key: cord-0701205-ddo2b74g authors: Tonetti, Tommaso; Zanella, Alberto; Pizzilli, Giacinto; Irvin Babcock, Charlene; Venturi, Sergio; Nava, Stefano; Pesenti, Antonio; Ranieri, V Marco title: One ventilator for two patients: feasibility and considerations of a last resort solution in case of equipment shortage date: 2020-04-23 journal: Thorax DOI: 10.1136/thoraxjnl-2020-214895 sha: af9871c274676d16eec843a7372895ca152973f5 doc_id: 701205 cord_uid: ddo2b74g nan The present emergency caused by the spread of the Covid-19 infection is putting enormous pressure on the healthcare systems worldwide and especially on intensive care units (ICUs). One of the main fears in this regard is that we may run out of ventilators, a possibility which is getting more and more likely as the pandemic spreads throughout the world and the ICUs are overloaded with ventilated patients. Many authors have already investigated the possibility of manipulating a ventilator circuit in order to ventilate up to four patients with a single machine. Neyman and Ervin first performed a bench study demonstrating the technical feasibility of ventilating four patients with one ventilator and one modified circuit. 1 The same circuit configuration was used in 2008 by Paladino et al in an animal model, resulting in substantial differences in oxygenation and decarboxylation between subjects during the ventilation period. 2 In 2012 Branson et al tested in vitro the Neyman and Ervin system simulating different conditions of compliance and resistance between the simultaneously ventilated test lungs. They observed wide variability in measured tidal volume (Vt) and end-expiratory lung volume, so they concluded that the technique should be avoided because of potential danger. 3 Accordingly, the authors argued that the stockpiling of ventilators should be the firstline solution when massive emergencies are forecast; only after their depletion, strategies such as the 'double circuit' should be implemented for the shortest possible duration. 4 5 On 20 February 2020, the first case of Covid-19 emerged in the Lombardy region, northern Italy. As of 17 March, a total of 1069 patients had been admitted to ICUs in Lombardy, with a total of 1202 ICU beds available (after a significant expansion from the 720 beds available pre-crisis). 6 By this time, a potential problem of ventilator shortages began to emerge because of the further spread of the virus in other regions of Italy. Great efforts have been put into place by institutions and industries to provide more ventilators for hospitals, but there is still a high potential for a supply-demand mismatch. Therefore, we assembled, tested and proposed for production a simple circuit comprising tubing and accessories that are easily available in any intensive care/operating room setting. Indeed, one just needs two regular 'wye' breathing circuits, two 'T' connectors, and four heat and moisture exchanger (HME) filters to build this system (see figure 1online supplementary file 1, online supplementary file 2). The two T pieces are connected to the inspiratory and expiratory ports of the ventilator (figure 2). We preferred to interpose one HME filter in each expiratory limb (and not one for the entire expiratory circuit) in order to reduce total circuit resistance. At the end of each wye a patient is connected by interposing one HME filter. Total length of the tubing is 9.6 m, and each patient can be located at ~2 m from the ventilator. We tested the circuit on a turbine ventilator (SIARETRON 4000 T, Siare Engineering International Group, Crespellano-Valsamoggia, Italy) connected by a two-patient circuit (Intersurgical SpA, Mirandola, Italy) to two test lungs (Model 5601 -Michigan Instruments Inc, Grand Rapids, MI, USA). We set ventilation for two patients of 80 kg of predicted body weight (PBW) targeting 6 mL/kg Vt at a respiratory rate (RR) of 20/min with an inspiratory: expiratory (I:E) ratio of 1:1 and a fraction of inspired oxygen (FiO 2 ) of 100%. Positive end-expiratory pressure (PEEP) was set at 15 cmH 2 O and initial inspiratory pressure (Pinsp) at 10 cmH 2 O. We performed an initial 15 hour test with similar conditions between the two simulated patients (static compliance of the respiratory system (Cstat) 50 mL/cmH 2 O and airway resistance (Raw) 5 cmH 2 O/L/sec); in pressure control mode (Pinsp 11 cmH 2 O, PEEP 14 cmH 2 O, RR 20 beats/ min), measured delivered Vt was 953 mL, while the patients received 470 mL each. We then performed two more tests: shortages. A critical point is to match patients by compliance and, possibly, by airways resistance. Clinical personnel must remain vigilant, in order to recognise any possible sign of hypoor overventilation, and must be ready at any time to start manual bag ventilation if any issue would occur. Compared with manual bag ventilation, our technique allows delivery of ventilation, PEEP and FiO 2 with reasonable accuracy, is safer for operators and avoids the need for additional human resources (no 'human ventilator' is constantly needed at the patient's head). Using one ventilator for two patients instead of four (as proposed by some authors) reduces possible logistical issues (bed and ventilator positioning) and problems related to inadequate patient size matching. We can conclude that this simple and easily built circuit can theoretically allow the emergency ventilation of two patients with a single ventilator. However, for a clinical application of this 'extreme' technique, several other factors must be taken into account. Indeed, anthropometric features (body weight and body mass index), respiratory mechanics (lung and chestwall compliances, airway resistances, possible auto-PEEP), physiological variables (complete paralysis, oxygen consumption and carbon dioxide production) and the clinical course of the two connected patients play a major role in determining the quality and quantity of ventilation delivered to each patient. Moreover, monitoring respiratory mechanics in each patient would be impossible or very difficult; however, we cannot neglect the possibility that, besides technical and physiological factors, ethical dilemmas may also arise. 7 Indeed, the most difficult choice during such an emergency would be to either accept a grim triage reality (in which not all patients receive a ventilator) or accept the fact that trying to save two patients with one ventilator could mean harming at least one of them. To the best of our knowledge, no significant evidence is available to date on this topic, but very recently New York-Presbyterian Hospital in the USA published a clinical guideline on this topic. 8 To add to the controversy, however, a very recent consensus statement by several North American scientific societies discourages clinicians from connecting more than one patient to a single ventilator. 7 A single ventilator for multiple simulated patients to meet disaster surge Increasing ventilator surge capacity in disasters: ventilation of four adult-human-sized sheep on a single ventilator with a modified circuit Use of a single ventilator to support 4 patients: laboratory evaluation of a limited concept A single ventilator for multiple simulated patients to meet disaster surge One ventilator multiple patients--what the data really supports Critical care utilization for the COVID-19 outbreak in Lombardy, Italy: early experience and forecast during an emergency response Consensus Statement on Multiple Patients Per Ventilator Columbia University Vagelos College of Physicians & Surgeons -New York-Presbiterian Hospital -ventilator sharing protocol: dual-patient ventilation with a single mechanical ventilator for use during critical ventilator shortages -version 4