key: cord-0702768-rjxwp3pi
authors: Bansal, Sandeep; Agstam, Sourabh; Gupta, Anunay; Gupta, Preeti; Isser, H.S.
title: Continue ACE inhibitors/ ARB’S till further evidence in Coronavirus disease 2019 (COVID-19)
date: 2020-05-07
journal: Indian Heart J
DOI: 10.1016/j.ihj.2020.04.007
sha: 56cc7283d28c9a4a2df7c68c259463de278ee2b8
doc_id: 702768
cord_uid: rjxwp3pi

nan

The Coronavirus disease 2019 (COVID-19) has been declared as a pandemic by world health organization (WHO). In the pandemic of Coronavirus, the consequences of hypertension, heart failure and coronary artery disease have been overlooked. One in every three Indian adults has high blood pressure. 1 We wish to highlight the apprehension of cardiologists and physicians on the use of ACE inhibitors/ARB's in the Indian population who are at risk of COVID-19.

Association of coronavirus with angiotensin converting enzyme 2 (ACE2) has been simplified in figure 1 . The SARS-Cov-2 virus enters the cell through ACE 2 receptor on the lung membrane. ACE 2 predominantly catalyzes the conversion of angiotensin II to angiotensin 1-7, and its lesser action is on conversion of angiotensin 1 to angiotensin 1-9. ACE 2 is present at lung alveolar epithelial cells, heart and kidneys. It is having protective effects on the cardiovascular system by degrading angiotensin II, and acts as a vasodilator.

After entry inside the cell, SARS-Cov-2 replicates inside the cell, and cause down regulation of ACE2. The protective role of ACE 2 vanishes and high levels of angiotensin II in the vascular system causes vasoconstriction, acute lung injury and myocardial injury. 2

Angiotensin-converting enzyme inhibitors (ACEi) inhibits angiotensinconverting enzyme (ACE). ACE catalyzes Angiotensin I to angiotensin II. Few animal (rat) studies showed the beneficial effects of ACEi by upregulating ACE 2 mRNA level. A similar effect had been seen by ARB's by upregulating messenger RNA (mRNA) of ACE2 and increasing ACE 2 level. [3] [4] [5] Contrary to previous studies, recent animal studies showed no effect of ACEi/ARBs on ACE2 gene expression. 6 Likewise, human studies of ACEi/ARB's showed conflicting results. [7] [8] [9] In SARS-Cov-2, ACE2 acts as a receptor for the entry of viruses inside the cell. Theoretically, upregulation of ACE2 by ACE i/ARB's helps the entry of virus inside cell; however, no study showed the deleterious effect of ACEi/ARB's in Covid-19 patients or causal relationship among ACEi/ARB's with COVID-19. 10 There is robust evidence of the mortality-lowering effects of ACEi / ARB's in heart failure and postmyocardial infarction. Sudden discontinuation of heart failure therapy leads to precipitation of heart failure. Similarly, ACEi / ARB's, are part of the standard therapy in hypertension, and sudden withdrawal will cause rebound hypertension. Recent literature firmly emphasizes on the continuation of these drugs . 2, 11 Current evidence doesn't support withdrawal of ACEi /ARB's in the population already on these drugs. We should continue using these drugs to prevent mortality due to heart failure and myocardial infarction, until further research on SARS-Cov-2 interaction with ACEi /ARB's shows a strong reason to stop these drugs. 

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