and catheter-based pancreatoscopes: a 10-year single-center experience

Diagnosis and patient management of intraductal papillary-mucinous tumor of the pancreas by using peroral pancreatoscopy and intraductal ultrasonography

Peroral pancreatoscopy for the diagnosis of pancreatic diseases

Role of per-oral pancreatoscopy in the evaluation of suspected pancreatic duct neoplasia: a 13-year U.S. single-center experience

Clinical outcomes in patients who undergo extracorporeal shock wave lithotripsy for chronic calcific pancreatitis

Success of extracorporeal shock wave lithotripsy and ERCP in symptomatic pancreatic duct stones: a systematic review and meta-analysis

Management of pancreatic ductal leaks and fistulae

Disconnected pancreatic tail syndrome: a plea for multidisciplinarity

Endoscopic transpapillary pancreatic stenting for internal pancreatic fistula with the disruption of the pancreatic ductal system

Pancreatic-fluid collections: a randomized controlled trial regarding stent removal after endoscopic transmural drainage

The future of ERCP

Smith TD provided editing and administrative support in the production of this manuscript.

 Volume 13  Issue 8