key: cord-0706579-zwb1mn7c authors: Walger, Peter; Heininger, Ulrich; Knuf, Markus; Exner, Martin; Popp, Walter; Fischbach, Thomas; Trapp, Stefan; Hübner, Johannes; Herr, Caroline; Simon, Arne title: Children and adolescents in the CoVid-19 pandemic: Schools and daycare centers are to be opened again without restrictions. The protection of teachers, educators, carers and parents and the general hygiene rules do not conflict with this date: 2020-05-28 journal: GMS Hyg Infect Control DOI: 10.3205/dgkh000346 sha: 524ac367a39f97d3ed0f00776ce95a516a0b0c3b doc_id: 706579 cord_uid: zwb1mn7c In the opinion of the medical societies of hygiene and pediatrics undersigning the present statement, the analyses published to date regarding transmission of SARS-CoV-2 and the course of CoVid-19 show that children play a much less significant role in the spread of the virus than do adults. According to the findings available to date, not only do children and adolescents less frequently fall ill with CoVid-19, they also generally become less severely ill than do adults. The vast majority of infections in children and adolescents are asymptomatic or oligosymptomatic. Even the first analyses from China demonstrated that children and adolescents play a subordinate role in the transmission of the virus – not only to other children and adolescents, but also to adults. Taking into account regional infection rates and available resources, daycare centers, kindergartens and elementary schools promptly should be reopened. For children, this should be possible without excessive restrictions, such as clustering into very small groups, implementation of barrier precautions, maintaining appropriate distance from others or wearing masks. A factor more decisive than individual group size is the issue of sustaining the constancy of respective group members and the avoidance of intermixing. Children can be taught basic rules of hygiene such as handwashing and careful hygiene behavior when coming into contact with others during mealtimes and/or when using sanitary facilities. Independent of the prevention measures implemented for children and adolescents, the protection of teachers, educators and caregivers is crucial, (e.g., the maintenance of appropriate distance from others, use of medical masks, situation-dependent hand disinfection, when necessary, supported by regular pool testing). Children over the age of 10 and adolescents up to school graduation age are more capable of actively understanding and conforming to specific hygiene rules. For this group, maintaining appropriate distance from others (1.5 meters), wearing a mouth-and-nose protection (whenever they are not sitting in their assigned classroom seats) and consistent education regarding the basic rules of infection prevention may provide increased options for normalizing teaching activities. Children and adolescents suspected of infection with SARS-CoV-2 should be tested immediately in order to either confirm or rule out such an infection. Evidence of individual infections in children or students must not automatically lead to the closure of the entire daycare center or school. A detailed analysis of the chain of infection is a prerequisite for a balanced approach to infection control. The opening of schools and children’s facilities should be accompanied by specifically structured, model surveillance studies that further clarify outstanding questions about infectious disease events and hygiene control. These prospective, concomitant examinations will be essential for the purpose of evaluating and verifying the effectiveness of the required hygiene measures. actively understanding and conforming to specific hygiene rules. For this group, maintaining appropriate distance from others (1.5 meters), wearing a mouth-and-nose protection (whenever they are not sitting in Professional Association of their assigned classroom seats) and consistent education regarding the basic rules of infection prevention may provide increased options Pediatricians in Germany (bvkj e.V.) for normalizing teaching activities. Children and adolescents suspected of infection with SARS-CoV-2 should be tested immediately in order to either confirm or rule out such an infection. Evidence of individual infections in children or students must not automatically lead to the closure In the context of currently available data, we, the undersigned medical societies, consider the following to be feasible: • Taking into account regional infection rates and available resources, daycare centers, kindergartens and elementary schools promptly should be reopened. For children, this should be possible without excessive restrictions, such as clustering into very small groups, implementation of barrier precautions, maintaining appropriate distance from others or wearing masks. A factor more decisive than individual group size is the issue of sustaining the constancy of respective group members and the avoidance of intermixing. • Children can be taught basic rules of hygiene such as handwashing and careful hygiene behavior when coming into contact with others during mealtimes and/or when using sanitary facilities. This can be done in a playful and age-appropriate way. Based upon current knowledge, the implementation of such instruction, together with the mandatory equipment of all school bathrooms and handwashing sites with sufficient soap dispensers and paper towels would have considerable, positive, long-term effects on the spread of many different contagious pathogens in these facilities. • Independent of the prevention measures implemented for children and adolescents, the protection of teachers, educators and caregivers is crucial, (e.g., the maintenance of appropriate distance from others, use of medical masks, situation-dependent hand disinfection, when necessary, supported by regular pool testing). • If adults with a significantly elevated risk of a complicated course of SARS-CoV-2 infection live in the same household with school-age children, then individualized, creative solutions should be pursued. These should be developed following close medical consultation and with the understanding that they are a matter of personal responsibility. Their aim should be to allow children to visit community facilities. Accordingly, appropriate education and public relations work will be necessary. • Recommendations for contact reduction via regulating size of group assembly, avoiding larger group formations during school recess breaks, during school pickup and drop-off times and in other situations also should take into consideration home settings and extracurricular areas. • Children over the age of 10 and adolescents up to school graduation age are more capable of actively understanding and conforming to specific hygiene rules. For this group, maintaining appropriate distance from others (1.5 meters), wearing a mouth-and-nose protection (whenever they are not sitting in their assigned classroom seats) and consistent education regarding the basic rules of infection prevention may provide increased options for normalizing teaching activities. • In contrast to homes for the elderly, community facilities for children and adolescents do not represent a high-risk environment per se. Therefore, pursuant to individual medical considerations, these facilities also may be visited by children and adolescents with certain underlying diseases. • Children and adolescents suspected of infection with SARS-CoV-2 should be tested immediately in order to either confirm or rule out such an infection. Evidence of individual infections in children or students must not automatically lead to the closure of the entire daycare center or school. A detailed analysis of the chain of infection is a prerequisite for a balanced approach to infection control. • The opening of schools and children's facilities should be accompanied by specifically structured, model surveillance studies that further clarify outstanding questions about infectious disease events and hygiene control. These prospective, concomitant examinations will be essential for the purpose of evaluating and verifying the effectiveness of the required hygiene measures. The recommendations published here are based upon present knowledge and the interpretation thereof by the participating professional societies as of May 19, 2020 . Although a basic matter, it nevertheless should be emphasized that advances in knowledge may lead us to reassess the situation in the coming weeks or months. Correspondingly, this may require us to adjust present recommendations. Among children, infection rates and severity of SARS-CoV-2 infection are low Current data indicate a lower rate of symptomatic infections among children and adolescents than among adults. The majority of children and adolescents with SARS-CoV-2 infection show either no symptoms or else only mild symptoms [1] , [2] , [3] . Severe courses of the disease rarely occur [4] . Although not exclusively, only half of all serious infections affect children with underlying diseases and/or with treatment-related impairments to the immune system [5] . Hospital admission is not always an indicator of disease severity. As Parri To what extent specific medical history and/or underlying disease increase the risk of a complicated course in childhood infections with SARS-CoV-2 is not conclusively known. As an example, pediatric oncologists from the MSK Kids Pediatric Program of the Memorial Sloan Kettering Cancer Center (New York) found no increased rate of complications among 20 pediatric oncology patients who tested positive in the middle of the outbreak there [7] . This confirms the very early results of an international survey published on April 20, 2020 [8] . In a recent report from the pediatric oncology department in Padua, Italy, (a high-prevalence region for COVID- 19) , not a single SARS-CoV-2 case was found in over 500 individual tests, including both patients and accompanying persons [9] . Among all those who tested positive, the percentage of children under 10 years of age so far is between 1 and 2%. Positive rates reach a maximum of 6% by the age of 20 years. In Germany, the proportion of children <10 years was 1.9% and those between 10 and 19 years old was 4.3%. According to the RKI's status report from May 17, 2020 [10] , a total of 174,355 infections were recorded by that date. Of these, 3,295 were under 10 years old and 7,524 were between 10 and 19 years old. Only three deaths had occurred among those between three and 18 years old, and each of these cases had underlying conditions. In Norway, as of March 22, 2020, the percentage of SARS-CoV-2-positive children and adolescents up to the age of 20 was 4%. Due to a high proportion of asymptomatic children with SARS-CoV-2 infection, it may be assumed that this represents an underreporting reporting of cases. The actual infection rate cannot be known beyond doubt. Available results from seroepidemiological studies are not yet sufficient for the purpose of determining the actual infection prevalence among children and adolescents. To pediatricians, it will not be surprising to hear that even minimally symptomatic children can excrete the virus in nasopharyngeal secretions in the same concentration as symptomatic adults [11] , [12] . However, to deduce from this that there may be a higher risk of transmission from children to other persons (and especially to adults) [11] , stands in contradiction to the observation that in most confirmed pediatric SARS-CoV-2 cases, it was an adult contact person (e.g., a parent) who was the original source of infection. Of greater relevance is the fact that in contrast to adults, children do not appear to have elevated virus concentrations in the upper respiratory tract [11] , [12] . Risk of transmission by children seems low -school and daycare center closures are likely to have only a narrow impact on the further spread of infection Numerous findings speak against an increased risk of infection from children. Various investigations, reviews, outbreak and cluster analyses, models analyzing previous influenza pandemics (see below), as well as analyses published in relation to the earlier MERS and SARS-1 coronavirus pandemics, are painting an increasingly convincing picture that, in contrast to their part in influenza transmission, children do not play a prominent role in the disease transmission dynamics of the current CoVid-19 pandemic. Within families, transmission of infection to children usually originates from infected adults [13] , whereas evidence of transmission from an infected child to adults remains lacking. Such transmission events also may exist, but they appear to be of less immediate consequence. The impact of school and daycare center closures on the dynamics of further infection spread of SARS-CoV-2 is estimated to be limited [14] , [15] . Key data used as evidence for the significant role of children in transmission dynamics have been taken from studies of influenza pandemics. Comparable data from coronavirus pandemics do not exist. This further demonstrates the relatively low importance of transmission by children. • [19] . • Iceland: In the context of a study, 6% of the Icelandic population was tested between January 31 and early April 2020 [20] . Three groups were examined: 9,199 persons at high risk (presence of symptoms, positive travel history after a skiing holiday in Austria or Northern Italy, and/or contact with a highrisk person). In this group, the total infection rate was 13.3%, with infection among children <10 years at 6.7%. Following an open invitation to participate in testing (population sample), an additional 10,797 persons were tested by March 13, 2020. In this group, the total infection rate was 0.8%, with infection among children <10 years at 0%. Following a targeted invitation (representative sample for quality comparison purposes), 2,283 persons were additionally tested by April 4, 2020. In this group, the total infection rate was 0.6%. At the beginning of the pandemic's spread in Iceland, travel history (return from ski resorts in Austria and northern Italy) represented the main risk factor. Later, travel history (return from Great Britain) and intra-family transmission were the predominant factors [20] . Children <10 years played almost no role in the transmission dynamics. These data have been further confirmed as part of follow-up testing, during which the overall test rate rose to >15% of the total population. • In an analysis by Swiss scientists regarding current effects of non-pharmaceutical interventions (NPIs) on the number of infections in 20 countries (USA, EU-15, Norway, Switzerland, Canada and Australia) [21] , it was shown that school closures had the second-lowest effect on infection transmission (11%). According to the authors, this finding is consistent with previous literature showing that transmission of SARS-CoV-2 by children has been comparatively low. In this analysis, the closing of event venues (33%) and of businesses belonging to non-critical infrastructure (28%) have had a stronger impact. The factor with the very lowest effect was the generalized contact ban [21] . • Great Britain: Published on April 6, 2020, a systematic review [15] assessed the results of 16 studies that had examined the impact of school closures on coronavirus pandemics. In the SARS-1 outbreaks in China, Hong Kong and Singapore in 2003, school closures showed limited benefit in slowing the spread of the virus. The authors point to a variety of collateral damage (loss of essential labor due to the need for parents to provide childcare; restrictions on learning, sociability and physical activity opportunities for students; and significant psychosocial risks for children who are most vulnerable, including those from low-income families). In the absence of solid data on current effects of the CoVid-19 pandemic, the authors conduct an in-depth examination of findings from influenza pandemics. In contrast to these pandemics, they conclude that the effect of school closures on the CoVid-19 pandemic is likely to be small. Interactions with other factors, (e.g., moment and timing of school closure, parents working from home, additional social mixing, including close contacts with at-risk individuals in the family), must be taken into account. The authors stress the urgent need for meaningful data and describe these findings as a dilemma for policymakers, because decisions about school and daycare center closures are getting made without reliable evidence regarding the effectiveness of such measures. In another model analysis conducted by the CoVid-19 Response Team at Imperial College in London -one conducted in order to evaluate non-pharmaceutical interventions (NPIs) -the authors conclude that school closures only can be understood to have an effect if or when it is assumed that children will play a significant role in transmission dynamics. Their model calculates that school closures have only a very minimal effect on the mortality rate [14] . • With respect to the current CoVid-19 pandemic, the relevance of school closures to transmission dynamics is hereby negated. This is in distinct contrast to the role that such closures may play during influenza pandemics. The longer school closures last, the more considerable the collateral damage they will cause. This must be taken into account [22] , [23] , [24] , [25] , [26] The first results show that 3.6% of those examined had SARS-CoV-2 antibodies in their blood. Of these, 2% were under 20 years old and 4.2% were adults. Dutch health authorities interpret this data as evidence that children play only a minor role in the transmission of CoVid-19 [27] . • In a report by the National Centre for Immunisation Research and Surveillance (NCIRS, Australia, April 26, 2020) which tracked on SARS-CoV-2 infections among students (n=9) and teachers (n=9) from 15 schools in New South Wales (10 secondary schools and 5 primary schools), subsequent transmission to classmates (n=735) and staff (n=128) was investigated. During the school day, index patients had normal contact with others. At the primary schools, 137 students and 31 staff were classified as "close contact persons" (those who had face-to-face contact for 15 minutes and/or who were in the same room for at least two hours). At the secondary schools, there were 598 students and 97 staff. No subsequent SARS-CoV-2 infection became detected in any of the staff examined (teachers, caregivers, etc.). (30% were tested.) Only two other children, (a primary school child and a secondary school student), may have been infected by one of the index patients [28]. • Virus concentrations in the throat and suspected contagion: In a quantitative analysis of the viral load among CoVid-19 patients, no significant age-related differences were found. Based upon nasopharyngeal virus identification from tests following clinical indication, the authors conclude: "… In particular, these data indicate that viral loads in the very young do not differ significantly from those of adults. Based on these results, we have to caution against an unlimited reopening of schools and kindergartens in the present situation. Children may be as infectious as adults." However, given that investigations so far predominantly have focused upon symptomatic children and that the overall number of cases has been small, the admissibility of determining transmission risk based upon quantitative viral load in the upper respiratory tract seems questionable. It also may strike some as unusual that, despite the obvious need for discussion, the warning regarding an "unlimited" reopening of kindergartens and schools already has been emphasized in the article's abstract -even though the epidemiological data and comparisons with analyses of previous coronavirus and influenza pandemics is considered controversial [11] . Interestingly, in an investigation of 23 symptomatic newborns, children and adolescents, L'Huillier et al. (Geneva) come to the same conclusion with respect to quantitative virus detection [12] . Nevertheless, they determine only that transmission through children is possible in principle. • In a systematic analysis of confirmed COVID-19 cases reported to the RKI during the lockdown (since March 16, 2020), Goldstein et al. found there to be a relative increase in prevalence among 15-to 20-year-old adolescents/young adults, as compared to patients who were over 25 years old. The group with the highest relative increase in prevalence was that of 20-to 25year-olds [29] . The authors conclude that 15-to 25- year-olds may be playing an important role in the spread of SARS-CoV-2 infection. However, according to this analysis (during the lockdown), this definitely was not applicable to children under 15 years old [29] . Following in-depth mathematical modelling, the same working group concluded that it may be necessary to maintain social distancing measures until 2022 [30] . In an editorial from The Lancet Child & Adolescent Health [26] , the authors describe the relevance of characteristics particular to adolescence, an age during which insecure tendencies, along with newfound explorations and rebellion against social norms, are part of normal development. These developmental factors should be taken into account during the intermediation and review of prevention measures. This very rare syndrome, which to date only has been provisionally clinically defined [31] , [32] , is temporally associated with SARS-CoV-2 infection in children and appears similar to other childhood hyperinflammatory syndromes, (e.g., Kawasaki Syndrome, Macrophage Activation Syndrome). The syndrome can start with severe gastrointestinal symptoms and become life-threatening if the coronary arteries become affected, (see Kawasaki syndrome) [33] , [34] , [35] . On May 6, 2020, the DGPI, together with the German Society for Pediatric Cardiology, published a first statement on this subject [36] . The Royal College of Paediatrics and Child Health also has published initial guidance on the syndrome's diagnosis and therapy [32] . Closely following the publication of such communications is important for all physicians who are currently treating children and adolescents. This applies to both outpatient and inpatient treatment contexts. The pathogenetic relationship with a previous SARS-CoV-2 infection remains unclear [37] . Suspected cases should be monitored and treated in hospital at an early stage and also reported to the relevant health authorities. The occurrence of this multisystemic hyperinflammatory syndrome remains so rare vis-à-vis the total number of children infected with SARS-CoV-2 that it does not alter the basic conclusions we present here. In the opinion of the medical societies undersigning the present statement, the analyses published to date regarding transmission of SARS-CoV-2 and the course of CoVid-19 show that children play a much less significant role in the spread of the virus than do adults. This conclusion in no way negates the need for carefully conducted, prospective surveillance, supported and accompanied by broad-scale test indications, when schools and daycare centers reopen. However, the present statement should provide key guidance for related socio-political decisions undertaken in the context of pandemic management. According to the findings available to date, not only do children and adolescents less frequently fall ill with CoVid-19, they also generally become less severely ill than do adults. The vast majority of infections in children and adolescents are asymptomatic or oligosymptomatic. Even the first analyses from China demonstrated that children and adolescents play a subordinate role in the transmission of the virus -not only to other children and adolescents, but also to adults. Although it is possible that the risk of transmission from adolescents over 15 years old does not significantly differ from that from adults, aspects relating to compliance with prevention measures nevertheless may play an important role. Especially in children under 10 years of age, current data suggest both a lower rate of infection and a significantly lower rate of contagion. Currently, there is insufficient evidence to explain the cause of this lower virus transmission rate, which should be addressed by follow-up investigations. Even among symptomatic children infected by other respiratory viruses, isolated case evidence shows there to be no significant transmission of SARS-CoV-2 [18] . Because of this, the lower risk of transmission may be related either to the fact that children cough less or that the duration of symptoms is shorter. There is no linear relationship between the viral load detected in the upper respiratory tract and the risk of transmission, since it is the quantity of virus reaching the recipient's mucous membranes that ultimately determines whether or not an infection takes hold. The mounting evidence provided by this data has prompted British scientists to call for schools to be reopened immediately, including for children with pre-existing underlying conditions [24] . In the opinion of these British scientists, governments worldwide should allow all children to return to school, regardless of comorbidity. Although current analyses may provide explanation for why school closures are ineffective in the context of the current CoVid-19 pandemic, detailed monitoring nevertheless will be needed in order to confirm the safety of this approach [21] , [15] . According to the current state of knowledge in Germany, severe CoViD-19 is by no means more common than many other, potentially severe infectious diseases in children -ones that to date have not led to the closure of schools or other children's facilities. Doctors should provide individualized risk assessments and customize decision-making for those at particular risk, such as children who are in their first months following bone marrow or organ transplantation, or those who suffer from severe congenital immune deficiencies. If adults with a significantly elevated risk of a complicated course of SARS-CoV-2 infection live in the same household with school-age children, then individualized, creative solutions should be pursued. These should be developed following close medical consultation and with the understanding that they are a matter of personal responsibility. Their aim should be to allow children to visit community facilities. Upon evaluating the available data regarding the nonmedical consequences of closing community facilities, as well as regarding the infectious disease characteristics of SARS-CoV-2 and the epidemiological situation in Germany, on April 20, 2020, the DAKJ began recommending "... the resumption of school attendance ... for all children and adolescents at the earliest possible date." Here, the DAKJ additionally points out that before or during the closure of community facilities for children and adolescents, the consequences of this action for this group had not been thoroughly discussed. The concerns of those directly affected, along with their advocates, had not been sufficiently heard, an issue which represented a disregard for the fundamental rights of children [22] , [23] , [38] . The authors, who have coordinated consensus finding, would like to express their sincere thanks to the numerous dedicated colleagues from the medical associations who actively contributed to developing the consensus for this statement. [14] . Eine relevante Rolle von Schulschließungen auf die Ausbreitungsdynamik wird für die aktuelle CoVid-19-Pandemie verneint. Hierin wird ein entscheidender Unterschied zur Rolle bei Influenza-Pandemien gesehen. Je länger Schulschließungen andauern, je größer sind die hierdurch verusachten erheblichen Kollateralschäden zu berücksichtigen [22] , [23] , [24] , [25] , [26] [29] . Die gleiche Arbeitsgruppe kam nach einer intensiven mathematischen Modellierung zu dem Schluss, dass Maßnahmen der sozialen Distanzierung möglicherweise bis 2022 nötig sein werden [30] . In einem Editorial aus The Lancet Child & Adolescent Health beschreiben die Autoren die Besonderheit der jugendlichen Altersgruppe, in der Tendenzen der Unsicherheit, aber auch der Neuorientierung und des Aufbegehrens gegen gesellschaftliche Normen zur normalen Entwicklung gehören [26] . Dies sollte bei der Vermittlung und der Überprüfung von Präventonsmaßnahmen berücksichtigt werden. Dieses sehr seltene, bisher nur vorläufig klinisch definierte [31] , [32] , mit der SARS-CoV-2-Infektion bei Kindern zeitlich assoziierte Syndrom ähnelt anderen Hyperinflammationssyndromen im Kindesalter (z.B. Kawasaki Syndrom, Makrophagen Aktivierungssyndrom). Es kann mit schwerwiegenden gastrointestinalen Symptomen beginnen und durch einen Befall der Koronargefäße (siehe Kawasaki) lebensbedrohlich verlaufen [33] , [34] , [35] . Die DGPI hat gemeinsam mit der Deutschen Gesellschaft für Pädiatrische Kardiologie hierzu bereits am 06.05.2020 eine erste Stellungnahme publiziert [36] . Auch das Royal College of Paediatrics and Child Health hat erste Hinweise zur Diagnostik und Therapie herausgegeben [32] . Solche Mitteilungen sorgfältig zu verfolgen ist eine wichtige Aufgabe aller Ärzte, die zurzeit Kinder und Jugendlichen behandeln. Dies gilt sowohl im ambulanten als auch im stationären Behandlungskontext. Der pathogenetische Zusammenhang mit einer vorausgegangenen SARS-CoV-2-Infektion ist noch ungeklärt [37] . Verdachtsfälle sollten frühzeitig stationär überwacht und behandelt sowie an die Gesundheitsbehörden gemeldet werden. Das Auftreten eines solchen multisystemischen Hyperinflammationssyndroms ist in Relation zur Gesamtzahl der mit SARS-CoV-2 infizierten Kinder so selten, dass es an den grundsätzlichen, in dieser Stellungnahme formulierten Schlussfolgerungen nichts ändert. [22] , [23] , [38] . MMWR Morb Mortal Wkly Rep SARS-CoV-2 Infection in a Pediatric Department in Milan: A Logistic Rather Than a Clinical Emergency The role of children in the transmission of SARS-CoV-2 (COVID-19) -a rapid review. Oslo: Folkehelseinstituttet / Norwegian Institute of Public Health Epidemiology of COVID-19 Among Children in China Hospital admission in children and adolescents with COVID-19 -early results from a national survey conducted by the German Society for Pediatric Infectious Diseases (DGPI) [Hospitalisierungen von Kindern und Jugendlichen mit COVID-19 -Erste Ergebnisse eines deutschlandweiten Surveys der Deutschen Coronavirus Infection in Pediatric Emergency Departments (CONFIDENCE) Research Group. Children with Covid-19 in Pediatric Emergency Departments in Italy COVID-19 in Children With Cancer Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment Imperial College COVID-19 Response Team (WHO Collaborating Centre for Infectious Disease Modelling / MRC Centre for Global Infectious Disease Analysis / Abdul Latif Jameel Institute for Disease and Emergency Analytics) School closure and management practices during coronavirus outbreaks including COVID-19: a rapid systematic review. Lancet Child Adolesc Health Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) Saura C; Investigation Team. Cluster of coronavirus disease 2019 (Covid-19) in the French Alps Cluster of COVID-19 in northern France: A retrospective closed cohort study Estimating the burden of SARS-CoV-2 in France Spread of SARS-CoV-2 in the Icelandic Population Impact of non-pharmaceutical interventions on documented cases of COVID-19 Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19) Guidance: Paediatric multisystem inflammatory syndrome temporally associated with COVID-19 Rapid risk assessment: Paediatric inflammatory multisystem syndrome and SARS -CoV-2 infection in children Hyperinflammatory shock in children during COVID-19 pandemic An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study Deutsche Gesellschaft für Pädiatrische Kardiologie (DGPK) Gemeinsame Stellungnahme der Deutschen Gesellschaft für Pädiatrische Infektiologie (DGPI) und der Deutschen Gesellschaft für Pädiatrische Kardiologie und Angeborene Herzfehler (DGPK) Hyperinflammationssyndrom im Zusammenhang mit COVID-19 COVID-19 and Kawasaki Disease: Novel Virus and Novel Case. Hosp Pediatr Gemeinsame Stellungnahme von DGPI und Deutsche Akademie für Kinderund Jugendmedizin (DAKJ) zum aktuellen Umgang mit SARS-CoV-2, dem Erreger von Coronavirus disease-19 (COVID-19) MMWR Morb Mortal Wkly Rep SARS-CoV-2 Infection in a Pediatric Department in Milan: A Logistic Rather Than a Clinical Emergency The role of children in the transmission of SARS-CoV-2 (COVID-19) -a rapid review. Oslo: Folkehelseinstituttet / Norwegian Institute of Public Health Epidemiology of COVID-19 Among Children in China Hospital admission in children and adolescents with COVID-19 -early results from a national survey conducted by the German Society for Pediatric Infectious Diseases (DGPI) [Hospitalisierungen von Kindern und Jugendlichen mit COVID-19 -Erste Ergebnisse eines deutschlandweiten Surveys der Deutschen Coronavirus Infection in Pediatric Emergency Departments (CONFIDENCE) Research Group. Children with Covid-19 in Pediatric Emergency Departments in Italy COVID-19 in Children With Cancer Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment How we deal with the COVID-19 epidemic in an Italian paediatric onco-haematology clinic located in a region with a high density of cases Täglicher Lagebericht des RKI zur Coronavirus-Krankheit-2019 (COVID-19). 17.05.2020 -aktualisierter Stand für Deutschland An analysis of SARS-CoV-2 viral load by patient age Shedding of infectious SARS-CoV-2 in symptomatic neonates, children and adolescents [Preprint]. medRxiv Community Transmission of SARS-CoV-2 at Two Family Gatherings Imperial College COVID-19 Response Team (WHO Collaborating Centre for Infectious Disease Modelling / MRC Centre for Global Infectious Disease Analysis / Abdul Latif Jameel Institute for Disease and Emergency Analytics) School closure and management practices during coronavirus outbreaks including COVID-19: a rapid systematic review. Lancet Child Adolesc Health WHO-China Joint Mission on Coronavirus Disease. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) Saura C; Investigation Team. Cluster of coronavirus disease 2019 (Covid-19) in the French Alps Cluster of COVID-19 in northern France: A retrospective closed cohort study Estimating the burden of SARS-CoV-2 in France Spread of SARS-CoV-2 in the Icelandic Population Impact of non-pharmaceutical interventions on documented cases of COVID-19 Maßnahmen zur Prävention einer SARS-CoV-2 Infektion bei Kindern mit besonderem Bedarf bei der Betreuung in Gemeinschaftseinrichtungen (GE) zu weiteren Einschränkungen der Lebensbedingungen von Kindern und Jugendlichen in der Pandemie mit dem neuen Coronavirus (SARS-CoV-2) Children are not COVID-19 super spreaders: time to go back to school. Arch Dis Child Kinder haben das Recht auf Bildung -Als Überträger von SARS-CoV-2 spielen Kinder eine geringere Rolle als bislang vermutet. Daher sollten die Schließungen von Kindertagesstätten und Schulen neu überdacht werden Pandemic school closures: risks and opportunities Netherlands National Institute for Public Health and the Environment) National Centre for Immunisation Research and Surveillance (NCIRS) Temporal rise in the proportion of younger adults and older adolescents among coronavirus disease (COVID-19) cases following the introduction of physical distancing measures Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19) Guidance: Paediatric multisystem inflammatory syndrome temporally associated with COVID-19 Rapid risk assessment: Paediatric inflammatory multisystem syndrome and SARS -CoV-2 infection in children Hyperinflammatory shock in children during COVID-19 pandemic An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study Deutsche Gesellschaft für Pädiatrische Kardiologie (DGPK) Gemeinsame Stellungnahme der Deutschen Gesellschaft für Pädiatrische Infektiologie (DGPI) und der Deutschen Gesellschaft für Pädiatrische Kardiologie und Angeborene Herzfehler (DGPK) Hyperinflammationssyndrom im Zusammenhang mit COVID-19 COVID-19 and Kawasaki Disease: Novel Virus and Novel Case. Hosp Pediatr Stellungnahme von DGPI und Deutsche Akademie für Kinderund Jugendmedizin (DAKJ) zum aktuellen Umgang mit SARS-CoV-2, dem Erreger von Coronavirus disease-19 (COVID-19) Arne Simon Deutsche Gesellschaft für Pädiatrische Infektiologie (DGPI), Chausseestr. 128/129, 10115 Berlin Children and adolescents in the CoVid-19 pandemic: Schools and daycare centers are to be opened again without restrictions. The protection of teachers, educators, carers and parents and the general hygiene rules do not conflict with this Aus Gründen der Lesbarkeit wird darauf verzichtet, geschlechtsspezifische Bezeichnungen zu verwenden. Es sind immer alle Geschlechter gemeint. The authors declare that they have no competing interests. Die Autoren erklären, dass sie keine Interessenkonflikte in Zusammenhang mit diesem Artikel haben.