key: cord-0697880-6uuovp0a
authors: Agcaoglu, Orhan; Sezer, Atakan; Makay, Ozer; Erdogan, Murat Faik; Bayram, Fahri; Guldiken, Sibel; Raffaelli, Marco; Sonmez, Yusuf Alper; Lee, Yong-Sang; Vamvakidis, Kyriakos; Mihai, Radu; Duh, Quan-Yang; Akinci, Baris; Alagol, Faruk; Almquist, Martin; Barczynski, Marcin; Bayraktaroglu, Taner; Berber, Eren; Bukey, Yusuf; Cakmak, Guldeniz Karadeniz; Canturk, Nuh Zafer; Canturk, Zeynep; Celik, Mehmet; Celik, Ozlem; Ceyhan, Banu Ozturk; Cherenko, Sergii; Clerici, Thomas; Coombes, David Scott; Demircan, Orhan; Deyneli, Oguzhan; Dionigi, Gianlorenzo; Emre, Ali Ugur; Erbil, Yesim; Filiz, Ali Ilker; Gozu, Hulya Ilıksu; Gurdal, Sibel Ozkan; Gurleyik, Gunay; Haciyanli, Mehmet; Kebudi, Abut; Kim, Seokmo; Koutelidakis, Giannis; Kuru, Bekir; Mert, Meral; Oruk, Guzide Gonca; Ozbas, Serdar; Palazzo, Fausto; Pandev, Rumen; Riss, Phillip; Sabuncu, Tevfik; Sahin, Ibrahim; Sakman, Gurhan; Saygili, Fusun; Senyurek, Yasemin Giles; Sleptsov, Ilya; Van Slycke, Sam; Teksoz, Serkan; Terzioglu, Tarik; Tezelman, Serdar; Tunca, Fatih; Ugurlu, Mustafa Umit; Uludag, Mehmet; Villar-del-Moral, Jesus; Vriens, Menno; Yazici, Dilek
title: Management of endocrine surgical disorders during COVID-19 pandemic: expert opinion for non-surgical options
date: 2021-04-11
journal: Updates Surg
DOI: 10.1007/s13304-021-00979-8
sha: 329e8a5b11480e88bfa626fc296d0d8afb289c52
doc_id: 697880
cord_uid: 6uuovp0a

PURPOSE: The COVID-19 pandemic brought unprecedented conditions for overall health care systems by restricting resources for non-COVID-19 patients. As the burden of the disease escalates, routine elective surgeries are being cancelled. The aim of this paper was to provide a guideline for management of endocrine surgical disorders during a pandemic. METHODS: We used Delphi method with a nine-scale Likert scale on two rounds of voting involving 64 experienced eminent surgeons and endocrinologists who had the necessary experience to provide insight on endocrine disorder management. All voting was done by email using a standard questionnaire. RESULTS: Overall, 37 recommendations were voted on. In two rounds, all recommendations reached an agreement and were either endorsed or rejected. Endorsed statements include dietary change in primary hyperparathyroidism, Cinacalcet treatment in secondary hyperparathyroidism, alpha-blocker administration for pheochromocytoma, methimazole ± β-blocker combination for Graves’ disease, and follow-up for fine-needle aspiration results of thyroid nodules indicated as Bethesda 3–4 cytological results and papillary microcarcinoma. CONCLUSION: This survey summarizes expert opinion for the management of endocrine surgical conditions during unprecedented times when access to surgical treatment is severely disrupted. The statements are not applicable in circumstances in which surgical treatment is possible.

Humanity is experiencing an extraordinary period in which coronavirus disease 2019 has become one of the biggest health issues of the current century. Due to this extraordinary crisis, health systems in many countries have come to a point in which they can deal only with the COVID-19 pandemic, causing many routine surgical procedures to be postponed [1, 2] . Operation room schedules for cancer patients are becoming more contracted as the demand for specific care of COVID-19 patients is increasing in most hospitals. With the escalation of the epidemic, surgical wards are also progressively being reserved for COVID-19 patients. Therefore, hospital beds allocated for COVID-19 patients further decrease other patients' chances for receiving timely surgery [3] [4] [5] .

Endocrine surgical procedures are amongst the most common elective operations in clinical practice. Management of endocrine patients who cannot be treated surgically due to the current circumstances is also an ongoing matter of uncertainty. Therefore, alternative treatment algorithms may be considered valid options. However, there is no evidencebased medical data regarding the management of endocrine disorders in case of an outbreak, such as COVID- 19 .

The pandemic we are going through these days may repeat itself in coming years. Therefore, as specialists on endocrine disorders, we must be ready for the next extraordinary situation. Hence, it is necessary to build a consensus by a group of experts on how to manage endocrine disorders during times like the COVID-19 pandemic.

The purpose of this survey is to clarify the treatment algorithms of basic endocrine scenarios, which would normally require surgery but have to be postponed due to a situation, such as the pandemic, in the perspective of experts in the field.

An expert opinion development procedure was designed using the Delphi method. At first, an open-ended, unstructured, pilot survey was developed and distributed to the multidisciplinary research group including a total of eight endocrinologists and endocrine surgeons. After the verification of this core questionnaire and based on the responses received, a multiple-choice structured survey was designed.

The inclusion criteria of experts were considered, having at least 6 years of general endocrine practice experience, dealing with endocrine patients for at least 50% of his/her daily clinic time, working at a tertiary reference hospital with comprehensive endocrine disorders treatment facilities for a minimum of 5 years, and attending regular multidisciplinary tumor boards every week for a minimum of 5 years. The authors approached prominent members of the European Society of Endocrine Surgeons and Turkish Association of Endocrine Surgery, recognized by their peers through the regular activities of these societies. Every attempt was made to obtain a wide coverage of different countries.

The consensus design consists of recommendations (other than surgery) for different case scenarios including primary and secondary hyperparathyroidism, Graves' disease, pheochromocytoma, adrenal cancer, and thyroid fine-needle aspiration cytology (FNAC) results which normally require surgery based on current guidelines. Experts were requested to vote on the alternatives considered when surgical treatment is not a suitable option for a temporary period. In all the cases presented, the patients were assumed to be otherwise healthy, COVID-19-free, and without any co-morbidity limiting surgery.

All correspondence with the panelists was done by e-mail. The survey consisted of 37 questions and was administered online using Qualtrics ® software link. Questions included demographics and treatment algorithms of most frequent endocrine disorders, which require surgery. A Likert scale from 1 (strongly disagree) to 9 (strongly agree) was used for voting on each question. The results for each recommendation were grouped into three categories including 1-3 (disagree), 4-6 (abstain) and 7-9 (agree).

For any decision to be made, voting on recommendation statements needed to pass through 2 steps. First, quorum needs to be attained and second, any of the endorsement or rejection thresholds of 75% should be met at each round. If the voting on a recommendation did not attain the quorum or pass the threshold for any decision, the situation was regarded as "consensus was not reached". If quorum is attained but votes did not cross the thresholds, the question was included in a second round of voting. During the second round, the same requirements for each decision were sought. If the thresholds were attained at any round, the consensus procedure was regarded as complete for that certain recommendation. On the other hand, if a decision had not been reached for a recommendation at the end of second round, the result for that recommendation was regarded as "consensus not reached-inconclusive".

No statistical analysis was used. Results of each voting minimum at one round were given as descriptive variable (n: %).

A total of 37 consensus statements on different treatment algorithms were drafted and sent to the experts for voting (Table 1) .

Sixty-seven physicians were nominated as experts according to eligibility criteria. From them, 45 were endocrine surgeons and 22 endocrinologists. The participating countries included Austria, Belgium, Bulgaria, Greece, Italy, the Netherlands, Poland, Russia, South Korea, Spain, Sweden, Switzerland, Turkey, Ukraine, the United Kingdom and USA.

The first round of consensus voting was completed on May 20, 2020. At this round, 64 (94%) panelists responded with their vote; therefore, quorum was attained. Forty-one of them were endocrine surgeons and 23 were endocrinologists. Three statements were endorsed and 28 were rejected. Six recommendations in which consensus was not reached (recommendations no: 1, 6, 10, 24, 27 and 29) were sent to panelists for re-voting on the second round (attendance, n: 56, 83%) completed on May 30, 2020. All six recommendations on the second round were endorsed by the panel. Therefore, nine recommendations were endorsed and 28 were rejected overall. There were no recommendations left without a consensus ( Table 2) .

All recommendations were based on the assumption that necessary surgery cannot be carried out in endocrine patients under the COVID-19 pandemic conditions. The panel members endorsed only dietary changes (low calcium intake + hydration) for 3 months for patients who are diagnosed with symptomatic/asymptomatic primary hyperparathyroidism and are candidate for surgery. Regarding patients who are diagnosed with secondary hyperparathyroidism due to chronic renal insufficiency and are candidate for surgery, experts endorsed only cinacalcet treatment for 3 months. Related to Graves' disease, experts endorsed methimazole ± β-blockers.

For adrenal disorders, while a majority of experts rejected any treatments other than surgery in patients with adrenal cancer, most of them endorsed only α-blocker treatment in patients with pheochromocytoma.

Regarding scenarios after fine-needle aspiration cytology, while panelists endorsed postponing elective operations at least 3-6 months for nodules with Bethesda 3-4 cytologic results and papillary microcarcinomas without pathological lymph node involvement, they rejected all other options other than surgery in patients with a cancer diagnosis (papillary or medullary) or pathological lymph node involvement at the central or lateral neck compartment.

The coronavirus disease 2019 named COVID-19 was first reported in Wuhan, China, then declared a pandemic by the World Health Organization. In a very short period, the pandemic turned into a worldwide crisis and demanded a major reform to the entire world healthcare system. Although COVID-19 patients received their crucial treatments, required to keep them in stable condition, other disorders which are not associated with COVID-19 that also require critical managements and were forced into mandatory deferral until the end of pandemic [1] .

Endocrine disorders which need surgery in normal daily practice were among the leading group of patients who were delayed due to the pandemic. These patients included not only cancer patients, but also benign conditions, such as pheochromocytoma or Graves' disease, which can be life-threatening with prolonged surgical delays. Regarding the determination of patients who need urgent operations or those that can be safely deferred, many groups from other specialties including hepatobiliary, colorectal, and visceral surgeries reported guidelines or expert opinions [4] [5] [6] [7] . However, for endocrine disorders, there is still scant All questions below were evaluated using a 9-scale Likert scale 1 to 9: Strongly Disagree to Strongly agree and limited data in the literature [8] . Thus, there is no national or international case-based expert consensus or guidelines for endocrine disorders outlining alternative procedures for the conventional surgical algorithms. We believe that situations, such as this pandemic, may reoccur, and we should always be ready to manage these disorders with medical or alternative treatments in which elective surgeries are mandatorily postponed due to high risk. The current consensus aims to methodize a guideline for endocrine specialists for practical management during outbreaks, such as COVID-19, applying a consensus development procedure with the Delphi method. With this methodology, we discussed featured endocrine disorders including primary and secondary hyperparathyroidism, pheochromocytoma, adrenocortical carcinoma, Graves' disease and the most frequent FNAC results.

Even though patients with primary hyperparathyroidism (PHPT) are generally diagnosed incidentally as asymptomatic patients, many have symptomatic disease that can affect multiple systems including renal, skeletal and gastrointestinal [9, 10] . Today, surgery remains the gold standard treatment for PHPT. The indications for surgery include all symptomatic patients, and asymptomatic cases with subclinical evidence of increased risk for organ failure [11] .

According to the recent surgical guidelines, parathyroidectomy indications include elevated serum calcium levels (≥ 1 mg/dl above the normal upper limit), osteoporosis (T-score ≤ − 2.5 SD) or evidence of vertebral fractures on diagnostic work-up, decreased eGFR (< 60 ml/min), hypercalciuria (> 400 mg/day), nephrolithiasis or nephrocalcinosis on imaging studies, and age < 50 years [11, 12] . However, when the patients do not meet these indications, have substantial comorbidities or are in a pandemic situation in which elective surgeries cannot be performed, follow-up without an operation can also be an option [10] .

To date, ideal medical treatment for non-operated patients may include hormones (estrogen), bisphosphonates or calcimimetics. However, no single medication can address all targets and replace surgery. Among these medications, cinacalcet (calcimimetic) successfully decreases serum calcium levels and has already been reported as one of the key drugs for treating PHPT, especially for those patients who are not candidates for surgery [13] . In the expert opinion, panelists endorsed dietary changes for the first line of treatment. However, it has also been noted that, for patients with calcium levels above 13 mg/dl or those with hypercalcemic crisis, the best option is surgery due to the increased risk of mortality [14, 15] . In these cases, cinacalcet may also have a significant role as medical treatment [16] .

According to the guidelines, surgery is indicated for patients who are refractory to medical therapy [17, 18] . Moreover, surgical treatment is generally not recommended during a pandemic due to the elevated risk of infection in patients who underwent dialysis [19] . Regarding medical treatment, [20] . Other pharmacological options, such as phosphorus binders, calcium-containing salts or calcium-free binders, such as sevelamer (effective if the phosphorus level is above 4 mg/dl), have limited use as therapy in secondary hyperparathyroidism and their effects on survival are uncertain [21, 22] . Recent clinical trials confirmed the safety and feasibility of cinacalcet as a standard therapy in combination with active vitamin D agents and phosphorus binders [23] . However, it should be noted that, cinacalcet may lead to hypocalcemia and hypercalciuria which may not be suitable for a patient with chronic renal failure. Thus, the right medical algorithm in a pandemic period includes dietary changes, cinacalcet, sevelamer, and dialysis if indicated. The current panel endorsed cinacalcet for the treatment of secondary hyperparathyroidism in the pandemic period.

Medical treatment options for pheochromocytoma include alpha-blockers, a combination of alpha and beta-blockers, beta-blockers, calcium channel blockers and metyrosine. Thus, clinical trials that include randomized, prospective, and controlled studies comparing different pharmacological agents for the treatment of pheochromocytoma are lacking.

In the current study, experts endorsed extended alpha blockage treatment as in a prolonged perioperative period in patients with a pheochromocytoma diagnosis, if effective in controlling clinical symptoms of the disease and in the absence of radiological features of malignancy. However, due to its increased risk of mortality, this potentially lifethreatening disorder can require urgent surgical treatment [24] .

Metastatic or advanced tumors are directly associated with poor prognosis and do not have an effective therapy [25] . Prognosis is mostly related to the stage of the tumor and operability criteria. To date, R0 resection of the tumor with adjuvant Mitotane treatment results with the highest survival pattern [25, 26] . However, there are scant data to support a targeted therapy in patients with advanced ACC beyond ongoing clinical trials and debates regarding the use of chemotherapeutics or radiotherapy for neoadjuvant therapy [27, 28] . Due to the significant value of pathological factors including the stage of the disease and tumor-free resection margins for prognosis, even in a pandemic situation, ACC requires urgent surgical treatment (within 30 days) [29] . As mentioned in the literature, the panelists reject all alternative treatment modalities and endorsed surgery for ACC if the patient is operable [29] .

The treatment modality of Graves' disease (GD) includes anti-thyroid drugs (ATD), radioactive iodine (RAI) treatment or a thyroidectomy [30] . Among these treatments, ATD are indicated as first-line treatments of GD, mostly for temporary management before RAI treatment or surgery [30, 31] .

Panelists endorsed a methimazole and beta-blocker combination for initial therapy during the pandemic and rejected dietary changes and RAI treatment. Only challenging cases including patients with hematological problems, such as neutropenia/pancytopenia, significant comorbidities in which ATDs are contraindicated, refractory cases to medical treatment, rapidly worsening of ophthalmopathy in spite of medical treatment, or asthmatic patients unable to use beta-blockers may require urgent surgery.

Differentiated cancers usually have an excellent prognosis. However, in aggressive subtypes, such as tall cell variants, tumors larger than 4 cm, or those with pathological lymph node involvement or signs of local invasion like nerve palsy, surgery must be considered the first line of treatment even during COVID-19 pandemic [32, 33] .

Regarding papillary microcarcinomas (PMC), most patients are diagnosed with intrathyroidal "low and intermediate risk" cancers with an indolent course and excellent prognosis. The American Thyroid Association (ATA) guidelines also endorsed an active surveillance approach as a low-risk PMC management alternative to immediate surgery [32] . Although the active follow-up approach is being increasingly approved worldwide, the available data on the outcome of active surveillance of PMC are currently only from the East, and additional data should be obtained in several different populations [34] . Of note, in some settings, it could be difficult to ensure adequate follow-up during the acute phase of pandemic, due to restriction of outpatient consultation. In addition, there are also some alternative therapeutic options including radiofrequency ablation (RFA) and percutaneous ethanol injection therapy (PEIT) [35, 36] . However, using these minimally invasive techniques may result in destruction of the final histopathological specimen. Our panelists endorsed the deferral of papillary microcarcinomas in the pandemic period and rejected alternative minimally invasive treatments, such as PEIT or RFA.

Finally, regarding medullary cancer patients, due to its aggressive behavior, current guidelines recommend at least total thyroidectomy and central neck dissection. To prevent a possible extension to the lateral neck lymph nodes, we believe that urgent surgery is the best option. Parallel to this idea, the panelists rejected follow-up of medullary cancers even in a pandemic scenario [37] .

Since there is no evidence for what to do in these clinical situations, all consensus statements were provided for clinical conditions in which surgical treatment was not possible. Expert opinions were gathered to obtain a consensus. Thus, possible limitations of the statement recommendations derived of three topics: the Delphi methodology, the disparity in clinical practice and consensuses, and the composition of the panel.

A group of consecutive questions in two rounds were sent to the experts of the panel to obtain the most factual opinion in a clinically ambiguous situation to shed light on an area with lack of high level of evidence. In practice, the methods are easy to answer and user friendly. On the other hand, low-grade precision of the statements and the difficulty of taking comments into account are some weaknesses Delphi method. The structure of grading with a 9-point Likert scale may be confusing to the panelists [38] . To identify the difference between grade 3 from 5, or 6 from 8 in clinical scenarios may not represent the real world. As the grading system directs the thresholds, some recommendations were rejected due to votes. Twenty-eight of the statements that did not reach enough agreement for recommendation met the rejection threshold at 25%. Therefore, even in this example, rough results of voting can help guide clinicians with patient management in such scenarios.

On the other hand, clinical practice and the statements of the consensus may have disparities. In clinical practice, the management of endocrine disorders is established by evidence-based medicine, but for consensus statements made for outbreak circumstances like COVID-19 the evidence is inconclusive. Although the scenarios depicted in the survey pertain to strict conditions in which surgery is not considered a viable option, a majority of the recommendations surveyed by the panel did not reach a conclusion with a non-surgical option. Therefore, in these scenarios, rough voting results may help clinicians to decide what to do. Although our consensus results outline guidance for daily practice under these pandemic circumstances, the results do not depend on high-level evidence but rather on expert opinion and someway influenced also by local diffusion of the pandemic and different political decisions in different health systems. Therefore, the final decision on how to manage these patients is at the physicians' discretion. It is crucial that practical and rational solutions are found taking multidisciplinary tumor boards into account. Therefore, we believe that these consensus results can help clinicians dealing with endocrine patients under the restrictive and pressing conditions of the COVID-19 pandemic.

The results of this consensus should be regarded only in circumstances in which surgery is not feasible, otherwise it is indicated as standard procedure. Therefore, if it is possible to perform surgical procedures in patients within the clinical scenarios described, surgery should be the mainstay treatment. The consensus results should not be regarded under normal conditions.

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The first draft of the manuscript was written by the authors including Orhan Agcaoglu, Atakan Sezer, Ozer Makay, Murat Faik Erdogan, Fahri Bayram, Sibel Guldiken, Marco Raffaelli, Yusuf Alper Sonmez, Yong-Sang Lee, Kyriakos Vamvakidis, Radu Mihai, Quan-Yang Duh. All authors in the study commented on the manuscript. All authors read and approved the final manuscript.

Orhan Agcaoglu 1 · Atakan Sezer 2 · Ozer Makay 3 · Murat Faik Erdogan 4 · Fahri Bayram 5 · Sibel Guldiken 6 · Marco Raffaelli 7 · Yusuf Alper Sonmez 8 · Yong-Sang Lee 9 · Kyriakos Vamvakidis 10 · Radu Mihai 11 · Quan-Yang Duh 12 · Baris Akinci 13 · Faruk Alagol 14 · Martin Almquist 15 · Marcin Barczynski 16 · Taner Bayraktaroglu 17 · Eren Berber 18 · Yusuf Bukey 19 · Guldeniz Karadeniz Cakmak 20 · Nuh Zafer Canturk 21 · Zeynep Canturk 22 · Mehmet Celik 6 · Ozlem Celik 23 · Banu Ozturk Ceyhan 24 · Sergii Cherenko 25 · Thomas Clerici 26 · David Scott Coombes 27 · Orhan Demircan 28 · Oguzhan Deyneli 14 · Gianlorenzo Dionigi 29 · Ali Ugur Emre 20 · Yesim Erbil 24 · Ali Ilker Filiz 30 · Hulya Ilıksu Gozu 31 · Sibel Ozkan Gurdal 32 · Gunay Gurleyik 33 · Mehmet Haciyanli 34 · Abut Kebudi 30 · Seokmo Kim 9 · Giannis Koutelidakis 35 · Bekir Kuru 36 · Meral Mert 37 · Guzide Gonca Oruk 38 · Serdar Ozbas 24 · Fausto Palazzo 39 · Rumen Pandev 40 · Phillip Riss 41 · Tevfik Sabuncu 42 · Ibrahim Sahin 43 · Gurhan Sakman 44 · Fusun Saygili 45 · Yasemin Giles Senyurek 46 · Ilya Sleptsov 47 · Sam Van Slycke 48 · Serkan Teksoz 19 · Tarik Terzioglu 49 · Serdar Tezelman 1 · Fatih Tunca 46 · Mustafa Umit Ugurlu 50 · Mehmet Uludag 51 · Jesus Villar-del-Moral 52 · Menno Vriens 53 · Dilek Yazici 14 1