key: cord-0701854-pf3z7hqe authors: Albahri, Abdulaziz Hussain; Alnaqbi, Shatha Ahmed; Alnaqbi, Shahad Ahmed; Alshaali, Asma Obaid; Shahdoor, Shaikha Mohammad title: Knowledge, Attitude, and Practice Regarding COVID-19 Among Healthcare Workers in Primary Healthcare Centers in Dubai: A Cross-Sectional Survey, 2020 date: 2021-07-28 journal: Front Public Health DOI: 10.3389/fpubh.2021.617679 sha: d2e518ae1aed40da4c39de8d8ff2b151b4a3a683 doc_id: 701854 cord_uid: pf3z7hqe Introduction: The coronavirus disease 2019 (COVID-19) pandemic continues to challenge healthcare services worldwide. Healthcare workers (HCWs) are key to the continued effort to overcome the pandemic. This study aims to evaluate the knowledge, attitude, and practices of HCWs toward COVID-19 in primary health centers in Dubai. Methods: This cross-sectional study was conducted at four primary health centers in Dubai, including two fever clinics, from July 5th to July 11th, 2020. A self-administered online questionnaire was distributed to nurses and physicians working in these centers, which evaluated their knowledge, attitude, and practices regarding COVID-19 and their associations with the participants' demographic factors. A total score of 80% and above constituted a level of sufficiency in each section. Additionally, Mann-Whitney U test and multivariable logistic regression were used to analyze the variables. Results: A total of 176 HCWs completed the questionnaire, with a 91.2% (176/193) response rate. They were predominantly female (158/176, 90.0%), nurses (128/176, 72.7%), and non-Emiratis (150/176, 85.2%). While official health organizations were the primary source of information for 91.5% (161/176) of participants, only 38.1% (67/176) reported using scientific journals as one of their sources. Overall, 57.4% (101/176) of participants had a sufficient overall level of knowledge. Moreover, knowledge regarding signs, symptoms, and at-risk groups was generally satisfactory. However, knowledge about the virus, testing, transmission, and the isolation of contacts with positive cases was identified correctly by less than two-thirds of the participants. Half of the participants (89/176, 50.6%) expressed their concern about personally acquiring the infection, 112/176 (63.6%) worried about their relatives acquiring it, and 72/176 (40.9%) expressed some hesitancy to take the COVID-19 vaccine once available. Overall, only 58/176 (33.0%) HCWs had a sufficient overall positive attitude score. Nurses, compared to physicians, and non-Emiratis compared to Emiratis' HCWs, had statistically higher mean scores for attitude (U = 2,212, p < 0.01; and U = 1164.5, p < 0.01, respectively). The majority of participants (156/176, 88.6%) reported acceptable infection control practices. Conclusion: Given the gaps identified in the knowledge and attitude, we recommend further training to improve the skills of primary HCWs, with encouragement to practice evidence-based medicine. Additionally, further exploration regarding vaccine hesitancy is warranted. Results: A total of 176 HCWs completed the questionnaire, with a 91.2% (176/193) response rate. They were predominantly female (158/176, 90.0%), nurses (128/176, 72.7%), and non-Emiratis (150/176, 85.2%). While official health organizations were the primary source of information for 91.5% (161/176) of participants, only 38.1% (67/176) reported using scientific journals as one of their sources. Overall, 57.4% (101/176) of participants had a sufficient overall level of knowledge. Moreover, knowledge regarding signs, symptoms, and at-risk groups was generally satisfactory. However, knowledge about the virus, testing, transmission, and the isolation of contacts with positive cases was identified correctly by less than two-thirds of the participants. Half of the participants (89/176, 50.6%) expressed their concern about personally acquiring the infection, 112/176 (63.6%) worried about their relatives acquiring it, and 72/176 (40.9%) expressed some hesitancy to take the COVID-19 vaccine once available. Overall, only 58/176 (33.0%) HCWs had a sufficient overall positive attitude score. Nurses, compared to physicians, and non-Emiratis compared to Emiratis' HCWs, had statistically higher mean scores for attitude (U = 2,212, p < 0.01; and U = 1164.5, p < 0.01, respectively). The majority of participants (156/176, 88.6%) reported acceptable infection control practices. The world has faced a significant challenge since the outbreak of the novel coronavirus in China in December 2019. Healthcare systems worldwide struggled to cope with the many patients suffering from the novel coronavirus disease 2019 (COVID- 19) , with shortages in medical supplies and medical staff commonplace (1). COVID-19 is an infection caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), which is a beta coronavirus that was first detected in Wuhan, China. It rapidly spread globally, causing more than 34 million infections and over one million deaths by October 2020 (1, 2). The virus spreads primarily via droplets and close contact with infected individuals, with the most common symptoms including fever, dry cough, difficulty breathing, and myalgia (1, 3). However, some less common symptoms exist, such as gastrointestinal upsets and loss of smell or taste (1). The severity of these symptoms varies from person to person, but being elderly and having comorbidities are risk factors for more severe diseases (1, 3) . As of October 2020, treatment is focused on the symptomatic management of patients, with hospitalization required for more severe cases. Additionally, some experimental medications are being trialed with various efficacies (1). Once more, as of October 2020, there is no available vaccine for COVID-19; however, multiple candidates are undergoing clinical trials, which might be available by the end of the year (4) . It is recognized that healthcare workers (HCW) worldwide are at a higher risk of contracting the infection (5, 6) . However, infection control measures, such as hand hygiene, social distancing, and proper donning and doffing of personal protective equipment (PPE), have proven to lessen the spread of the infection (5) . The United Arab Emirates (UAE), and Dubai in particular, saw its first case of COVID-19 infection on the 29th of January 2020. By March, the number of daily reported cases rose steeply, leading the local government to institute a 24-h lockdown in early April. By July 2020, there were over 50,000 reported cases and over 300 deaths (2, 7) . Dubai Health Authority (DHA) had designated two of its 12 primary healthcare centers (PHCs) as fever clinics to direct the flow of suspected COVID-19 patients away from regular clinics. The governmental healthcare system in Dubai before the pandemic was composed of 12 PHCs, where family physicians Abbreviations: CI, confidence interval; COVID-19, coronavirus disease 2019; DHA, Dubai Health Authority; EBM, evidence-based medicine; HCW, healthcare worker; KAP, knowledge, attitude, and practice; PHC, primary healthcare center; PPE, personal protective equipment; SARS-CoV-2, severe acute respiratory syndrome-coronavirus-2; SD, standard deviation; UAE, United Arab Emirates; WHO, World Health Organization. saw patients face-to-face in a mixed system of walk-ins and by appointment. However, during the pandemic, there was a restructuring of the PHCs. One of the centers was converted into a child health and antenatal care center. Another two functioned as 24-h walk-in centers, two fever clinics, and two clean clinics where no fever cases or suspected COVID-19 instances had been seen. The rest remained business as usual, redirecting any suspected COVID-19 cases to the fever clinics and minimizing face-to-face contact by increasing the utilization of the telemedicine service. The purpose of the fever clinics was to redirect any suspected COVID-19 case from any of the other PHCs to a specialist service, where patients would get a COVID-19 PCR swab and overall evaluation about the stability of the case and initiation of symptomatic treatment as indicated. Confirmed positive cases would then be redirected to isolation centers, field hospitals, or main central hospitals based on the severity of the case. By the second half of June, Dubai and the UAE, in general, had passed its first peak of the outbreak, and the lockdown had primarily been eased, with businesses being encouraged to resume work under new normality (7) . By that time, the possibility of a second wave of infection had been speculated by some international experts; therefore, evaluation of the healthcare status in the city was of utmost importance for the preparation to overcome any future related healthcare challenges (8, 9) . HCWs play a crucial role in controlling and managing any potential new outbreaks or resurgence of the infection. Therefore, the current study aimed to evaluate the knowledge, attitude, and practices (KAP) concerning COVID-19 among HCWs working in PHCs in Dubai to overcome any existing or future challenges. Additionally, lessons learned from this study might shed some light and provide guidance to healthcare systems in the region and elsewhere to overcome similar difficulties. This cross-sectional study was conducted between July 5th and July 11th, 2020. The questionnaire was distributed to all family physicians and nurses working in two fever clinics and two regular PHCs in DHA. The focus was on HCWs in direct contact with patient care; thus, other staff, such as pharmacists and radiographers, were excluded. Additionally, nurses and family physicians working in other PHCs were omitted from the study. The selection of the health centers was based on the staff working in these centers being more stable throughout the first outbreak and reflected the practice in a more consistent environment compared to other centers that had variable staff who were shuffled between centers and responsibilities during that period. The sample size was calculated using the CDC Epi Info v7.2.4 software (accessible at: https://www.cdc.gov/epiinfo/) using a single population proportion formula with the assumptions of 95% confidence level, 3% margin of error, 50% proportion of insufficient knowledge, and a total population of 193 HCWs practicing in the four health centers. Accordingly, the minimum sample size required for the study was 164. An online-based, self-administered questionnaire was constructed based on a literature review of previously published relevant questionnaires and in keeping with the World Health Organization (WHO) recommendations (1, 3, 10-16). The questionnaire was comprised of four sections: demographic data, knowledge, attitude, and practice sections. The demographic section asked the participants for their gender, age, nationality, profession and professional experience, workplace, and sources of COVID-19 information. The knowledge section had 15 questions that assessed the participants' knowledge on COVID-19 etiology, signs and symptoms, treatment and management, prevention, transmission, and risk factors. Each question had the answer options of true, false, or I don't know. Only the correct answer was given a score of 1; all other answers scored 0. Therefore, the total score for the section ranged from 0 to 15. The attitude section had seven questions, evaluating the participants' level of fear from COVID-19, their willingness to take preventive measures, help on the frontlines, be isolated if infected, and their confidence in beating the pandemic. Only the single answer that indicated a positive attitude was given a score of 1; other answers scored 0, with a total score ranging from 0 to 7 for the entire section. Finally, the practice section consisted of six questions evaluating the participants' infection control measures during the outbreak. Measures that were always practiced were given scores of 1; otherwise, they scored 0. Accordingly, the maximum score for this section was 6. To have a sufficient score in each section, Bloom's cutoff point of 80% was selected (17) . Therefore, a score of 12 and above was considered having sufficient knowledge, 5.6 and above was a positive attitude, and 4.8 and above was good infection control practice. While some studies set the sufficient score at 70%, we used a more stringent criterion because of the seriousness of the disease and the importance of having a higher degree of knowledge, attitude, and practice to protect the staff, patients, and the community. The questionnaire was piloted on 40 healthcare professionals and further modified to suit the local setting. Results from the pilot study were excluded from the final analysis. Face and content validities were examined by specialists in the field. A sample of the questionnaire is provided in the Supplementary Material. The link to the online questionnaire was forwarded to the managers in charge of each health center, and they were asked to distribute it to all of their relevant staff via email or online messaging services. The link contained an explanatory page of the study and an informed consent form; once accepted, the participant was taken to the questions section to be completed. Data were analyzed using GraphPad Prism v8.4.3, and Mann-Whitney U-test was used to evaluate the association between the demographic variables and the mean scores of the KAP. Pearson's correlation was used to assess the correlation between the knowledge score and the attitude and practice scores. Fisher's exact test was used to evaluate differences in knowledge between fever and regular clinics. Multivariable logistic regression was used to assess the association between the demographic variables and each character in the attitude and practice sections. Alpha <0.05 was deemed statistically significant. Raw data for the results are accessible at: https://figshare.com/s/ 27f23a6fd98149070a67. The DHA Scientific Research Ethics Committee approved this study (reference number: DSREC-06/2020_34). Participation in the survey was voluntary, and online informed consent was obtained before participation in the study. The mean score for the knowledge section was 11.78 (SD = 1.34), with only 101/176 (57.4%) of participants having sufficient knowledge at a cutoff point of 80% of the total score. The data for each question is summarized in Table 2 . The least correctly answered question was regarding the diagnosis of the illness using PCR. The test detects the RNA of the virus and not its proteins, with only four participants selected the correct answer. The other least scored questions were (with the correct answer for each being false): the period of observation for a contact with a confirmed case being 28 days, the name of the virus being SARS-CoV-1 instead of SARS-CoV-2, and that early antibiotic use shortened the duration of the illness, with 36.9% (65/176), 44.9% (79/176), and 63.1% (111/176), answering the questions correctly, respectively. Additionally, only 80.7% (142/176) answered correctly that wearing a mask by the general public could prevent them from acquiring the infection. All other knowledge questions were answered correctly by at least 89.2% (157/176) of participants, as summarized in Table 2 . When comparing individual items in the knowledge section between fever and regular clinics, there was no statistically significant difference between the two groups except for the question that general mask use by the public could protect one from acquiring the disease, with a higher proportion of participants in the fever clinic answering the question correctly [87.4% (76/87) vs. 74.2% (66/89), respectively, p < 0.05], as detailed in Table 3 . The total knowledge score had a statistically significant association with nationality (U = 1,471, p < 0.05), with Emiratis having a higher mean score (mean = 12.27, SD = 1.15) vs. non-Emiratis (mean = 11.70, SD = 1.36). Additionally, physicians had a statistically significant higher score compared to nurses (U = 2338.5, p < 0.05), with a mean of 12.19 (SD = 1.48) vs. 11.63 (SD = 1.25) for nurses. There were no associations with other demographic variables (data summarized in Table 4 ). Moreover, there were no statistically significant correlations between the knowledge scores and the attitude or the practice scores ( Table 6 ). Only 33% (58/176) of participants had a sufficient overall attitude score, with a mean score of 4.80 (SD = 1.43) for all the participants ( The attitude score had a statistically significant association with nationality (U = 1164.5, p < 0.01) and profession (U = 2,212, p < 0.01), with non-Emiratis and nurses having higher mean scores, as shown in Table 4 . Multivariable logistic regression demonstrated that physicians and HCWs working in fever clinics were less willing to be isolated in a healthcare facility if they got infected compared to nurses and HCWs in regular clinics (aOR: 0.25, 95% CI: 0.08-0.80, p < 0.05; aOR: 0.27, 95% CI: 0.10-0.67, p < 0.01, respectively). Moreover, Emirati HCWs were less willing to be vaccinated against COVID-19 than HCWs from other nationalities (aOR: 0.23, 95% CI: 0.06-0.76, p < 0.05). Man-Whitney U-test, with p < 0.05 indicating statistical significance. * P < 0.05 and ** P < 0.01. Table 5 summarizes the logistic regression analysis of the attitude variables. Correlation analysis between the attitude scores and the practice scores showed a positive but weak correlation between the two [r (174) = 0.2, 95% CI: 0.03-0.32, p < 0.05], suggesting that participants with higher positive attitude scores were more likely to also score higher in the practice part ( Table 6) . However, since the association was weak, and both sections were pure reporting of the participants rather than actual auditing in the field, this finding warrants further exploration in future studies. The majority of participants (156/176, 88.6%) reported an acceptable practice, with only 20/176 participants scoring below the 80% total cutoff point ( Table 2 . Non-Emiratis and nurses, in general, had higher mean scores for practice compared to Emiratis (U = 1,461, p < 0.05) and physicians (U = 2,330, p < 0.05), as summarized in Table 4 . Compared to nurses, physicians were less likely to participate in a training program (aOR: 0.37, 95% CI: 0.14-0.99, p < 0.05) and less likely to report a proper doffing of PPE (aOR: 0.19, 95% CI: 0.04-0.83, p < 0.05). Likewise, HCWs at fever clinics were less likely to report a proper doffing of PPE (aOR: 0.18, 95% CI: 0.04-0.65, p < 0.05). Our study highlights several challenges facing HCWs working in primary healthcare centers in Dubai during the COVID-19 pandemic. First, the knowledge gap is quite vast, with only 57.4% (101/176) scoring a sufficient level of knowledge, even though the country had already passed the peak of the first outbreak wave by the time the study was conducted (7) . In additional research in Vietnam, HCWs in a hospital setting exhibited a higher knowledge level (over 88% had adequate knowledge) even though it was conducted earlier in the pandemic (11) . While direct comparison cannot be made confidently between the two studies, as Vietnam has a different healthcare setting and social background, and their research was conducted at a hospital level, we still speculate some of the differences in knowledge stem from two main reasons: one is the rapid change in recommendations and evidence related to the disease (18) . Second is the infodemic phenomenon that has led to a campaign of misinformation and anecdotal evidence that is widespread amongst the public and HCWs (19) (20) (21) . For instance, we recognize a pattern in the knowledge section that when the participants were asked about facts that either kept on changing as the evidence changed or had misinformation circulating related to it, they did not score high enough. Such examples include wearing masks by the general public, the isolation period for contact with a positive case, and antibiotic use as a treatment. At the beginning of the pandemic the recommendation was not to wear masks by the general public unless the person was symptomatic to help save PPE shortages. However, afterward, there was an emphasis locally and by the WHO about the importance of wearing face masks by the public to curtail the disease's spread by positive asymptomatic cases (22, 23) . The quarantine of contacts and incubation period of the virus was not very clear to start with either. Subsequently the recommendation was 10-14 days in most countries, including the UAE (3, 24, 25) . Finally, antibiotics, such as azithromycin, were not supported by any substantial evidence but were encouraged by various HCWs in different parts of the world (26, 27) . Nevertheless, recent evidence refuted the benefits of such treatments (28) . We speculate that the evidence-based medicine (EBM) culture is weak amongst the HCWs population studied. Only 38.1% reported using scientific journals or research papers as their primary sources of information during the outbreak. Previously published data on EBM also highlighted such a weakness in the PHC sector in Dubai (29) . This is alarming, as HCWs are considered frontline fighters against the disease and the misinformation campaign. The weaker their knowledge, the less likely they will be able to fight this misinformation. Furthermore, they could be the ones who are unintentionally spreading it. For example, when asked about the scientific name of the virus, which the WHO finalized, only 45% recognized that SARS-CoV-1 was incorrect and should have been SARS-CoV-2. Additionally, only 4 HCWs recognized that PCR does not analyze the virus's protein but rather its genetic material. This again is noteworthy, as two of the studied clinics were fever clinics that do COVID-19 PCR swabs daily. In the attitude section, only 33% participants scored an adequate total score compared to similar studies (11, 16) . Primarily, there was extreme concern about being infected or having a relative being infected by the virus. This type of concern was further addressed and highlighted in the literature by Shanafelt et al. as a multifactorial issue involving matters related to the organization's preparedness and its ability to protect its workforce's physical and mental well-being (30) . Moreover, there were hesitations amongst the study subjects regarding taking the vaccine, being isolated in a healthcare facility if infected and agreeing that the pandemic would be successfully controlled. Once more, as highlighted earlier in the section, having such a low attitude makes it challenging to fight the widespread circulating misinformation about the disease, and such HCWs might unintentionally help in exacerbating the spread of such misinformation. Additionally, they might challenge maintaining a healthy workforce in the prolonged fight of the pandemic. Furthermore, with about 41% of the participants showing some degree of hesitation to take the vaccine, this highlights an important area for further exploration to overcome any future challenges in implementing a successful vaccination campaign, as highlighted by various studies in developing and developed countries (31) (32) (33) (34) . On the other hand, there was a greater positive willingness to continue fighting on the frontlines, with about 94% willing to do so in the future. This is a reassuring sign if further resurgence of the infection occurs in the future, as predicted by some experts (8, 9, 35) . While the HCWs in the study reported a high level of good infection control practice measures, they also highlighted the need to increase training programs regarding the disease during this pandemic, with only 72% (126/176) always participating in such programs during the outbreak. With further training and increased competency of HCWs, the staff 's anxiety likely would be further alleviated, and the healthcare outcomes of the patients would be improved (30) . Our study exhibits an inherent recall bias that is expected in most cross-sectional questionnaire-based studies. Additionally, the attitude and practice sections could have been captured more accurately via interviewing the participants. The practice section does not necessarily reflect the actual practice of the HCWs, as they are reports by the participants. Thus, observing and auditing the participants' approach would provide further depth in this section. Our study noted that male participants constituted only 10% (18/176) of the study subjects, and Emirati participants were primarily physicians. This is not a pure selection bias issue but an actual reflection of the constituents of the workforce that makes the public primary healthcare sector in Dubai with a predominantly female workforce. Consequently, the results might not accurately reflect the views of the male HCWs or the Emirati nurses' KAP. Furthermore, the study only evaluated the views of family physicians and nurses in only four PHCs. As such, extrapolating the data to other HCWs and centers should to be taken into consideration. Moreover, the study was not powered to detect the differences between the various groups. As the world continues to battle the pandemic of COVID-19, evaluating the current KAP of the healthcare workforce regarding COVID-19 is paramount for winning this battle. The present study assessed the KAP of HCWs in the PHC sector in Dubai in fever and regular clinics. Significant gaps were identified regarding the virus's name, the type of testing, the transmission, and the isolation period of contacts with positive cases. Knowledge regarding signs and symptoms and the at-risk groups was generally satisfactory. Promotion of EBM culture amongst the HCWs in the PHC sector is greatly recommended to overcome the challenge of the infodemic phenomenon associated with COVID-19 and the related misinformation that is widely circulating worldwide. There was a significant level of anxiety amongst the study participants regarding contracting the disease themselves or their relatives and some degree of hesitancy to take the vaccine once it became available. We recommend that further training be provided to the HCWs to increase their confidence in battling the current outbreak and preparing them for any future surges of the disease. Vaccination hesitancy warrants further study and evaluation to overcome any additional obstacles by the time the vaccine becomes available. While most of the study participants reported performing satisfactory infection control measures, physical auditing needs to be evaluated at the workplace to ensure that corrective actions are in place and are being followed. Findings from our study warrant further similar exploration in the region and developing countries as similarities in the healthcare system setting and challenges might be shared. Not only might they apply to the current COVID-19 pandemic, but they will also help the region in overcoming and effectively handling any future pandemics and health emergencies. Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review World Health Organization. WHO Coronavirus Disease (COVID-19) Dashboard Available online at Developing a SARS-CoV-2 vaccine at warp speed Supporting the health care workforce during the COVID-19 global epidemic Coronavirus disease 2019 (COVID-2019) infection among health care workers and implications for prevention measures in a tertiary hospital in Wuhan, China Public health strategies for the gradual lifting of the public sector lockdown in Jordan and the United Arab Emirates during the COVID-19 crisis First-wave COVID-19 transmissibility and severity in China outside Hubei after control measures, and second-wave scenario planning: a modelling impact assessment Risk of a second wave of Covid-19 infections: using artificial intelligence to investigate stringency of physical distancing policies in North America Knowledge, attitudes, and practices towards COVID-19 among Chinese residents during the rapid rise period of the COVID-19 outbreak: a quick online cross-sectional survey Knowledge and attitude toward COVID-19 among healthcare workers at District 2 Hospital Knowledge and attitudes towards middle east respiratory syndrome-coronavirus (MERS-CoV) among health care workers in South-Western Saudi Arabia Knowledge, attitude, and practice towards coronavirus disease 2019 (COVID-19) among medical students: a cross-sectional study A crosssectional survey of knowledge, attitude and practice associated with COVID-19 among undergraduate students in China Knowledge, awareness and practice of health care professionals amid SARS-CoV-2, corona virus disease outbreak Knowledge, attitude, and practice regarding COVID-19 among healthcare workers in Henan Evidence-based medicine and COVID-19: what to believe and when to change Corona virus (Covid-19) "infodemic" and emerging issues through a data lens: the case of china Infodemic and the spread of fake news in the COVID-19-era Understanding Infodemic and Misinformation in the Fight Against COVID-19 Rationale for universal face masks in public against COVID-19 Covid-19: should the public wear face masks? Evidence from two cases of asymptomatic infection with SARS-CoV-2: are 14 days of isolation sufficient? Novel Coronavirus (COVID-19) Potential use of hydroxychloroquine, ivermectin and azithromycin drugs in fighting COVID-19: trends, scope and relevance Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: a retrospective analysis of 1061 cases in Marseille, France Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19 Evaluating factors affecting the implementation of evidence based medicine in primary healthcare centers in Dubai Understanding and addressing sources of anxiety among health care professionals during the COVID-19 pandemic Planning for a COVID-19 vaccination program A future vaccination campaign against COVID-19 at risk of vaccine hesitancy and politicisation Mistrust in biomedical research and vaccine hesitancy: the forefront challenge in the battle against COVID-19 in Italy A Descriptive-multivariate analysis of community knowledge, confidence, and trust in COVID-19 clinical trials among healthcare workers in Uganda COVID-19: are we ready for the second wave? Disaster Medicine And Public Health Preparedness The studies involving human participants were reviewed and approved by Dubai Scientific Research Ethics Committee at Dubai Health Authority. The patients/participants provided their written informed consent to participate in this study. AHA was responsible for data analysis and writing the draft of the paper. All authors contributed to the review of the draft manuscript, subsequent modifications, design of the study, and data collection. All authors reviewed the manuscript before submission and approved the final version. The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fpubh. Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.