key: cord-0707791-3u3pzrn2
authors: Rothschild, Ehud; Baruch, Guy; Szekely, Yishay; Lichter, Yael; Kaplan, Alon; Taieb, Philippe; Laufer-Perl, Michal; Beer, Gil; Kapusta, Livia; Topilsky, Yan
title: The predictive role of left and right ventricle speckle-tracking echocardiography in Coronavirus Disease 2019
date: 2020-08-18
journal: JACC Cardiovasc Imaging
DOI: 10.1016/j.jcmg.2020.07.026
sha: f92de75f5f20eb92a58392d63be7b5418082fa08
doc_id: 707791
cord_uid: 3u3pzrn2

nan

A recent study shows that LV ejection fraction (LVEF) is preserved in most patients with COVID-19 infection, but LV diastolic and RV function are impaired 1 . We assessed left and right myocardial systolic function by speckle-tracking echocardiography (STE) in 100 consecutive patients with COVID-19 and analyzed their prognostic value on survival and need for intubation.

All patients had a diagnosis of COVID-19 confirmed by a polymerase-chain-reaction-assay for SARS-CoV-2 and underwent STE examination within 24 hours of admission. Demographic, clinical, and laboratory data were systematically recorded. Patients were risk stratified according to their COVID-19 Modified-Early-Warning-Score (MEWS) score 1 . Routine CT was not done due to the risk of contamination of the CT area. All patients who experienced clinical deterioration (need for intubation or hemodynamic deterioration) underwent repeated STE.

Median time between consecutive measurements was 3.5 (3, 5) days. To reduce exposure and contamination, STE was assessed offline. Non adjusted and adjusted Cox proportional hazards models for mortality or combined event (death or new need for intubation) calculated hazard ratios (HR) for STE parameters. Analysis for survival were obtained for all patients. Analyses for the combined event were done excluding 9 patients who were mechanically ventilated before baseline STE. The ethics committee of the Tel Aviv Medical Center approved the study (IRB number 0196-20-TLV) and voided the requirement of informed consent for the echocardiographic assessment. 

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